Nature Search

Detergent structure in crystals of a bacterial photosynthetic reaction centre

M. Roth
A. Lewit-Bentley
D. Oesterhelt
Research24 Aug 1989
Nature

Volume: 340, P: 659-662
Proterozoic depletion of the lithosphere recorded in mantle xenoliths from Inner Mongolia

F.-L. Deng
J. D. Macdougall
Research26 Nov 1992
Nature

Volume: 360, P: 333-336
Observation of a thin layer of material in the upper stratosphere

L. Thomas
D. P. Wareing
D. B. Jenkins
Research13 Dec 1984
Nature

Volume: 312, P: 627-628
Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

A recent clinical trial shows that a proportion of lung cancer patients carrying the EGFR T790M mutation develop resistance to osimertinib. In this study, the authors show that T790M subclonality is associated with worse clinical outcome likely through co-occurring PIK3CA alterations, which can be targeted by PI3K pathway inhibitors.

Tereza Vaclova
Ursula Grazini
Elza C. de Bruin
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-11
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates

Closed-loop optogenetic stimulation with excitatory opsins enables the precise manipulation of neural dynamics in brain slices from transgenic mice and in anaesthetized non-human primates.

B. Zaaimi
M. Turnbull
A. Jackson
Research20 Oct 2022
Nature Biomedical Engineering

Volume: 7, P: 559-575
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Charnockite geobarometers based on coexisting garnet—pyroxene—plagioclase—quartz

D. Perkins III
R. C. Newton
Research09 Jul 1981
Nature

Volume: 292, P: 144-146
Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

Montserrat Camps
Amanda Carozzi
Peter Gierschik
Research17 Dec 1992
Nature

Volume: 360, P: 684-686
Genetic analysis of ozone-induced acute lung injury in sensitive and resistant strains of mice

Daniel R. Prows
Howard G. Shertzer
George D. Leikauf
Research01 Dec 1997
Nature Genetics

Volume: 17, P: 471-474
Stochastic accretion of the Earth

N-body simulations show that the Earth might have accreted stochastically from various precursor bodies with different compositions depending on their formation temperature. This scenario fits the elemental isotope composition of the bulk Earth and suggests the presence of a radial gradient in the composition of the protoplanetary disk.

Paolo A. Sossi
Ingo L. Stotz
Hugh St. C. O’Neill
Research07 Jul 2022
Nature Astronomy

Volume: 6, P: 951-960
The Hardness of Metals and its Measurement

C. H. D.
Books & Arts14 Sept 1935
Nature

Volume: 136, P: 415
Developing ontologies in decentralised settings

Alexander Garcia
Kieran O’Neill
Frank Gibson
ResearchOpen Access08 May 2009
Nature Precedings

P: 1
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Research25 Mar 2019
Nature Genetics

Volume: 51, P: 659-674
Frequency dependence of elasticity of rock—test of seismic velocity dispersion

B. J. BRENNAN
F. D. STACEY
Research21 Jul 1977
Nature

Volume: 268, P: 220-222
Haemagglutinin of Rubella Virus

T. FURUKAWA
S. PLOTKIN
M. PROFETA
Research08 Jul 1967
Nature

Volume: 215, P: 172-173
NGC3256: an emerging elliptical galaxy

J. R. Graham
G. S. Wright
M. F. Bode
Research19 Jul 1984
Nature

Volume: 310, P: 213-214
A possible neuronal basis for Doppler-shift compensation in echo-locating horseshoe bats

Walter Metzner
Research12 Oct 1989
Nature

Volume: 341, P: 529-532
Association of polyanion resistance with tumorigenicity and other properties in BHK/21 cells

G. D. CLARKE
MOIRA SHEARER
P. J. RYAN
Research06 Dec 1974
Nature

Volume: 252, P: 501-503
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Jun Fang
Jinping Jia
Laufey T. Amundadottir
ResearchOpen Access27 Apr 2017
Nature Communications

Volume: 8, P: 1-17
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 331-341
Mitochondrial complex I activity in microglia sustains neuroinflammation

Blocking mitochondrial complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in vivo in an animal disease model.

L. Peruzzotti-Jametti
C. M. Willis
S. Pluchino
ResearchOpen Access13 Mar 2024
Nature

Volume: 628, P: 195-203
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane region.

Weikang Cai
Masaji Sakaguchi
C. Ronald Kahn
ResearchOpen Access27 Mar 2017
Nature Communications

Volume: 8, P: 1-14
Complex pectin metabolism by gut bacteria reveals novel catalytic functions

The hierarchical deconstruction of the complex pectic glycan rhamnogalacturonan-II by the human gut bacterium Bacteroides thetaiotaomicron reveals seven new families of glycoside hydrolases and three catalytic functions not previously observed.

Didier Ndeh
Artur Rogowski
Harry J. Gilbert
Research22 Mar 2017
Nature

Volume: 544, P: 65-70
Butler enables rapid cloud-based analysis of thousands of human genomes

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Biotechnology

Volume: 38, P: 288-292
A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

Ten years after the discovery of the Higgs boson, the ATLAS experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 52-59
Complement genes contribute sex-biased vulnerability in diverse disorders

Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

Nolan Kamitaki
Aswin Sekar
Steven A. McCarroll
Research11 May 2020
Nature

Volume: 582, P: 577-581
Support for a possible schizophrenia vulnerability locus in region 5q22–31 in Irish families

R E Straub
C J MacLean
K S Kendler
Research01 Mar 1997
Molecular Psychiatry

Volume: 2, P: 148-155
Cosmogony of the asteroidal belt

HANNES ALFVÉN
WING-HUÉN IP
MARTIN D. BURKENROAD
Research23 Aug 1974
Nature

Volume: 250, P: 634-636
Rare variant contribution to human disease in 281,104 UK Biobank exomes

The authors analyse rare protein-coding genetic variants for association with 18,780 traits in the UK Biobank cohort.

Quanli Wang
Ryan S. Dhindsa
Slavé Petrovski
ResearchOpen Access10 Aug 2021
Nature

Volume: 597, P: 527-532
Disentangling oncogenic amplicons in esophageal adenocarcinoma

Esophageal adenocarcinoma is characterised by frequent amplifications in oncogenes. Here, the authors use short- and long-read sequencing approaches to analyze primary tumor samples and tumour-derived organoids and to investigate the mechanisms underlying complex amplifications.

Alvin Wei Tian Ng
Dylan Peter McClurg
Rebecca C. Fitzgerald
ResearchOpen Access14 May 2024
Nature Communications

Volume: 15, P: 1-13
The value of the world's ecosystem services and natural capital

Robert Costanza
Ralph d'Arge
Marjan van den Belt
Research15 May 1997
Nature

Volume: 387, P: 253-260
Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants

Zineb Lakhrif
Agathe Poupée-Beaugé
Isabelle Dimier-Poisson
ResearchOpen Access18 Apr 2025
npj Vaccines

Volume: 10, P: 1-18
Concentration Dependence of Sedimentation Coefficient of Deoxyribonucleic Acid with added Sodium Chloride

PRASANTA K. GANGULI
AMRITA L. BHATTACHARYYA
Research22 Dec 1962
Nature

Volume: 196, P: 1201-1203
Characterization of the human cysteinyl leukotriene CysLT₁ receptor

Kevin R. Lynch
Gary P. O'Neill
Jilly F. Evans
Research24 Jun 1999
Nature

Volume: 399, P: 789-793
Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma

Langenau, Pinello and colleagues identify tumor-propagating stem cells in rhabdomyosarcoma that sustain tumorigenesis through integrated single-cell and functional characterization of patient-derived samples and preclinical models in vivo.

Yun Wei
Qian Qin
David M. Langenau
Research18 Aug 2022
Nature Cancer

Volume: 3, P: 961-975
Author Correction: Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase

Shane M. O’Carroll
Christian G. Peace
Luke A. J. O’Neill
Amendments and Corrections12 Dec 2024
Nature Metabolism

Volume: 7, P: 228
A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer

Cisplatin is the most frequently used chemotherapeutic agent for the treatment of patients with oral cavity squamous cell carcinoma (OCSCC), however, systemic administration is often associated with dose limiting side effects. Here the authors design and test a nano-engineered patch system (PRV111) for the local delivery of cisplatin-loaded chitosan nanoparticles and report the results of a phase 1/2 clinical trial of PRV111 in patients with OCSCC.

Manijeh Goldberg
Aaron Manzi
Evgeny Izumchenko
ResearchOpen Access17 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Wolbachia infection in Aedes aegypti does not affect its vectorial capacity for Dirofilaria immitis

Takahiro Shirozu
Maria Angenica F. Regilme
Shinya Fukumoto
ResearchOpen Access28 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Dynamics of double and single Wolbachia infections in Drosophila simulans from New Caledonia

A C James
M D Dean
J W O Ballard
Research25 Mar 2002
Heredity

Volume: 88, P: 182-189
Extensive standing genetic variation from a small number of founders enables rapid adaptation in Daphnia

Standing genetic variation allows natural populations to evolve rapidly. Genome sequences of a resurrected Daphnia population show that genetic variation carried by only five founding individuals from the regional genotype pool is enough to fuel rapid evolution in response to strong selection pressures with no evidence of genetic erosion.

Anurag Chaturvedi
Jiarui Zhou
Luc De Meester
ResearchOpen Access14 Jul 2021
Nature Communications

Volume: 12, P: 1-9
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

PIEZO1 signalling mediates activation of a proinflammatory response to cyclical pressure fluctuations in immune cells.

Angel G. Solis
Piotr Bielecki
Richard A. Flavell
Research21 Aug 2019
Nature

Volume: 573, P: 69-74
The mutational landscape of human somatic and germline cells

The authors report the mutational landscape of 29 cell types from microdissected biopsies from 19 organs and explore the mechanisms underlying mutation rates in normal tissues.

Luiza Moore
Alex Cagan
Raheleh Rahbari
Research25 Aug 2021
Nature

Volume: 597, P: 381-386
Is this a record?

PHILIP D. GINGERICH
Correspondence07 Jan 1982
Nature

Volume: 295, P: 8
Evolution of genes and genomes on the Drosophila phylogeny

An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

Andrew G. Clark
Michael B. Eisen
Iain MacCallum
Research08 Nov 2007
Nature

Volume: 450, P: 203-218
Adaptation and conservation insights from the koala genome

The assembly of the genome of the koala provides insights into its adaptive biology and identifies gene expansions that contribute to its ability to detoxify eucalyptus-derived compounds and perceive plant secondary metabolites.

Rebecca N. Johnson
Denis O’Meally
Katherine Belov
ResearchOpen Access02 Jul 2018
Nature Genetics

Volume: 50, P: 1102-1111
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in cases versus controls and identify 8 genome-wide significant loci as well as novel suggestive loci conferring either risk or protection to schizophrenia.

Christian R Marshall
Daniel P Howrigan
Jonathan Sebat
Research21 Nov 2016
Nature Genetics

Volume: 49, P: 27-35
Short-term psychological impact of the BRCA1/2 test result in women with breast cancer according to their perceived probability of genetic predisposition to cancer

A Brédart
J L Kop
S Dolbeault
ResearchOpen Access05 Mar 2013
British Journal of Cancer

Volume: 108, P: 1012-1020
The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations

T. Walker
P. H. Johnson
A. A. Hoffmann
Research24 Aug 2011
Nature

Volume: 476, P: 450-453
Accurate whole human genome sequencing using reversible terminator chemistry

David R. Bentley
Shankar Balasubramanian
Anthony J. Smith
ResearchOpen Access06 Nov 2008
Nature

Volume: 456, P: 53-59
Self-organized photosynthetic nanoparticle for cell-free hydrogen production

Photosynthetic nanoparticles obtained from a thermophilic bacterium can produce a stable supply of hydrogen at temperatures up to 55 °C with a yield that is approximately 25 times greater than current hydrogen production strategies.

Ifeyinwa J. Iwuchukwu
Michael Vaughn
Barry D. Bruce
Research08 Nov 2009
Nature Nanotechnology

Volume: 5, P: 73-79

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