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This study demonstrates that the curvature of the cell membrane directly regulates the spatial distribution of Piezo1, a widely expressed mechanosensitive ion channel. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics

Patritumab deruxtecan (HER3-DXd) is a promising therapy for breast cancer, targeting HER3. Here, the authors analyse the genomic factors that affect the response to HER3-DXd in patients with early-stage HER2-negative breast cancer as part of the SOLTI-1805 TOT-HER3 clinical trial and report outcomes for Part B of the trial using lower HER3-DXd dose in patients with HER2-negative breast cancer.

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Data on chemical concentrations in commonly recommended diets are sparse. This study estimates the association between adherence to three dietary patterns considered healthy and exposure to environmental chemicals in a multi-racial pregnancy cohort, underscoring the need for increased regulation and monitoring of environmental contaminants.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

S. aureus biofilms stimulate CXCL10 chemokine secretion, via the biofilm matrix compound PNAG, which also stimulates NF-κB, Dectin-1 and CARD9 expression, inducing monocyte formation, in turn triggering immune response at the site of infection.

Phylogenetic analysis of trait heritability (PATH) applies phylogenetic correlations to single-cell lineage tracing data, quantifying cell state plasticity and transition probabilities. PATH offers insights into cell state heritability and transition dynamics in cancers.

Electron-beam lithography is often used for patterning of asymmetric metal electrodes for nanoscale devices, but suffers from several limitations. Here, the authors report a new adhesion lithography process, which allows for high-throughput and simple fabrication of nanogap metal electrodes.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

QS-21—an FDA-approved vaccine adjuvant—and several structural analogues of QS-21 can be synthesized in engineered yeast strains, and this process is much less laborious compared with the conventional mode of extraction from the Chilean soapbark tree.

Cortical and subcortical activity can be parsimoniously understood as resulting from excitations of fundamental, resonant modes of the brain’s geometry rather than from modes of complex interregional connectivity.

In this prespecified interim analysis of the KEYNOTE-756 phase 3 trial, pembrolizumab and chemotherapy treatment of patients with high-risk, early-stage, estrogen receptor-positive/human epidermal growth factor receptor-negative breast cancer improved the pathological complete response rate compared with chemotherapy alone.

An integrated workflow that uses robotics and machine learning to discover all-natural plastic substitutes with programmable properties is presented.

We create a three-dimensional model of inner core fine-scale heterogeneity, showing that inner core scattering is ubiquitous and that it substantially increases in strength 500–800 km beneath the inner core boundary.

Halogenase enzymes are of interest as halogenating tools for organic synthesis. Here the authors show that the bacterial FAD-dependent phenolic halogenase PltM chlorinates, brominates and iodinates a variety of substrates and reveal the structural basis for its substrate versatility and provide insights into the FAD recycling mechanism of PltM.

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid differentiation.

Fruit senescence is a complex physiological process. Here, the authors construct a single-cell expression atlas of pitaya pericarp pitaya to provide a spatiotemporal perspective of the dynamic process of plant senescence.

CRISPR screen identifies coactivators of the androgen receptor (AR) complex, including NSD2. NSD2 contributes to AR cistrome reprogramming during prostate cancer progression, and its degradation via a novel PROTAC reduces prostate cancer cell viability in vitro.

Plant pathogenic bacteria use host metabolites as virulence cues and nutrients. Here, Rogan et al. show that proline is depleted from the extracellular spaces of immune-elicited Arabidopsis leaves and that this depletion limits the growth of Pseudomonas syringae.

Open-access 3D images of whole cells and tissues with combined finer resolution and larger sample size are enabled by advances in focused ion beam-scanning electron microscopy.

In order to design cancer immune therapies, it is important to understand how tumours evade the immune response that is mounted against them. Authors here analyse the distribution and properties of immune cells in hepatocellular carcinoma and describe a progressive tumour-immune co-evolution programme from early to late stage cancer.

In this prespecified analysis of the ongoing TORCHLIGHT phase 3 trial, first-line treatment with toripalimab and nab-paclitaxel in patients with advanced triple-negative breast cancer led to significantly longer progression-free survival in the PD-L1-positive population compared to nab-paclitaxel alone.

Organism-wide RNA interference (RNAi) is due to the movement of mobile RNA species throughout the organism. New genetic evidence shows that double-stranded RNA (dsRNA), which triggers RNAi, and at least one dsRNA intermediate produced during RNAi can act as or generate mobile silencing RNAs in Caenorhabditis elegans. Interestingly, single-stranded primary and amplified secondary siRNAs do not generate mobile silencing RNAs.

Analyses of the proportions of individuals who have completed key levels of schooling across all low- and middle-income countries from 2000 to 2017 reveal inequalities across countries as well as within populations.

Myelodysplastic syndromes are a broad group of haematopoietic malignancies that often progress to acute myeloid leukaemia. Here, the authors show that linear and branched evolution occurs within myelodysplastic syndrome and these patterns can be impacted by treatment.

TANK-binding kinase-1 (TBK1) and its homologue IκB kinase-ε (IKKε) are critical in the induction of the interferon response and the response to infection by pathogens. Here the authors show that pharmacological targeting of TBK1 AND IKKε reduces the immunopathology seen in a murine model of SARS-COV-2 infection.

Sun et al. identify a stem cell population of CD133⁺ endothelial-like cells (ELCs) that contribute to neovascularization. ELCs become dysfunctional with age, but ELC supplementation or pamidronate treatment to counter ELC aging promotes longevity.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

The Nuclear-physics and Multi-Messenger Astrophysics framework, NMMA, combines multiple information from neutron stars and neutron star mergers. Here, the authors show an update of the NMMA framework to constrain neutron star equation of state by simultaneously analyzing multi-messenger observations.

Transancestral GWAS meta-analysis in 160,420 individuals identifies 139 loci associated with refractive error, including myopia. Newly identified genes implicate pathways involved in eye growth and light signaling cascades.