Nature Search

Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation

Hollunder et al. identify networks where deep brain stimulation reduces symptoms for Parkinson’s disease, Tourette’s syndrome, dystonia and obsessive-compulsive disorder. This revealed a fronto-rostral topography that segregates the frontal cortex.

Barbara Hollunder
Jill L. Ostrem
Andreas Horn

ResearchOpen Access22 Feb 2024

Nature Neuroscience

Volume: 27, P: 573-586

Levodopa influence on turning dynamics in people with Parkinson’s disease

Lakshmi Pillai
Reid D. Landes
Tuhin Virmani

ResearchOpen Access23 Apr 2025

Scientific Reports

Volume: 15, P: 1-13

Evaluation and deployment of a unified MPPT controller for hybrid Luo converter in combined PV and wind energy systems

K. Kumar
V. Lakshmi Devi
Ali ELrashidi

ResearchOpen Access08 Feb 2024

Scientific Reports

Volume: 14, P: 1-15

Odour-imagery ability is linked to food craving, intake, and adiposity change in humans

Perszyk et al. identify the neural basis for odour-imagery ability and show that it indirectly predicts weight-gain susceptibility through a mechanism that is dependent on food-cue reactivity.

Emily E. Perszyk
Xue S. Davis
Dana M. Small

Research28 Aug 2023

Nature Metabolism

Volume: 5, P: 1483-1493

Ethanol and Methanol Metabolites in Alcohol Withdrawal

GASTON MAGRINAT
JOHN P. DOLAN
BERNARD KOROL

Research01 Jul 1973

Nature

Volume: 244, P: 234-235

Time-dependent memory transformation along the hippocampal anterior–posterior axis

Detailed memories are transformed into gist-like memories over time. Here, the authors report that this change is linked to a time-dependent reorganization within the hippocampus, such that anterior activity supporting memory specificity declines over time while posterior activity patterns carrying gist representations remain more stable.

Lisa C. Dandolo
Lars Schwabe

ResearchOpen Access23 Mar 2018

Nature Communications

Volume: 9, P: 1-11

Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data

A machine learning approach is presented to identify dominant patterns in disease progression in amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and Parkinson’s disease. The nonlinearity of ALS progression has important clinical implications.

Divya Ramamoorthy
Kristen Severson
Ernest Fraenkel

ResearchOpen Access08 Sept 2022

Nature Computational Science

Volume: 2, P: 605-616

LUX ARRHYTHMO mediates crosstalk between the circadian clock and defense in Arabidopsis

Circadian control of plant defence likely reflects plants’ ability to coordinate development and defense. Here, Zhang et al. show that LUX regulates stomatal defense and SA/JA signaling, leading to broad-spectrum disease resistance, and that JA signaling can, in turn, regulate clock activity.

Chong Zhang
Min Gao
Hua Lu

ResearchOpen Access11 Jun 2019

Nature Communications

Volume: 10, P: 1-14

Internal control beliefs shape positive affect and associated neural dynamics during outcome valuation

Human affect is shaped in part by whether desirable states are achieved under personal control. Here, the authors show that control beliefs affect happiness and pride, and how those effects relate to neural responses in the prefrontal cortex and behavioral preferences for exerting control.

David S. Stolz
Laura Müller-Pinzler
Frieder M. Paulus

ResearchOpen Access06 Mar 2020

Nature Communications

Volume: 11, P: 1-13

Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex

Here the authors record the responses evoked in the hand and arm representations of M1 during intracortical microstimulation in the hand representation of S1, and show somatotopically organized connections with motor cortex. The resulting interference with motor decoding is task dependent but can be alleviated by using biomimetic stimulation.

Natalya D. Shelchkova
John E. Downey
Sliman J. Bensmaia

ResearchOpen Access10 Nov 2023

Nature Communications

Volume: 14, P: 1-11

Individual variability in brain representations of pain

Pain experience is highly individual, but its individual-specific brain features remain unclear. The authors identify brain regions with consistent versus variable representations of pain across a large sample of individuals.

Lada Kohoutová
Lauren Y. Atlas
Choong-Wan Woo

Research30 May 2022

Nature Neuroscience

Volume: 25, P: 749-759

Quantifying the impact of workshops promoting microbiome data standards and data stewardship

Julia M. Kelliher
Francisca E. Rodriguez
Emiley A. Eloe-Fadrosh

ResearchOpen Access22 Mar 2025

Scientific Reports

Volume: 15, P: 1-10

2-Trifluoromethylbenzimidazoles: A New Class of Herbicidal Compounds

D. E. BURTON
A. J. LAMBIE
D. T. SAGGERS

Research18 Dec 1965

Nature

Volume: 208, P: 1166-1169

Data-driven EV charging infrastructure with uncertainty based on a spatial–temporal flow-driven (STFD) models considering batteries

Talal Alharbi
Ahmed Abdalrahman
Mostafa H. Mostafa

ResearchOpen Access25 Jul 2025

Scientific Reports

Volume: 15, P: 1-21

Impact of truck electrification on air pollution disparities in the United States

Grid decarbonization and truck electrification investments in the United States aim to support a just energy transition. Although such efforts reduce air-pollution-related premature mortality in disadvantaged communities, the relative disparity between disadvantaged and non-disadvantaged communities increases.

Wilson H. McNeil
Jason Porzio
Corinne D. Scown

ResearchOpen Access11 Feb 2025

Nature Sustainability

Volume: 8, P: 276-286

Vulnerability of US thermoelectric power generation to climate change when incorporating state-level environmental regulations

Climate change will affect future water availability and temperature and hence thermoelectric power generation, which uses water for cooling. This study explores future usable capacity for existing thermoelectric power under different scenarios, including US state-level environmental regulations.

Lu Liu
Mohamad Hejazi
Xiao Zhang

Research10 Jul 2017

Nature Energy

Volume: 2, P: 1-5

A New Systemic Rust Therapeutant

E. EVANS
D. T. SAGGERS

Research11 Aug 1962

Nature

Volume: 195, P: 619-620

Enhancing sparse data recommendations with self-inspected adaptive SMOTE and hybrid neural networks

Ramesh Vatambeti
Hari Prasad Gandikota
Koteswararao Ch

ResearchOpen Access18 May 2025

Scientific Reports

Volume: 15, P: 1-16

Identification of QTLs conferring resistance to downy mildew in legacy cultivars of lettuce

Ivan Simko
Amy J. Atallah
Richard W. Michelmore

ResearchOpen Access07 Oct 2013

Scientific Reports

Volume: 3, P: 1-10

Uncovering heterogeneous interactions in online commercial networks

Fangfeng Zhang
An Zeng
Zengru Di

ResearchOpen Access08 Dec 2017

Scientific Reports

Volume: 7, P: 1-10

Nutritive Value of Proteins

D. P. CUTHBERTSON

Research18 Jan 1958

Nature

Volume: 181, P: 151-154

Transfer of Stratospheric Fission Products into the Troposphere

D. H. PEIRSON

Research11 Nov 1961

Nature

Volume: 192, P: 497-500

Acute isolation is associated with increased reward seeking and reward learning in human adolescents

This study shows that, following social isolation, adolescents show increased sensitivity to rewards during effort-based decision making and reward learning. Access to virtual social interactions during isolation partially remediates these effects.

Livia Tomova
Emily Towner
Sarah-Jayne Blakemore

ResearchOpen Access05 Sept 2025

Communications Psychology

Volume: 3, P: 1-16

A diverse proteome is present and enzymatically active in metabolite extracts

Metabolite extraction with organic solvents is assumed to remove/denature proteins. Here, the authors uncover a vast landscape of >1,000 proteins in metabolite extracts. These proteins can retain catalytic activity and drive post-extraction metabolite changes, obscuring biological interpretation.

Rachel (Rae) J. House
Molly T. Soper-Hopper
Ryan D. Sheldon

ResearchOpen Access10 Jul 2024

Nature Communications

Volume: 15, P: 1-17

Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls

The neurochemical basis of compulsive behaviour is not well understood. Here, the authors show that levels of glutamate and GABA in the supplementary motor area and anterior cingulate cortex relate to compulsive behaviour in healthy controls and individuals with OCD.

Marjan Biria
Paula Banca
Trevor W. Robbins

ResearchOpen Access27 Jun 2023

Nature Communications

Volume: 14, P: 1-13

How people wake up is associated with previous night’s sleep together with physical activity and food intake

In a prospective longitudinal study of 833 adults, we demonstrate that how you wake up and regain alertness in the hours after sleep is weakly associated with your genes. Instead, the modifiable factors of how you are sleeping, eating and exercising influence your return to full alertness, free of sleepiness.

Raphael Vallat
Sarah E. Berry
Matthew P. Walker

ResearchOpen Access19 Nov 2022

Nature Communications

Volume: 13, P: 1-15

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

In glioblastoma (GBM), tumour microtubes (TM) connect tumour cells to a broader cellular network, with roles in tumour progression and therapy resistance. Here, the authors combine a dye uptake method in GBM xenograft models with subsequent scRNA-seq to infer a TM connectivity signature, finding CHI3L1 as a marker of connectivity.

Ling Hai
Dirk C. Hoffmann
Tobias Kessler

ResearchOpen Access06 Feb 2024

Nature Communications

Volume: 15, P: 1-29

Machine learning-based approach for reduction of energy consumption in hybrid energy storage electric vehicle

T. Paulraj
Yeddula Pedda Obulesu

ResearchOpen Access11 Aug 2025

Scientific Reports

Volume: 15, P: 1-31

Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement

The management of patients with pheochromocytoma and paraganglioma associated with pathogenic variants in SDHB can be challenging. This Consensus statement aims to provide a guide for the clinical decision-making process in these patients.

David Taïeb
Svenja Nölting
Karel Pacak

Reviews14 Dec 2023

Nature Reviews Endocrinology

Volume: 20, P: 168-184

Empathic neural responses are modulated by the perceived fairness of others

Tania Singer
Ben Seymour
Chris D. Frith

Research18 Jan 2006

Nature

Volume: 439, P: 466-469

State-dependent responses to intracranial brain stimulation in a patient with depression

Acute mapping of responses to focal electrical neuromodulation in a patient with treatment-resistant depression reveals distinct mood and symptom changes that are highly context dependent.

Katherine W. Scangos
Ghassan S. Makhoul
Andrew D. Krystal

Research18 Jan 2021

Nature Medicine

Volume: 27, P: 229-231

Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical diagnosis to show that tissue volume changes appear earlier in the basal forebrain than in the entorhinal cortex.

Taylor W. Schmitz
R. Nathan Spreng
Ansgar J. Furst

ResearchOpen Access04 Nov 2016

Nature Communications

Volume: 7, P: 1-13

Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial

In the phase 2 PASSPORT study, treatment with the anti-tau antibody gosuranemab did not show clinical benefit in participants with supranuclear palsy, suggesting that N-terminal tau neutralization does not translate into clinical efficacy.

Tien Dam
Adam L. Boxer
Samantha Budd Haeberlein

Research12 Aug 2021

Nature Medicine

Volume: 27, P: 1451-1457

Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice

Bacterial and host fucosylation protect against colitis by maintaining the IgA B cell response in the mouse gut.

Chao Lei
Chao Luo
Zhongbin Deng

Research17 Dec 2024

Nature Microbiology

Volume: 10, P: 126-143

H₂S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Nitric oxide (NO) and hydrogen sulphide (H₂S) are two gaseous signalling molecules produced in tissues. Here the authors propose that NO and H₂S react with each other to form nitroxyl (HNO), which activates the TRPA1 channel in nerve cells and triggers the release of the vasoactive peptide CGRP.

Mirjam Eberhardt
Maria Dux
Milos R. Filipovic

ResearchOpen Access15 Jul 2014

Nature Communications

Volume: 5, P: 1-17

Effect of a Very Bright Flash on Cone Vision and Cone Pigments in Man

W. A. H. RUSHTON
H. D. BAKER

Research02 Nov 1963

Nature

Volume: 200, P: 421-423

Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial

An open-label clinical trial of an oral absorbent that sequesters phenolic molecules in the gut shows safety and tolerability in adolescents with autism, reduces levels of gut-derived metabolites in circulation and reduces anxiety and irritability.

A. Stewart Campbell
Brittany D. Needham
Sarkis K. Mazmanian

Research14 Feb 2022

Nature Medicine

Volume: 28, P: 528-534

Human-made news vs AI-generated news: a comparison of Portuguese and Spanish journalism students’ evaluations

João Pedro Baptista
Rubén Rivas-de-Roca
Concha Pérez-Curiel

ResearchOpen Access24 Apr 2025

Humanities and Social Sciences Communications

Volume: 12, P: 1-9

Grid-enhancing technologies for clean energy systems

Grid-enhancing technologies increase the capacity and stability of power transmission networks without requiring major upgrades and investment. This Review describes the use of grid-enhancing technologies to maximize power transmission and enable renewable energy integration into existing grids.

Tong Su
Junbo Zhao
Jake P. Gentle

Reviews15 Jan 2025

Nature Reviews Clean Technology

Volume: 1, P: 16-31

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease

A spinal cord neuroprosthesis targeting leg motor neurons in real time improves walking and reduces freezing of gait in non-human primate models and in one individual with advanced Parkinson’s disease.

Tomislav Milekovic
Eduardo Martin Moraud
G. Courtine

Research06 Nov 2023

Nature Medicine

Volume: 29, P: 2854-2865

CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease

This study characterizes the CSF proteome changes underlying Dementia with Lewy Bodies (DLB) and identifies pathophysiological and diagnostic leads associated to this cause of dementia. Findings have been translated into a biomarker panel that could identify DLB patients with high accuracy across different cohorts.

Marta del Campo
Lisa Vermunt
Charlotte E. Teunissen

ResearchOpen Access13 Sept 2023

Nature Communications

Volume: 14, P: 1-14

Selective KOR antagonist alters functional patch sizes in individualized brain system: results from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)

Hoki Fung
Ruby M. Potash
Matthew D. Sacchet

Research13 May 2025

Neuropsychopharmacology

Volume: 50, P: 1430-1438

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis

A comprehensive longitudinal analysis of individuals with preclinical Huntington’s disease identifies biomarkers of neurodegeneration and somatic expansion in blood DNA, detectable years before symptom onset.

Rachael I. Scahill
Mena Farag
Sarah J. Tabrizi

ResearchOpen Access17 Jan 2025

Nature Medicine

Volume: 31, P: 807-818

Optimized placement and sizing of solar photovoltaic distributed generation using jellyfish search algorithm for enhanced power system performance

P Rajakumar
P. M. Balasubramaniam
P. Aravind

ResearchOpen Access01 Jul 2025

Scientific Reports

Volume: 15, P: 1-27

Neuroanatomical basis for first- and second-order representations of bodily states

H. D. Critchley
C. J. Mathias
R. J. Dolan

Research01 Feb 2001

Nature Neuroscience

Volume: 4, P: 207-212

Assessment of pain symptoms and quality of life using the International Spinal Cord Injury Data Sets in persons with chronic spinal cord injury

Katie Gibbs
Andrew Beaufort
Ona Bloom

ResearchOpen Access15 Apr 2019

Spinal Cord Series and Cases

Volume: 5, P: 1-9

Functional recovery in parkinsonian monkeys treated with GDNF

Don M. Gash
Zhiming Zhang
Greg A. Gerhard

Research21 Mar 1996

Nature

Volume: 380, P: 252-255

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

Cross-sectional and longitudinal PET imaging of amyloid beta and tau in the human brain is combined with gene expression profiles to define the interactions between Alzheimer’s disease-related pathology propagation and brain-region-specific vulnerability.

Jorge Sepulcre
Michel J. Grothe
Keith A. Johnson

Research29 Oct 2018

Nature Medicine

Volume: 24, P: 1910-1918

Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these diseases.

Heike Stein
Joao Barbosa
Albert Compte

ResearchOpen Access25 Aug 2020

Nature Communications

Volume: 11, P: 1-11

A synthesis of evidence for policy from behavioural science during COVID-19

Evaluation of evidence generated to test 19 proposed policy recommendations and guidance for the future.

Kai Ruggeri
Friederike Stock
Robb Willer

ResearchOpen Access13 Dec 2023

Nature

Volume: 625, P: 134-147

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