Tobias Ackermann et al. show that the C/EBPβ Liver-enriched inhibitory protein (LIP) induces aerobic glycolysis and mitochondrial respiration by suppressing the let-7 microRNA family that targets the Lin28b-mRNA. This study identifies LIP as a regulator of metabolic reprogramming that is reminiscent of cancer metabolism.
- Tobias Ackermann
- Götz Hartleben
- Cornelis F. Calkhoven