Heartburn is a challenging clinical symptom to treat as it does not always readily respond to antisecretory therapy. The authors of this Review provide an update on the evidence available to support the mechanisms currently postulated to underlie heartburn: acid reflux, weakly acidic reflux, bile reflux, mechanical stimulation of the esophagus, esophageal hyperalgesia and psychological comorbidity.
- Daphne Ang
- Daniel Sifrim
- Jan Tack
