Nature Search

Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures

Comparative epigenomics has revealed principles underlying the evolution of gene expression regulation, and the integration of epigenomic data is important for a deeper understanding of this evolution. Here the authors report the evolutionary dynamics of the epigenomic regulatory landscape in primates and their impact in recent human evolution.

Raquel García-Pérez
Paula Esteller-Cucala
Tomàs Marquès-Bonet
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-17
Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

U. Benjamin Kaupp
Tetsuhiro Niidome
Shosaku Numa
Research14 Dec 1989
Nature

Volume: 342, P: 762-766
Comparative chromosome painting discloses homologous segments in distantly related mammals

Harry Scherthan
Thomas Cremer
Lutz Frönicke
Research01 Apr 1994
Nature Genetics

Volume: 6, P: 342-347
Sphingosine 1-phosphate and cancer

There is increasing evidence that sphingosine 1-phosphate (S1P), S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase are involved in cancer development and progression. This Review summarizes current research findings and discusses the potential for new therapeutics.

Nigel J. Pyne
Susan Pyne
Reviews17 Jun 2010
Nature Reviews Cancer

Volume: 10, P: 489-503
Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes

Stefano De Renzis
Birte Sönnichsen
Marino Zerial
Research14 Jan 2002
Nature Cell Biology

Volume: 4, P: 124-133
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes

Structural variations (SV) contribute to inter-individual variability. Here, the authors describe a first-generation multi-ancestry Asian SV catalogue containing 73,035 SVs from 8392 Singaporeans to provide insights into Asian SV diversity.

Joanna Hui Juan Tan
Zhihui Li
Nicolas Bertin
ResearchOpen Access04 Nov 2024
Nature Communications

Volume: 15, P: 1-15
The DNA sequence of the human X chromosome

Mark T. Ross
Darren V. Grafham
David R. Bentley
Research17 Mar 2005
Nature

Volume: 434, P: 325-337
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

Julian Borrow
Vincent P. Stanton Jr
David E. Housman
Research01 Sept 1996
Nature Genetics

Volume: 14, P: 33-41
Mapping and analysis of chromatin state dynamics in nine human cell types

Jason Ernst
Pouya Kheradpour
Bradley E. Bernstein
Research23 Mar 2011
Nature

Volume: 473, P: 43-49
Inhibition of retroviral protease activity by an aspartyl proteinase inhibitor

Iyoko Katoh
Teruo Yasunaga
Yoshiyuki Yoshinaka
Research21 Oct 1987
Nature

Volume: 329, P: 654-656
An international two–stage genome–wide search for schizophrenia susceptibility genes

H.W. Moises
L. Yang
T. Helgason
Research01 Nov 1995
Nature Genetics

Volume: 11, P: 321-324
A channel-like transporter for NH₄⁺ on the symbiotic interface of N₂-fixing plants

Stephen D. Tyerman
Lynne F. Whitehead
David A. Day
Research07 Dec 1995
Nature

Volume: 378, P: 629-632
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

In order to design cancer immune therapies, it is important to understand how tumours evade the immune response that is mounted against them. Authors here analyse the distribution and properties of immune cells in hepatocellular carcinoma and describe a progressive tumour-immune co-evolution programme from early to late stage cancer.

Phuong H. D. Nguyen
Martin Wasser
Valerie Chew
ResearchOpen Access17 Mar 2022
Nature Communications

Volume: 13, P: 1-13
Haemophilia B caused by a point mutation in a donor splice junction of the human factor IX gene

D. J. G. Rees
C. R. Rizza
G. G. Brownlee
Research01 Aug 1985
Nature

Volume: 316, P: 643-645
Translocation of vesicles from squid axoplasm on flagellar microtubules

Susan P. Gilbert
Robert D. Allen
Roger D. Sloboda
Research01 May 1985
Nature

Volume: 315, P: 245-248
Delayed recombination as a major source of the soft X-ray background

D. Breitschwerdt
T. Schmutzler
Research27 Oct 1994
Nature

Volume: 371, P: 774-777
Analysis of clinically relevant variants from ancestrally diverse Asian genomes

Clinically significant genetic variation in Asian populations is under-characterized. Here, the authors show the diversity in prevalence and spectrum of human disease and pharmacogenetic variants in a multi-ethnic Asian population.

Sock Hoai Chan
Yasmin Bylstra
Weng Khong Lim
ResearchOpen Access05 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Evaluation of the US COVID-19 Scenario Modeling Hub for informing pandemic response under uncertainty

The US COVID-19 Scenario Modeling Hub produced medium to long term projections based on different epidemic scenarios. In this study, the authors evaluate 14 rounds of projections by comparing them to the epidemic trajectories that occurred, and discuss lessons learned for future similar projects.

Emily Howerton
Lucie Contamin
Justin Lessler
ResearchOpen Access20 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Morphogenesis of a tiered principal retina and the evolution of jumping spiders

A. D. Blest
Margrit Carter
Research09 Jul 1987
Nature

Volume: 328, P: 152-155
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

Micheline Strand
Tomas A. Prolla
Thomas D. Petes
Research16 Sept 1993
Nature

Volume: 365, P: 274-276
Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants

Michael J. Francis
Gillian Z. Hastings
David J. Rowlands
Research18 Nov 1987
Nature

Volume: 330, P: 168-170
The human met oncogene is related to the tyrosine kinase oncogenes

Michael Dean
Morag Park
George F. Vande Woude
Research28 Nov 1985
Nature

Volume: 318, P: 385-388
A large increase in enzyme–substrate affinity by protein engineering

Anthony J. Wilkinson
Alan R. Fersht
Greg Winter
Research12 Jan 1984
Nature

Volume: 307, P: 187-188
F_v fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase

Christian Ostermeier
So Iwata
Hartmut Michel
Research01 Oct 1995
Nature Structural Biology

Volume: 2, P: 842-846
Complete mutagenesis of the HIV-1 protease

Daniel D. Loeb
Ronald Swanstrom
Clyde A. Hutchison III
Research03 Aug 1989
Nature

Volume: 340, P: 397-400
Nickel-copper-cobalt mixed oxide electrode material for high performance asymmetric supercapacitor

M. Manikandan
E. Manikandan
V. Kiruthika
ResearchOpen Access11 May 2024
Scientific Reports

Volume: 14, P: 1-10
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties

S. B. CARTER
T. J. FRANKLIN
W. B. TURNER
Research23 Aug 1969
Nature

Volume: 223, P: 848-850
EGF receptor-associated DNA-nicking activity is due to a M_r-100,000 dissociable protein

Mitali Basu
Kevin Frick
Manjusri Das
Research01 Aug 1985
Nature

Volume: 316, P: 640-641
Similarity of the Cin1 repetitive family of Zea mays to eukaryotic transposable elements

Nancy S. Shepherd
Zsuzsanna Schwarz-Sommer
Heinz Saedler
Research12 Jan 1984
Nature

Volume: 307, P: 185-187
A framework for sharing of clinical and genetic data for precision medicine applications

A secure framework that harmonizes storage and querying of clinical and genetic data using blockchain technology was developed to support combined genotype–phenotype queries, improving transparency into how and when health information is used.

Ahmed Elhussein
Ulugbek Baymuradov
Gamze Gürsoy
ResearchOpen Access03 Sept 2024
Nature Medicine

Volume: 30, P: 3578-3589
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

Anne Simonsen
Roger Lippe
Harald Stenmark
Research30 Jul 1998
Nature

Volume: 394, P: 494-498
Identification of constrained sequence elements across 239 primate genomes

Whole-genome alignment of 239 primate species reveals noncoding regulatory elements that are under selective constraint in primates but not in other placental mammals, that are enriched for variants that affect human gene expression and complex traits in diseases.

Lukas F. K. Kuderna
Jacob C. Ulirsch
Kyle Kai-How Farh
ResearchOpen Access29 Nov 2023
Nature

Volume: 625, P: 735-742
Homozygous mutation Arg₇₆₈Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a Caucasian patient

Verena Materna
Hermann Lage
Research27 Aug 2003
Journal of Human Genetics

Volume: 48, P: 484-486
Human chromosome 11 DNA sequence and analysis including novel gene identification

Todd D. Taylor
Hideki Noguchi
Yoshiyuki Sakaki
Research23 Mar 2006
Nature

Volume: 440, P: 497-500
Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with tumour evolution and a poor prognosis.

Phuong H. D. Nguyen
Siming Ma
Valerie Chew
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Genomic landscape of lung adenocarcinoma in East Asians

Genomic and transcriptomic analysis of lung adenocarcinoma (LUAD) in Asia indicates that Asian LUADs have fewer mutations, lower driver prevalence and fewer copy number alterations than European LUADs.

Jianbin Chen
Hechuan Yang
Weiwei Zhai
Research03 Feb 2020
Nature Genetics

Volume: 52, P: 177-186
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.

Peter H. Dixon
Adam P. Levine
Catherine Williamson
ResearchOpen Access17 Aug 2022
Nature Communications

Volume: 13, P: 1-18
DNA sequence and analysis of human chromosome 18

Chad Nusbaum
Michael C. Zody
Eric S. Lander
Research22 Sept 2005
Nature

Volume: 437, P: 551-555
Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae

Gertrude Koch
Kazuma Tanaka
Yoshimi Takai
Research24 Jul 1997
Oncogene

Volume: 15, P: 417-422
Expression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells

M D Hofer
A Menke
K Giehl
ResearchOpen Access20 Jan 2004
British Journal of Cancer

Volume: 90, P: 455-462
A prospective study of peri-diagnostic and surgical wait times for patients with presumptive colorectal, lung, or prostate cancer

E Grunfeld
J M Watters
W K Evans
ResearchOpen Access16 Dec 2008
British Journal of Cancer

Volume: 100, P: 56-62
Immunoreactive arginine-vasopressin in Brattleboro rat ovary

A. T. W. Lim
S. J. Lolait
J. W. Funder
Research05 Jul 1984
Nature

Volume: 310, P: 61-64
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.

Hyun Ji Noh
Ruqi Tang
Kerstin Lindblad-Toh
ResearchOpen Access17 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Expression of p53 gene in hepatocellular carcinomas induced by aflatoxin B1 with or without human hepatitis B virus in tree shrews

Jianjia Su
Guozhong Qin
Prabhakar D Lotlikar
ResearchOpen Access01 Sept 1997
Experimental & Molecular Medicine

Volume: 29, P: 177-182
Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis

The molecular mechanisms underlying lymph-node metastasis in head and neck squamous-cell carcinoma remain to be investigated. Here, the authors perform single-cell RNA sequencing of cancer cells and CD8 + T cells and suggest potential mechanisms of immune evasion during early metastasis.

Hong Sheng Quah
Elaine Yiqun Cao
N. Gopalakrishna Iyer
ResearchOpen Access27 Mar 2023
Nature Communications

Volume: 14, P: 1-19
Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization

The polarisome is a dynamic protein complex that nucleates F-actin for polarized yeast growth, but its regulation is unclear. Here, the authors report that the polarisome protein Aip5 undergoes Spa2-mediated phase separation in physiological and stress conditions, potentially for regulating actin assembly.

Ying Xie
Jialin Sun
Yansong Miao
ResearchOpen Access07 Nov 2019
Nature Communications

Volume: 10, P: 1-18
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
Identification of new susceptibility loci for IgA nephropathy in Han Chinese

IgA nephropathy is a major cause of end-stage renal disease in China, occurring at a high frequency in Asian populations. Here Li and colleagues conduct a four-stage genome-wide association study in a Chinese population, identifying novel loci and variants associated with disease risk.

Ming Li
Jia-Nee Foo
Jian-Jun Liu
ResearchOpen Access01 Jun 2015
Nature Communications

Volume: 6, P: 1-9

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