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From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

Seasonal metabolomics revealed that taurine increases during low malaria transmission and is linked to asymptomatic Plasmodium falciparum infection.

In a randomized, double-blind, placebo-controlled trial comparing autologous mRNA-engineered BCMA-targeting CAR T cell therapy versus placebo in patients with generalized myasthenia gravis, a significantly higher percentage of patients exhibited a reduction in disease activity in the treatment arm than in the placebo arm.

This study finds that native tree extinctions and alien naturalizations are pushing forests towards fast-growing, resource-demanding species. This global shift could affect carbon storage and ecosystem stability, highlighting the need to protect slow-growing trees.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Researchers have developed a fullerene-decorated PdCo nano-resistor network sensor that achieves fast hydrogen detection time of 0.40 seconds at 0.1% H₂ and a detection limit of 40 ppb at room temperature.

Nitrate contamination in water poses environmental and health risks. Here, authors design alkylated polyaniline polymers that selectively capture nitrate over chloride, improving removal efficiency and reducing costs in wastewater treatment.

Plasma cells (PC) contribute to the pathogenesis of autoimmune diseases by secreting autoantibodies. Strategies to target pathogenic PCs are thus required. Here, the authors profile different PC subsets in naïve and lupus-prone mice and report the emergence and expansion of a CD19^– PC subset in diseased mice that could compromise the effectiveness of CD19-targeting therapies.

Silicon solar cells with hybrid interdigitated back contacts have a power conversion efficiency approaching 95% of the theoretical limit and a fill factor approaching 98% of the theoretical limit.

Approaches making virtual and experimental screening more resource-efficient are vital for identifying effective inhibitors from a vast pool of potential drugs but remain elusive. Here, the authors address this issue by developing an active learning framework leveraging high-throughput molecular dynamics simulations to identify potential inhibitors for therapeutic applications.

Designing reliable and sensitive mechanical sensing technologies based on piezoresistive effect remains a challenge. Here, the authors propose an opto-electro-mechanical coupling strategy to enable giant piezoresistive effect in a highly doped 3C-SiC/Si heterojunction achieving a high GF of 58,000.

Using a photoluminescence-based carrier multiplication mechanism recently proposed for closely spaced silicon nanocrystals in SiO₂, scientists demonstrate that adjacent nanocrystals are excited directly upon absorption of a single high-energy photon. They also demonstrate efficient carrier multiplication with an onset close to the energy conservation threshold of twice the bandgap energy.

Malaria infection risk is complex to quantify, partly because polyclonal as well as asymptomatic infections are common. Here, the authors use parasite genotyping data from a prospective cohort study in Mali to estimate infection incidence at the strain level and explore risk factors associated with heterogeneous infection rates.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Eddy-covariance observations suggest that rain pulses over global drylands drive substantial soil carbon emissions, which are underestimated in current measurement and modelling approaches.

Understanding active-site geometry and structural evolution during electrocatalysis is important for further development. Here the authors use operando X-ray absorption spectroscopy combined with electrochemical impedance spectroscopy to investigate single atom catalysts derived from Vitamin B12.

Codon 158 gain-of-function mutant p53 (158-mutp53) promotes tumourigenesis in lung cancer. Here, the authors show that 158-mutp53 render cancers sensitive to cisplatin and p53 acetylation agents through a mechanism where acetylated mutant p53 upregulates TRAIP and inhibits NF-ĸB signaling.

The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancers.

The bacterium Helicobacter pylori, often found in the human stomach, can be classified into distinct subpopulations associated with the geographic origin of the host. Here, the authors provide insights into H. pylori population structure by collecting over 1,000 clinical strains from 50 countries and generating and analyzing high-quality bacterial genome sequences.

Myotonic dystrophy type 1 (DM1) is caused by defects in the alternative splicing of pre-mRNA. Childs-Disney and colleagues report two small molecules that either induce or reverse DM1-associated splicing defects by modulating the binding of pre-mRNA to muscleblind-like 1 protein.

We fabricated silicon heterojunction back-contact solar cells using laser patterning, producing cells that exceeded 27% power-conversion efficiency.

Monolithic 3D integration of electronics based on fully 2D materials is demonstrated in the performance of artificial intelligence tasks.

The management of charge carrier recombination and transport in heterojunction back contact solar cells poses significant challenges in achieving a high efficiency. Here, authors analyze various loss mechanisms of devices fabricated by laser patterning, and achieve a certified efficiency of 27.09%.

The combination of dynamic, energy driven folding and growth with structural stiffness and length control is difficult to achieve in synthetic polymer self-assembly. Here the authors show that highly charged, monodisperse DNA oligomers assemble via seeded growth into length-controlled supramolecular fibers during heating.

Some intracellular pathogens can directly invade neighboring host cells in cell culture, but it is unclear how this happens in vivo. Here, Tran et al. describe an intracellular bacterium that forms filaments to spread between intestinal epithelial cells in its host nematode, in a process regulated by a conserved nutrient-sensing pathway.

Chen et al. report that the immune modulatory metabolite itaconic acid selectively inhibits the activity of TET DNA dioxygenases to repress the inflammatory responses.

Morphometric analyses of hominid teeth from Early to Middle Pleistocene Java reveal that Meganthropus was a Pleistocene Indonesian hominid distinct from Pongo, Gigantopithecus and Homo, and that molars previously assigned to Homo erectus are more likely to belong to Meganthropus.