Nature Search

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol

Lipid nanoparticles (LNPs) fate after up take by cells is important for therapies. Here, the authors report on key barriers limiting RNA delivery by LNPs, including restricted endosomal escape, ESCRT-mediated membrane repair, and separation of lipid and RNA components during endosomal sorting.

Johanna M. Johansson
Hampus Du Rietz
Anders Wittrup
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Alterations in the Urinary Excretion of Pseudouridine and Deoxycytidine in Rats induced by Glucocorticoids

A. JAKUBOVIČ
Z. ČEKAN
D. DRAHOVSKÝ
Research07 Jan 1967
Nature

Volume: 213, P: 99
Two structural configurations of the skeletal muscle calcium release channel

Elena V. Orlova
Irina I. Serysheva
Wah Chiu
Research01 Jun 1996
Nature Structural Biology

Volume: 3, P: 547-552
Rapid transfer of oxygen to the deep ocean mediated by bubbles

Bubble-mediated flux of oxygen into the Labrador Sea surface ocean contributes to air–sea gas exchange, suggest observations from moored profiling and Argo float data. Climate models that omit the process may underestimate oxygen in the deep ocean.

D. Atamanchuk
J. Koelling
D. W. R. Wallace
Research03 Feb 2020
Nature Geoscience

Volume: 13, P: 232-237
Preparation of Solid Solutions of Free Radicals at Room Temperature

D. BIJL
A. C. ROSE-INNES
Research08 Jan 1955
Nature

Volume: 175, P: 82-83
Defining the role of common variation in the genomic and biological architecture of adult human height

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Andrew R Wood
Tonu Esko
Timothy M Frayling
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1173-1186
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank

Bone marrow adipose tissue accounts for over 10% of human fat mass. Here, Xu et al. use deep learning to measure marrow adiposity in over 45,000 people, and identify genes associated with altered bone marrow adiposity.

Wei Xu
Ines Mesa-Eguiagaray
William P. Cawthorn
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-19
Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation

Aberrant redox homeostasis links lipid metabolism and cell death programs. Here, authors reveal how cell stress reduces growth factor signaling, enriching polyunsaturated fatty acids in phospholipids and sensitizing membranes to oxidative damage.

André Gollowitzer
Helmut Pein
Andreas Koeberle
ResearchOpen Access25 Feb 2025
Nature Communications

Volume: 16, P: 1-31
Crossed Amorphous and Crystalline Chain Orientation in Polythene Film

D. R. HOLMES
R. G. MILLER
C. W. BUNN
Research20 Jun 1953
Nature

Volume: 171, P: 1104-1106
Effect of Additions of Sodium and Potassium and of Peritoneal Dialysis with a Hypotonic Solution of Sodium Chloride on the Sodium and Potassium Contents of the Maternal and Fœtal Serum and the Amniotic Fluid of Rats

H. WINKLER
S. THEIL
E. GOETZE
Research26 May 1962
Nature

Volume: 194, P: 779-780
Highly dynamic motion of crown ethers along oligolysine peptide chains

H/D exchange reactions in the high vacuum of a mass spectrometer reveal how crown ethers move between ammonium ion binding sites of an oligolysine peptide. This study enables the dynamics of non-covalent interactions to be probed in a unique environment and could be applied to more complex artificial or natural systems.

Dominik P. Weimann
Henrik D. F. Winkler
Christoph A. Schalley
Research30 Aug 2009
Nature Chemistry

Volume: 1, P: 573-577
Atlantic Equatorial Undercurrent intensification counteracts warming-induced deoxygenation

Recent strengthening of the Equatorial Undercurrent counteracts warming-induced deoxygenation in the equatorial Atlantic, according to an analysis of long-term moored observations.

Peter Brandt
Johannes Hahn
Marcus Dengler
Research19 Apr 2021
Nature Geoscience

Volume: 14, P: 278-282
Oxygen Exchange between Nitrous Acid and Water

C. A. BUNTON
D. R. LLEWELLYN
G. STEDMAN
Research08 Jan 1955
Nature

Volume: 175, P: 83-84
Erratum: Highly dynamic motion of crown ethers along oligolysine peptide chains

Dominik P. Weimann
Henrik D. F. Winkler
Christoph A. Schalley
Amendments and Corrections01 Nov 2009
Nature Chemistry

Volume: 1, P: 668
Lay guide to mircobiology

D. E. Hughes
Books & Arts26 Aug 1976
Nature

Volume: 262, P: 824
Value of π

D. F. FERGUSON
Research16 Mar 1946
Nature

Volume: 157, P: 342
Active energy compression of a laser-plasma electron beam

A laser-plasma electron beam generated using active energy compression demonstrates reduction in energy spread and jitter by an order of magnitude to below the permille level, comparable with modern radio-frequency accelerators.

P. Winkler
M. Trunk
A. R. Maier
ResearchOpen Access09 Apr 2025
Nature

Volume: 640, P: 907-910
Intramembraneous changes on cationophore-triggered exocytosis in Paramecium

HELMUT PLATTNER
Research20 Dec 1974
Nature

Volume: 252, P: 722-724
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Genomic analyses of large population-based cohorts uncover the genetic determinants of perivascular space burden, an MRI marker of cerebral small vessel disease, across the lifespan, and reveal potential pathways implicated in the etiology of stroke and dementia.

Marie-Gabrielle Duperron
Maria J. Knol
Stéphanie Debette
ResearchOpen Access17 Apr 2023
Nature Medicine

Volume: 29, P: 950-962
Transformation of mononuclear phagocytes in vivo and malignant histiocytosis caused by a novel murine spleen focus-forming virus

T. Franz
J. Löhler
W. Ostertag
Research09 May 1985
Nature

Volume: 315, P: 149-151
Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor

N. Borkakoti
F.K. Winkler
E.J. Murray
Research01 Feb 1994
Nature Structural Biology

Volume: 1, P: 106-110
Budgetary and biogeochemical implications of N₂O isotope signatures in the Arabian Sea

S. W. A. Naqvi
T. Yoshinari
L. A. Codispoti
Research30 Jul 1998
Nature

Volume: 394, P: 462-464
Decoding drivers of carbon flux attenuation in the oceanic biological pump

In situ experimental findings from six contrasting oceanic regimes, at multiple mesopelagic depths, are used to determine the mechanisms that drive microbially mediated carbon flux attenuation in the oceanic biological pump.

M. Bressac
E. C. Laurenceau-Cornec
P. W. Boyd
ResearchOpen Access11 Sept 2024
Nature

Volume: 633, P: 587-593
Inhibition of Membrane Permeability to Chloride by Copper in Molluscan Neurones

D. J. CHIARANDINI
E. STEFANI
H. M. GERSCHENFELD
Research07 Jan 1967
Nature

Volume: 213, P: 97-99
Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records

Here, the authors identify six genetic variants associated with adult weight-change, by leveraging 24.5 million weight records from the UK, USA, and Estonia. These variants influence weight change independently of baseline weight.

Samvida S. Venkatesh
Habib Ganjgahi
George Nicholson
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-19
Discovery of 69 ms periodic X-ray pulsations in A0538 — 66

G. K. Skinner
D. K. Bedford
J. Grindlay
Research17 Jun 1982
Nature

Volume: 297, P: 568-570
Acute hepatic injury by vinyl chloride in rats pretreated with phenobarbital

RUDOLPH J. JAEGER
EDWARD S. REYNOLDS
SHELDON D. MURPHY
Research20 Dec 1974
Nature

Volume: 252, P: 724-726
Laser amplification in excited dielectrics

Ultrashort high-intensity laser pulses change the properties of dielectrics in different ways. One unexpected outcome is light amplification in an excited dielectric, observed in a two-colour pump–probe experiment.

Thomas Winkler
Lasse Haahr-Lillevang
Thomas Baumert
Research18 Sept 2017
Nature Physics

Volume: 14, P: 74-79
Problems in Parthenogenesis

A. D. PEACOCK
Research05 Dec 1931
Nature

Volume: 128, P: 941-943
Disruption of formin-encoding transcripts in two mutant limb deformity alleles

Richard L. Maas
Rolf Zeller
Philip Leder
Research30 Aug 1990
Nature

Volume: 346, P: 853-855
Global diversity and distribution of antibiotic resistance genes in human wastewater treatment systems

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Congmin Zhu
Linwei Wu
Jizhong Zhou
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-14
An unusual buried polar cluster in a family of fungal lipases

U. Derewenda
L. Swenson
Z.S. Derewenda
Research01 Jan 1994
Nature Structural Biology

Volume: 1, P: 36-47
The deepwater oxygen deficit in stratified shallow seas is mediated by diapycnal mixing

Oxygen deprivation in the marine environment is likely to be exacerbated by climate change. We present data to show the potential impact of changing weather patterns in the development of a seasonal oxygen deficit in seasonally stratifying shelf seas.

Tom Rippeth
Sijing Shen
Jonathan Sharples
ResearchOpen Access11 Apr 2024
Nature Communications

Volume: 15, P: 1-9
Quantification of human contribution to soil moisture-based terrestrial aridity

Historical latitudinal and seasonal trends in global soil moisture aridity are attributable to greenhouse gas emissions.

Yaoping Wang
Jiafu Mao
Yongjiu Dai
ResearchOpen Access11 Nov 2022
Nature Communications

Volume: 13, P: 1-11
Deep oceans may acidify faster than anticipated due to global warming

Changes in deep-water ventilation could potentially cause acidification from organic matter breakdown. The Sea of Japan has an acidification rate 27% higher at depth than at the surface, showing how reduced ventilation from warming could impact the deep ocean.

Chen-Tung Arthur Chen
Hon-Kit Lui
Gwo-Ching Gong
Research27 Nov 2017
Nature Climate Change

Volume: 7, P: 890-894
Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)

A. Berling-Ernst
M. Yahiaoui-Doktor
M. Halle
ResearchOpen Access21 Feb 2022
Scientific Reports

Volume: 12, P: 1-7
Use of expert judgment in exposure assessment: Part 2. Calibration of expert judgments about personal exposures to benzene

Katherine D Walker
Paul Catalano
John S Evans
Research01 Jan 2003
Journal of Exposure Science & Environmental Epidemiology

Volume: 13, P: 1-16
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Towards optimal single-photon sources from polarized microcavities

Single-photon sources with a single-photon efficiency of 0.60, a single-photon purity of 0.975 and an indistinguishability of 0.975 are demonstrated. This is achieved by fabricating elliptical resonators around site-registered quantum dots.

Hui Wang
Yu-Ming He
Jian-Wei Pan
Research05 Aug 2019
Nature Photonics

Volume: 13, P: 770-775
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Multiancestry genome-wide association analyses identify new risk loci for stroke and stroke subtypes. Fine mapping and bioinformatics analyses of these risk loci point to mechanisms not previously implicated in stroke pathophysiology.

Rainer Malik
Ganesh Chauhan
Martin Dichgans
Research12 Mar 2018
Nature Genetics

Volume: 50, P: 524-537
Characterization of single neurons reprogrammed by pancreatic cancer

A technique that combines retrograde axon tracing with single-cell transcriptomics is used to characterize neurons innervating pancreatic ductal adenocarcinoma and healthy pancreas, providing insight into the role of neural connections in cancer progression.

Vera Thiel
Simon Renders
Andreas Trumpp
ResearchOpen Access17 Feb 2025
Nature

Volume: 640, P: 1042-1051
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Amy R. Bentley
Yun J. Sung
L. Adrienne Cupples
Research29 Mar 2019
Nature Genetics

Volume: 51, P: 636-648
Behaviour of Single Wood Fibres under Axial Tensile Strain

D. H. PAGE
F. EL-HOSSEINY
K. WINKLER
Research22 Jan 1971
Nature

Volume: 229, P: 252-253
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

Olivier Delattre
Jessica Zucman
Gilles Thomas
Research10 Sept 1992
Nature

Volume: 359, P: 162-165
Deoxygenation alters bacterial diversity and community composition in the ocean’s largest oxygen minimum zone

Oxygen minimum zones in the global ocean have an important role in biogeochemical cycles, yet their response to climate change is poorly understood. Here, the authors show that bacterial community composition is tightly coupled to dissolved oxygen and is likely to fundamentally change as the oceans warm.

J. Michael Beman
Molly T. Carolan
Research28 Oct 2013
Nature Communications

Volume: 4, P: 1-11
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

Tuomas O. Kilpeläinen
Amy R. Bentley
Ruth J. F. Loos
ResearchOpen Access22 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Anthropogenic organic aerosol in Europe produced mainly through second-generation oxidation

Second-generation oxidation boosts the production of anthropogenic organic aerosol, according to an analysis of urban haze in an experimental chamber.

Mao Xiao
Mingyi Wang
Imad El Haddad
ResearchOpen Access10 Mar 2025
Nature Geoscience

Volume: 18, P: 239-245
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Increased Urinary Pseudouridine Excretion in Rats following Irradiation

D. DRAHOVSKÝ
A. WINKLER
J. ŠKODA
Research25 Jan 1964
Nature

Volume: 201, P: 411-412
Doppler ultrasonography of the central retinal artery in normals treated with topical timolol

R D Steigerwalt Jr
G Belcaro
M Milazzo
Research01 May 1993
Eye

Volume: 7, P: 403-406

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