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Surface dynamics play a central role in the biological function of natural supramolecular structures. Here, the authors investigate the nanoscale dynamics at the surface of synthetic nanostructure using binding affinity to surface bound chelators.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Xuejun Zhang, Jun Wang, Liangdan Sun, Lennart Hammarström and colleagues sequence the MHC region in 20,635 Han Chinese individuals. Their Han-MHC database allows identification of new susceptibility loci for psoriasis and could serve as a tool for investigating the role of the MHC region in other complex diseases.

A large magnetic field induces a metal-insulator transition in graphite, which manifests as a dome in the phase diagram. Ye et al. show that this dome is an example of an electron-hole pair BCS-BEC crossover, tuneable by hydrostatic pressure with a locked summit temperature.

The growth of monolayer hexagonal boron nitride (hBN) on insulating substrates could promote high-end applications of 2D (opto-)electronic devices, but remains difficult to achieve. Here, the authors report a stamp-like growth-transfer technique to produce inch-sized single-crystal hBN and graphene monolayers on various insulating substrates.

Magnetostriction refers to the contraction or expansion of the crystal lattice of a magnetic material when a magnetic field is applied. Here, Meng et al show that Mn₃Sn, a noncollinear antiferromagnet, hosts a large linear magnetostriction, which is driven by the field induced in-plane rotation of spins.

The authors reprogram chicken fibroblast cells to form primordial germ cells (PGCs) in one species (black feather Langshan chicken) and then show such PGCs can be transplanted and migrate into the genital ridge of another chicken species (White Plymouth Rock) to produce viable offspring with the Characteristics of donor.

Different types of lytic cell death can trigger an anti-tumor immune response. Here the authors report the design of a near infrared light controllable micron-scale oncolytic system, triggering lipid peroxidation and lytic cell death in tumors as well anti-tumor immunity in preclinical cancer models.

Individuals with SYK gain-of-function variants develop immunodeficiency and systemic inflammation, which are recapitulated in a knock-in mouse model. Treatment of these mice with bone marrow transplantation or with a SYK inhibitor ameliorates disease symptoms, highlighting potential therapeutic strategies for patients with SYK mutations.

Analysis of CRISPR-Cas off-targets is important. Here the authors incorporate molecular dynamics simulations in the computational analysis of CRISPR editing and report the CRISOT tool suite and apply this to genome-wide CRISPR off-target prediction and sgRNA optimisation.

The glassy materials show a few layers of molecules at the outmost surface which are in a mobile state while the molecules in the glass interior remain frozen, but manipulation of this outer layer remains challenging. Here, the authors provided a strategy to tune the mobility of the surface layer by devising polymer surfaces occupied by chain loops of various penetration depths.

The large-area growth of 2D transition metal dichalcogenides (TMDs) requires a precise control of metal and chalcogen precursors. Here, the authors implement a strategy using active chalcogen monomer supply to grow monolayer TMDs and their alloys, showing low defect density and improved optoelectronic properties.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

Evidence from large longitudinal neuroimaging cohorts, which include genetic and behavioral data, suggest a common neural basis for symptoms seen across multiple psychiatric disorders.

The Human Muscle Ageing Cell Atlas provides a series of integrated cellular and molecular explanations for sarcopenia and frailty development in advanced ages.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

Post-acute sequelae of COVID-19 (PASC) has heterogenous presentation and complex etiology. Here the authors profile peripheral blood of patients with PASC and analyze by machine-learning to identify immune and serology features that allow the stratification of PASC into inflammatory and non-inflammatory types for better diagnosis and therapy-planning.

Fundamental investigations at the electrode/electrolyte interface are essential for developing high-energy batteries. Here, the authors investigate the degradation mechanisms at the LGPS/NCM622 interface providing a quantitative model to interpret the interfacial resistance growth.

Dutta et al. show that impaired mitochondrial fatty acid synthesis (mtFAS) leads to neurodegeneration, increased ceramide levels and disturbed iron metabolism in flies and in fibroblasts from individuals with a mutation in an mtFAS enzyme.

Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated.

Developmental potential of oocytes decreases in women of advanced age. Here the authors observe impaired meiosis-coupled mRNA decay and reduced CXXC1-maintained histone H3K4 trimethylation in old oocytes of mouse and humans.

A multi-omic analysis of pancreatic cancer identifies spatially resolved, heterogeneous cell populations including transitional cell types. Analysis of primary samples identifies treatment-related changes in cross-talk between tumor and stromal cells.

RNA polymerase II (Pol II) transcription factories play a central role in gene expression and 3D chromatin organization. Here, the authors demonstrate that RUVBL2 directly regulates Pol II clustering at active gene promoters.

Understanding the photoelectron emission time after the interaction of photon with atoms and molecules is of fundamental interest. Here the authors examine the role of partial waves to the photoionization phase shift of atoms using an attosecond clock and electron-ion coincidence spectroscopy.

Photoredox catalysis has emerged as an indispensable platform for de novo synthesis and modification of complex biologically relevant molecules. This Review highlights photoredox-mediated C–H and C–C bond activation of carbohydrates leading to non-conventional C-functionalized sugars and rare sugar isomers.

Recent studies show that Hsp70 chaperones associate with ribosomes not only in yeast but also in humans. Differences seem to exist among species regarding the identities of Hsp70 homologs involved as well as the mechanisms of their ribosomal recruitment and activation.

Xu et al. show that satellite-measured urbanicity (living in a densely populated area) is correlated with brain volume, cortical surface area and brain network connectivity in a sample of 3,867 people from China and Europe.

Suppressed Dexter transfer is needed to achieve efficient and stable hyperfluorescence, but complex matrices must be involved. A molecular design strategy has been proposed where Dexter transfer can be substantially reduced by an encapsulated terminal emitter, leading to ‘matrix-free’ hyperfluorescence.

PHDGH heterogeneity in primary tumours could be a sign of tumour aggressiveness.

Iron metabolism dysregulation is associated with various diseases including cancer. Here, the authors show that one iron-triggered lncRNA LncRIM regulates cellular iron metabolism effectively by wiring up the Hippo-YAP  signaling pathway and promotes breast cancer development.

Errors in vascular development are associated with several congenital defects. Here they systematically investigated the epigenetic landscape of the endothelial lineage and found that MECOM depletion impairs endothelial cell differentiation and angiogenesis.

Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca²⁺ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates proton sensitivity and contributes to the Ca²⁺ block.

Two draft sequences of Gossypium hirsutum, the most widely cultivated cotton species, provide insights into genome structure, genome rearrangement, gene evolution and cotton fiber biology.