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Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial

In this phase IV trial, the authors assessed antibody responses to multiple vaccines in the same individuals of different age groups and show that the responsiveness to different vaccines was highly variable but that a small group of older male adults responded low to multiple vaccines.
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Marieke van der Heiden
Sudarshan Shetty
Debbie van Baarle
ResearchOpen Access04 Aug 2024
Nature Communications

Volume: 15, P: 1-13
IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

Few studies have suggested that enteric glial cells (EGCs) promote colorectal cancer growth. Here the authors show that EGC-derived IL-6 promotes the expansion of tumorigenic SPP1⁺ tumor-associated macrophages, associated with worse disease outcome.

Lies van Baarle
Veronica De Simone
Gianluca Matteoli
ResearchOpen Access19 Jul 2024
Nature Communications

Volume: 15, P: 1-22
Original COVID-19 priming regimen impacts the immunogenicity of bivalent BA.1 and BA.5 boosters

Waning immunity and the emergence of the SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness and required vaccine updates. Here, the authors assess how different priming regimens affect the immunogenicity of BA.1 and BA.5 bivalent boosters.

Luca M. Zaeck
Ngoc H. Tan
Rory D. de Vries
ResearchOpen Access18 May 2024
Nature Communications

Volume: 15, P: 1-12
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Preserved measles immunity after allogeneic hematopoietic stem cell transplantation in a cohort of mainly αβ T-cell-depleted graft recipients

M. J. M. Janssen
M. A. de Witte
A.H.W. Bruns
Correspondence06 Oct 2025
Bone Marrow Transplantation

P: 1-3
Author Correction: Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

Marta Reyman
Marlies A. van Houten
Debby Bogaert
Amendments and CorrectionsOpen Access25 Nov 2019
Nature Communications

Volume: 10, P: 1
Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination

The establishment and composition of the host microbiota is known to impact the function of the host immune response. Here the authors show that mode of delivery may impact the intestinal microbiota composition from birth and modulate the response to routine childhood vaccines.

Emma M. de Koff
Debbie van Baarle
Susana Fuentes
ResearchOpen Access15 Nov 2022
Nature Communications

Volume: 13, P: 1-12
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa

Cell-type-specific SARS-CoV-2-induced responses in nasal mucosa differ largely between ancestral, Delta and Omicron cases, including the association with severe disease and the cellular and immunological effects of prior vaccination.

Debbie van Baarle
Martijn C. Nawijn
News & Views29 Jan 2025
Nature Immunology

Volume: 26, P: 152-154
Effects of ageing and frailty on circulating monocyte and dendritic cell subsets

Rosanne D. Reitsema
Ashok K. Kumawat
Yannick van Sleen
ResearchOpen Access04 Mar 2024
npj Aging

Volume: 10, P: 1-6
Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

Here, in a cohort of infants unexposed to maternal antibiotics, the authors analyse the gut microbiome development of children born naturally and by caesarean section, finding a higher abundance of known pathogens in the latter group, and an association between these bacteria and a higher incidence of respiratory infections in the first year of life.

Marta Reyman
Marlies A. van Houten
Debby Bogaert
ResearchOpen Access01 Nov 2019
Nature Communications

Volume: 10, P: 1-12
Age-related decline in IgM responses associate with reduced opsonophagocytic activity following PCV13 vaccination

M. Visser
J. van Beek
A. M. Buisman
ResearchOpen Access14 May 2025
npj Vaccines

Volume: 10, P: 1-13
Delineating immune variation between adult and children COVID-19 cases and associations with disease severity

Alper Cevirgel
Martijn Vos
Jelle de Wit
ResearchOpen Access01 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
Dietary targeting of TRPM8 rewires macrophage immunometabolism reducing colitis severity

D. Cicia
F. Biscu
AA. Izzo
ResearchOpen Access25 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-16
Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients

Yvette den Hartog
S. Reshwan K. Malahe
Rob van Binnendijk
ResearchOpen Access14 Feb 2024
npj Viruses

Volume: 2, P: 1-10
Modified influenza M1_58–66 peptide vaccination induces non-relevant T-cells and may enhance pathology after challenge

Josien Lanfermeijer
Koen van de Ven
Jørgen de Jonge
ResearchOpen Access12 Aug 2023
npj Vaccines

Volume: 8, P: 1-14
The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients

M. A. Slim
E. H. T. Lim
N. P. Juffermans
ResearchOpen Access20 Apr 2024
Scientific Reports

Volume: 14, P: 1-9
Effect of DMARDs on the immunogenicity of vaccines

Vaccines are important tools for protection against infectious diseases, particularly in patients undergoing immunosuppression (including DMARD therapy). This Review discusses the effects of DMARDs on vaccine immunogenicity, focusing on influenza and SARS-CoV-2 vaccines, and potential mechanisms underlying these effects.

Yannick van Sleen
Kornelis S. M. van der Geest
Elisabeth Brouwer
Reviews12 Jul 2023
Nature Reviews Rheumatology

Volume: 19, P: 560-575
Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling

Serhiy Havrylov
Paul Chrystal
Ordan J. Lehmann
ResearchOpen Access31 Aug 2024
Scientific Reports

Volume: 14, P: 1-16
Th₁-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses

Yvette den Hartog
S. Reshwan K. Malahe
Carla C. Baan
ResearchOpen Access17 May 2023
npj Vaccines

Volume: 8, P: 1-10
Stem cell source-dependent reconstitution of FOXP3+ T cells after pediatric SCT and the association with allo-reactive disease

L L Reubsaet
A P J de Pagter
I M de Kleer
Research24 Sept 2012
Bone Marrow Transplantation

Volume: 48, P: 502-507
Human herpes virus 6 reactivation: important predictor for poor outcome after myeloablative, but not non-myeloablative allo-SCT

P J A de Pagter
R Schuurman
J J Boelens
Research17 Jun 2013
Bone Marrow Transplantation

Volume: 48, P: 1460-1464
Associations and recovery dynamics of the nasopharyngeal microbiota during influenza-like illness in the aging population

Sudarshan A. Shetty
Josine van Beek
Susana Fuentes
ResearchOpen Access03 Feb 2022
Scientific Reports

Volume: 12, P: 1-13
Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1

R Oostvogels
M C Minnema
T Mutis
ResearchOpen Access01 Oct 2012
Leukemia

Volume: 27, P: 642-649
Response kinetics reveal novel features of ageing in murine T cells

Daan K. J. Pieren
Noortje A. M. Smits
Teun Guichelaar
ResearchOpen Access03 Apr 2019
Scientific Reports

Volume: 9, P: 1-13
γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia

W Scheper
S van Dorp
J Kuball
Research01 Jan 2013
Leukemia

Volume: 27, P: 1328-1338

Search

Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

Original COVID-19 priming regimen impacts the immunogenicity of bivalent BA.1 and BA.5 boosters

Mapping the human genetic architecture of COVID-19

Preserved measles immunity after allogeneic hematopoietic stem cell transplantation in a cohort of mainly αβ T-cell-depleted graft recipients

Author Correction: Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination

Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa

Effects of ageing and frailty on circulating monocyte and dendritic cell subsets

Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

Age-related decline in IgM responses associate with reduced opsonophagocytic activity following PCV13 vaccination

Delineating immune variation between adult and children COVID-19 cases and associations with disease severity

Dietary targeting of TRPM8 rewires macrophage immunometabolism reducing colitis severity

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients

Modified influenza M1_58–66 peptide vaccination induces non-relevant T-cells and may enhance pathology after challenge

The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients

Effect of DMARDs on the immunogenicity of vaccines

Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling

Th₁-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses

Stem cell source-dependent reconstitution of FOXP3+ T cells after pediatric SCT and the association with allo-reactive disease

Human herpes virus 6 reactivation: important predictor for poor outcome after myeloablative, but not non-myeloablative allo-SCT

Associations and recovery dynamics of the nasopharyngeal microbiota during influenza-like illness in the aging population

Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1

Response kinetics reveal novel features of ageing in murine T cells

γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia

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