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The high thermal conductivity of graphene is considerably reduced when the two-dimensional material is in contact with a substrate. Here, the authors show that thermal management of a micro heater is improved using graphene-based films covalently bonded by amino-silane molecules to graphene oxide.

Simultaneous observations of TRAPPIST-1 b from JWST at 12.8 and 15 μm indicate that it is probably a bare rock with a mineral-rich surface. However, an alternative scenario with a CO₂-rich atmosphere and hazes could also explain the observations.

Testicular germ cell tumours (TGCT) are the most common cancers in young men. Here, the authors analyse the genomic landscape of TGCT using data from the Genomics England 100,000 Genomes Project, revealing divergent evolutionary trajectories and the prevalence of human leukocyte antigen loss.

Mismatch repair-deficient colorectal cancer clones adapt their mutation landscape by toggling homopolymer sequences in MutS homolog 3 (MSH3) and MutS homolog 6 (MSH6). This increases the subclonal mutation rate and clonal diversity, favoring immune escape and tumor growth.

3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.

Here the authors demonstrate ultraviolet astronomical frequency combs, derived from the near-infrared domain via efficient harmonic generation in nanophotonic waveguides, to provide precision calibration to astronomical spectrographs for exoplanet science and precision cosmology.

Evolutionary analysis of swine-origin H1N1 influenza A virus provides evidence that it was derived from several viruses circulating in swine and that it possesses genes from avian, swine and human origin. Furthermore, transmission to humans may have occurred several months before recognition of the current outbreak.

Superconducting giant atoms are realized in a waveguide by coupling small atoms to the waveguide at multiple discrete locations, producing tunable atom–waveguide coupling and enabling decoherence-free interactions.

Chromosome-scale sequence assemblies of 20 diverse varieties of barley are used to construct a first-generation pan-genome, revealing previously hidden genetic variation that can be used by studies aimed at crop improvement

We report the experimental observation of one- and two-dimensional grating patterns formed in a disordered metal-nanoparticle layer by a single light pulse. The phenomenon is attributed to interference effects between the incident light and waveguided modes. Such self-patterning behaviour could be useful for the fabrication of complex nanostructures and advanced photonic devices.

The integration of microarray and metabolite data is important for understanding the physiology of model organisms. This study demonstrates how the integration of these kinds of data can provide novel insights into the growth and protein metabolism of two different yeast strains.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

Casimir forces are normally attractive and cause stiction, that is, static friction preventing surfaces in contact from starting to move. Now, a system exhibiting tunable repulsive critical Casimir forces, relevant for the development of micro- and nanodevices, is demonstrated.

Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.

Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be achieved.

Here, Schoeler et al. investigate how interaction between dietary lipids and the gut microbiota affect hepatic steatosis and host metabolism, showing that dietary lipids impact the gut microbiota composition independent on fiber intake in humans and mice.

Engineering the biosynthesis, compartmentalization and recycling of three cofactors enables increased production of caffeic acid and ferulic acid in yeast, suggesting that these strategies could improve metabolic flux to other desirable compounds.

JWST observations of the planetary nebula NGC 3132 reveal a rich molecular environment containing evidence of multiple stellar interactions on a variety of scales.

The hydroxyl radical OH has been detected in a planet-forming disk exposed to ultraviolet radiation and in a rovibrationally excited state. These JWST observations, when coupled with quantum calculations, reveal the ongoing photodissociation of water and its reformation in the gas phase.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Interactions of atmospheric neutrinos with quantum-gravity-induced fluctuations of the metric of spacetime would lead to decoherence. The IceCube Collaboration constrains such interactions with atmospheric neutrinos.

For active particles with nanoscale dimensions the overwhelming rotational diffusivity usually masks their residual non-equilibrium character. Here Schmidt et al. show how to amplify it in a suitable experiment to let a nanosphere rotate spontaneously around the beam axis in an optical trap.

Phase-resolved mid-infrared observations from JWST of the hot gas giant WASP-43b detect a day–night difference of 659 ± 19 K. Comparison with climate models shows that the observations are compatible with cloudy skies, at least on the nightside, and the lack of methane detection suggests the presence of disequilibrium chemistry.

Spectrally and spatially resolved ALMA observations of water vapour in the inner regions of the famous planet-forming disk around HL Tauri pave the way towards an observational characterization of planet formation at the water snowline.

The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineage Kinase Domain-Like (MLKL).

Integrated analysis of bacterial, fungal and microbial communities in the airways of patients with bronchiectasis demonstrates that interaction networks, rather than the relative abundance of any single microbial species, are associated with exacerbation risk.

Neurons form glutamatergic synapses with glioma cells in mice and humans, and inhibition of AMPA receptors reduces glioma cell invasion and growth.

A new study examines microbiome-generated ethanol in individuals with and without nonalcoholic fatty liver disease (NAFLD), concluding that microbial ethanol might contribute to pathogenesis in some patients with NAFLD.

In metabolic engineering, mechanistic models require prior metabolism knowledge of the chassis strain, whereas machine learning models need ample training data. Here, the authors combine the mechanistic and machine learning models to improve prediction performance of tryptophan metabolism in baker’s yeast.

Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin. Here, the authors show that lncRNA MEG3regulates the TGF-β pathway by bridging the interactions between polycomb repressive complex 2 and the distal regulatory elements of the TGF-β pathway genes via formation of RNA–DNA triplexes.

Phage engineered with tail fibers and CRISPR–Cas reduce Escherichia coli load in animals.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Observations from the JWST MIRI showed the detection of ¹⁴NH₃ and ¹⁵NH₃ isotopologues in the atmosphere of a cool brown dwarf, along with a ¹⁴N/¹⁵N value consistent with star-like formation by gravitational collapse.

The new European X-Ray Free-Electron Laser (EuXFEL) is the first XFEL that generates X-ray pulses with a megahertz inter-pulse spacing. Here the authors demonstrate that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using lysozyme as a test case and furthermore present a β-lactamase structure.

 Observations with the sensitive mid-infrared spectrometer MIRI on board JWST reveal the presence of a water vapour reservoir in the terrestrial plant-forming zone of the young planetary system PDS 70.

When stars like our Sun die, they expel their outer layers in a dramatic stellar wind. This study of an unusual chemical signature in one particular stellar wind reveals that the signature is due to the presence of a binary system whose components had a close approach around 200 years ago.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Observation of ²⁸O and ²⁷O through their decay into ²⁴O and four and three neutrons, respectively, is reported, with the ²⁸O nucleus being of particular interest owing to proton and neutron magic numbers and its extremely asymmetric neutron-to-proton ratio.

Experiments on an YBa₂Cu₃O_7−δ nano-island reveal fundamental information about the order parameter in this type of high-temperature superconducting material.

By coupling a superconducting qubit to surface acoustic waves the ‘giant atom’ regime is realized, where an atom is coupled to a field with wavelength orders of magnitude smaller than the atomic size. This leads to non-Markovian qubit dynamics.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Excitations of the fractional quantum Hall states are of great interest because they obey anyonic statistics, but electronic interferometers give contrasting results about their quantum coherence. Here the authors use novel two-particle time-domain interferometry to show that quantum coherence is indeed preserved.

Direct detection of gas phase water from the disk of V883 Ori indicates that disks directly inherit water from the star-forming cloud that becomes incorporated into large icy bodies without notable chemical alteration.