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Mapping the evolving strain field during continental breakup from crustal anisotropy in the Afar Depression

The spatial and temporal scales over which continental breakup occurs by mechanical deformation and magma intrusion remain controversial. Keiret al. quantify anisotropy across the Afar Triple Junction using S-wave splitting from earthquakes to evaluate the strain in a region of continental breakup.

Derek Keir
M. Belachew
J.V. Rowland
ResearchOpen Access19 Apr 2011
Nature Communications

Volume: 2, P: 1-7
The Lunar Society of Birmingham

D. G. KING-HELE
News15 Oct 1966
Nature

Volume: 212, P: 229-233
Effect of deep-sea sedimentary calcite preservation on atmospheric CO₂ concentration

D. Archer
E. Maier-Reimer
Research20 Jan 1994
Nature

Volume: 367, P: 260-263
Vostok ice core provides 160,000-year record of atmospheric CO₂

J. M. Barnola
D. Raynaud
C. Lorius
Research01 Oct 1987
Nature

Volume: 329, P: 408-414
Efficacy of ‘Viractin’ in Preventing Respiratory Disease

D. A. J. TYRRELL
GEORGINA H. WALKER
Research23 Apr 1966
Nature

Volume: 210, P: 386-387
In situ electrical resistivity and bulk porosity of the oceanic crust Costa Rica Rift

Keir Becker
R. P. Von Herzen
R. L. Newmark
Research16 Dec 1982
Nature

Volume: 300, P: 594-598
γ Endorphin, α endorphin and Met-enkephalin are formed extracellularly from lipotropin C fragment

B. M. AUSTEN
D. G. SMYTH
C. R. SNELL
Research01 Oct 1977
Nature

Volume: 269, P: 619-621
Younger Dryas glacier advances in the tropical Andes driven by increased precipitation

Neil F. Glasser
Stephan Harrison
Manuel Cosi
ResearchOpen Access22 Aug 2025
Scientific Reports

Volume: 15, P: 1-8
Differential Response to Mutagens in Arabidopsis thaliana

A. D. McKELVIE
Research28 Jul 1962
Nature

Volume: 195, P: 409-410
Vostok ice core: climatic response to CO₂ and orbital forcing changes over the last climatic cycle

G. Genthon
J. M. Barnola
V. M. Kotlyakov
Research01 Oct 1987
Nature

Volume: 329, P: 414-418
Give UK science the overhaul it urgently needs

Five scholars share their science-policy priorities for the incoming government as it faces urgent challenges in tackling climate change, health, inequality and more.

Marie Claire Brisbois
Furaha Asani
Maria Nedeva
Comments & Opinion04 Jul 2024
Nature

Volume: 631, P: 271-274
The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis

Hegazy and colleagues demonstrate that epithelial oncostatin M receptor expression drives gut inflammation and tumor formation.

Roodline Cineus
Yanjiang Luo
Ahmed N. Hegazy
ResearchOpen Access30 May 2025
Nature Immunology

Volume: 26, P: 837-853
Enzymes of the human cervix uteri. Comparison of nucleases and adenosine deaminase in malignant and non-malignant tissue samples.

D M Goldberg
J F Pitts
Research01 Dec 1966
British Journal of Cancer

Volume: 20, P: 729-742
The multilayered transcriptional architecture of glioblastoma ecosystems

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with specific mutations that form three stereotypical ecosystems.

Masashi Nomura
Avishay Spitzer
Itay Tirosh
ResearchOpen Access09 May 2025
Nature Genetics

Volume: 57, P: 1155-1167
Enzymatic Digestion of Fibre in Coconut Cake

K. RAMAMURTI
D. S. JOHAR
Research04 May 1963
Nature

Volume: 198, P: 481-482
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics

Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive heterogeneity and microenvironmental co-evolution.

Avishay Spitzer
Kevin C. Johnson
Mario L. Suvà
ResearchOpen Access09 May 2025
Nature Genetics

Volume: 57, P: 1168-1178
Metabolomics strategy for diagnosing urinary tract infections

Microbial catabolites in urine provide a rapid method for detecting urinary tract infections (UTIs). Here, the authors describe an LC-MS metabolomics approach for detecting two catabolites collectively produced by 90% of UTI microbes.

Carly C. Y. Chan
Daniel B. Gregson
Ian A. Lewis
ResearchOpen Access18 Mar 2025
Nature Communications

Volume: 16, P: 1-10
Synthesis of Diphosphopyridine Nucleotide in Irradiated Rats

D. K. MYERS
Research24 Sept 1960
Nature

Volume: 187, P: 1124-1125
DSDP Hole 504B, the first reference section over 1 km through Layer 2 of the oceanic crust

R. N. Anderson
J. Honnorez
R. L. Newmark
Research16 Dec 1982
Nature

Volume: 300, P: 589-594
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Intraventricularly delivered monovalent and trivalent CAR T cells exhibit greater therapeutic efficacy as compared with intravenously delivered CAR T cells in medulloblastoma xenograft mouse models and show potency in ependymoma xenograft mouse models.

Laura K. Donovan
Alberto Delaidelli
Michael D. Taylor
Research27 Apr 2020
Nature Medicine

Volume: 26, P: 720-731
Glacial-to-interglacial variations in the carbon isotopic composition of atmospheric CO₂

Bruno D. Marino
Michael B. McElroy
W. Geoffrey Spaulding
Research11 Jun 1992
Nature

Volume: 357, P: 461-466
X-ray analyses of peptide–inhibitor complexes define the structural basis of specificity for human and mouse renins

V. Dhanaraj
C. G. Dealwis
D. J. Hoover
Research11 Jun 1992
Nature

Volume: 357, P: 466-472
Ice-core record of atmospheric methane over the past 160,000 years

J. Chappellaz
J. M. Barnola
C. Lorius
Research10 May 1990
Nature

Volume: 345, P: 127-131
The Lunar Society

D. G. King-Hele
News01 Jan 1968
Nature

Volume: 217, P: 211-212
Simultaneous rift-scale inflation of a deep crustal sill network in Afar, East Africa

This study shows that magma rising from deep in the Earth’s mantle is not a continuous process but occurs in episodes. This is observed in East Africa with simultaneously replenishing of four magma pockets.

A. La Rosa
C. Pagli
D. Keir
ResearchOpen Access20 May 2024
Nature Communications

Volume: 15, P: 1-8
Enhanced particle fluxes in Bay of Bengal induced by injection of fresh water

V. Ittekkot
R. R. Nair
B. N. Desai
Research30 May 1991
Nature

Volume: 351, P: 385-387
Nucleases, adenosine deaminase, and dehydrogenases in malignant and non-malignant lesions of the female breast.

D M Goldberg
J F Pitts
H A Ayre
Research01 Jun 1967
British Journal of Cancer

Volume: 21, P: 312-321
Eruptive and diffuse emissions of CO₂ from Mount Etna

P. Allard
J. Carbonnelle
P. Zettwoog
Research30 May 1991
Nature

Volume: 351, P: 387-391
High concentration of atmospheric ¹⁴C during the Younger Dryas cold episode

Tomasz Goslar
Maurice Arnold
Kazimierz Wiȩqkowski
Research05 Oct 1995
Nature

Volume: 377, P: 414-417
Evidence for lower productivity in the Antarctic Ocean during the last glaciation

R. A. Mortlock
C. D. Charles
L. H. Burckle
Research16 May 1991
Nature

Volume: 351, P: 220-223
Changes in copper, zinc and cadmium concentration in Antarctic ice during the past 40,000 years

Françoise Batifol
Claude Boutron
Martine de Angelis
Research09 Feb 1989
Nature

Volume: 337, P: 544-546
Palaeoclimatological and chronological implications of the Vostok core dust record

J. R. Petit
L. Mourner
C. Lorius
Research04 Jan 1990
Nature

Volume: 343, P: 56-58
Heterogeneous Labelling of Acid-soluble Nucleoside 5′-Monophosphates during Short in vivo Incubation with Phosphate-³²P

T. D. PRICE
K. K. TSUBOI
P. B. HUDSON
Research09 Apr 1960
Nature

Volume: 186, P: 158-160
Atmospheric P CO₂ changes recorded in lake sediments

D. Lal
R. Revelle
Research22 Mar 1984
Nature

Volume: 308, P: 344-346
Antibodies to a cell-surface component coded by human chromosome 21 inhibit action of interferon

M. REVEL
D. BASH
F. H. RUDDLE
Research11 Mar 1976
Nature

Volume: 260, P: 139-141
Therapeutic high affinity T cell receptor targeting a KRAS^G12D cancer neoantigen

Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering of T cell engaging bispecific protein able to selectively target cancer cells with a high-frequency mutation in the KRAS oncogene.

Andrew Poole
Vijaykumar Karuppiah
Chandramouli Chillakuri
ResearchOpen Access10 Sept 2022
Nature Communications

Volume: 13, P: 1-15
A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue

A mechanical injector that targets tissue by sensing the loss-of-resistance on encountering softer tissue or a cavity can reliably and precisely deliver liquids to the suprachoroidal space, and to other injection-accessible target sites in the body.

Girish D. Chitnis
Mohan K. S. Verma
Jeffrey M. Karp
Research25 Feb 2019
Nature Biomedical Engineering

Volume: 3, P: 621-631
Blood and immune development in human fetal bone marrow and Down syndrome

A single-cell atlas of human fetal bone marrow in healthy fetuses and fetuses with Down syndrome provides insight into developmental haematopoiesis in humans and the transcription and functional differences that occur in Down syndrome.

Laura Jardine
Simone Webb
Muzlifah Haniffa
Research29 Sept 2021
Nature

Volume: 598, P: 327-331
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

Multi-modal profiling reveals major alterations in colonic B cells in patients with ulcerative colitis, including reduced clonal diversity of plasma cells, and suggests that circulating gut-homing plasmablasts could serve as a biomarker for disease activity.

Mathieu Uzzan
Jerome C. Martin
Saurabh Mehandru
Research21 Feb 2022
Nature Medicine

Volume: 28, P: 766-779
Integrative microbiomics in bronchiectasis exacerbations

Integrated analysis of bacterial, fungal and microbial communities in the airways of patients with bronchiectasis demonstrates that interaction networks, rather than the relative abundance of any single microbial species, are associated with exacerbation risk.

Micheál Mac Aogáin
Jayanth Kumar Narayana
Sanjay H. Chotirmall
Research05 Apr 2021
Nature Medicine

Volume: 27, P: 688-699
Off-rift volcanism in rift zones determined by crustal unloading

As continents are stretched apart, deep rift valleys form and volcanoes can erupt both inside and outside of the valley. Numerical modelling suggests that gravitational unloading, caused by thinning of the stretched crust, can deflect rising magma towards the edges of the rift valley, causing off-rift eruptions.

Francesco Maccaferri
Eleonora Rivalta
Valerio Acocella
Research23 Mar 2014
Nature Geoscience

Volume: 7, P: 297-300
Magma-assisted rifting in Ethiopia

J.-M. Kendall
G. W. Stuart
D. Keir
Research13 Jan 2005
Nature

Volume: 433, P: 146-148
Frequent PD-L1 expression in testicular germ cell tumors

C D Fankhauser
A Curioni-Fontecedro
P K Bode
ResearchOpen Access14 Jul 2015
British Journal of Cancer

Volume: 113, P: 411-413
Aborted propagation of the Ethiopian rift caused by linkage with the Kenyan rift

Continuous continental rift zones evolve from enigmatic interactions between individual propagating rift segments. Here, the authors document progressive focusing of tectonic and magmatic activity caused by interactions between the Kenyan and Ethiopian rift segments of the East African Rift.

Giacomo Corti
Raffaello Cioni
Anne Glerum
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-11
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

Alexandra L Young
Razvan V Marinescu
Ansgar J Furst
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-16
The protracted development of the continent–ocean transition in Afar

The timing and style of magmatism and extension during the final stages of continental breakup are uncertain. Analysis of ongoing rifting processes in Ethiopia reveals that after a protracted period of extension by magma intrusion, late-stage breakup is characterized by a final phase of plate stretching and voluminous basalt extrusion.

Ian D. Bastow
Derek Keir
Research13 Mar 2011
Nature Geoscience

Volume: 4, P: 248-250
Accurate de novo design of hyperstable constrained peptides

Computational methods for the de novo design of conformationally restricted peptides produce exceptionally stable short peptides stabilized by backbone cyclization and/or internal disulfide bonds that are promising starting points for a new generation of peptide-based drugs.

Gaurav Bhardwaj
Vikram Khipple Mulligan
David Baker
Research14 Sept 2016
Nature

Volume: 538, P: 329-335
An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish

Macrophages are important for tissue regeneration after injury. Here, using a single cell sequencing approach in a zebrafish injury model, the authors show that macrophages transition through a three stage process during tissue regeneration after hair cell damage.

Nicolas Denans
Nhung T. T. Tran
Tatjana Piotrowski
ResearchOpen Access20 Sept 2022
Nature Communications

Volume: 13, P: 1-15
Volcanism records plate thinning driven rift localization in Afar (Ethiopia) since 2-2.5 million years ago

Rapid and localised changes in plate thinning caused by rifting is the primary control on the spatio-temporal distribution of volcanism in the Afar rift, according to argon dating of volcanic rocks from the Afar Stratoid series in Ethiopia.

Gianmaria Tortelli
Anna Gioncada
Derek Keir
ResearchOpen Access21 May 2025
Communications Earth & Environment

Volume: 6, P: 1-10
Volcanism in the Afar Rift sustained by decompression melting with minimal plume influence

Continental breakup and volcanism in Afar, Africa, has been linked to mantle plume activity. Seismic imaging of the mantle beneath Afar, however, identifies an increase in seismic velocities at shallow depths that is consistent with decompression melting and magmatism in the absence of strong plume activity today.

Catherine A. Rychert
James O. S. Hammond
Graham Stuart
Research29 Apr 2012
Nature Geoscience

Volume: 5, P: 406-409

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