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Showing 501–550 of 757 results

Advanced filters: Author: DAVID ELLIS Clear advanced filters

Congenital cataract and multisystem disorders

Lorraine Cassidy
David Taylor
Research01 May 1999
Eye

Volume: 13, P: 464-473
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Vivianna Van Deerlin and colleagues report that common variants at 7p21 are associated with a subtype of frontotemporal lobar degeneration marked by TDP-43 inclusions. They further show that the risk alleles are associated with elevated brain expression of TMEM106B, which resides at the peak of association on 7p21.

Vivianna M Van Deerlin
Patrick M A Sleiman
Virginia M-Y Lee
Research14 Feb 2010
Nature Genetics

Volume: 42, P: 234-239
Survival of pancreatic cancer cells lacking KRAS function

Pancreatic cancer cells may develop resistance to KRAS inhibitors due to activation of compensatory pathways. In this study, the authors demonstrate that KRAS is dispensable in a subset of pancreatic cancer and that PI3K signalling may have an important role in mediating tumor growth following KRAS inhibition.

Mandar Deepak Muzumdar
Pan-Yu Chen
Tyler Jacks
ResearchOpen Access23 Oct 2017
Nature Communications

Volume: 8, P: 1-19
Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly

The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin filaments mechano-inhibits Cdc12-mediated assembly, which enables proper ring assembly in vivo.

Dennis Zimmermann
Kaitlin E. Homa
David R. Kovar
ResearchOpen Access26 Sept 2017
Nature Communications

Volume: 8, P: 1-13
Metabolomic-guided discovery of cyclic nonribosomal peptides from Xylaria ellisii sp. nov., a leaf and stem endophyte of Vaccinium angustifolium

Ashraf Ibrahim
Joey B. Tanney
Mark W. Sumarah
ResearchOpen Access12 Mar 2020
Scientific Reports

Volume: 10, P: 1-17
Protein tyrosine phosphatases take off

Protein tyrosine phosphatases (PTPs) are a family of signal transduction enzymes that dephosphorylate phosphotyrosine containing proteins. Structural and kinetic studies provide a molecular understanding of how these enzymes regulate a wide range of intracellular processes.

David Barford
Zongchao Jia
Nicholas K. Tonks
Reviews01 Dec 1995
Nature Structural Biology

Volume: 2, P: 1043-1053
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

David Hunter and colleagues report results of the CGEMS multistage genome-wide association study of breast cancer. They identify two new risk variants on chromosomes 1p11.2 and 14q24.1, and confirm several previously reported breast cancer risk loci.

Gilles Thomas
Kevin B Jacobs
David J Hunter
Research29 Mar 2009
Nature Genetics

Volume: 41, P: 579-584
‘This kind of narrative has real-world implications for individual patients and broader public perceptions about the push and pull factors driving dental tourism'

David Westgarth
Comments & Opinion07 Apr 2025
BDJ In Practice

Volume: 38, P: 106-107
The Scottish RD survey 10 years on: the increasing incidence of retinal detachments

Mariam El-Abiary
Fatemah Shams
David Yorston
ResearchOpen Access01 Jun 2022
Eye

Volume: 37, P: 1320-1324
Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

Archived vials of cadaveric human growth hormone contain substantial levels of amyloid-β (Aβ) peptides and can seed Aβ plaques in susceptible mice, suggesting that this material could have transmitted Aβ pathology to humans.

Silvia A. Purro
Mark A. Farrow
John Collinge
Research13 Dec 2018
Nature

Volume: 564, P: 415-419
Erratum: The RA-MAP Consortium: a working model for academia–industry collaboration

Andrew P. Cope
Michael R. Barnes
James Butler
Amendments and Corrections24 Jan 2018
Nature Reviews Rheumatology

Volume: 14, P: 119
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Heribert Schunkert and colleagues report a meta-analysis of 14 genome-wide association studies of coronary disease (CAD) followed by replication in additional cohorts. They confirm 10 previously associated loci and identify 13 loci newly associated with CAD.

Heribert Schunkert
Inke R König
Nilesh J Samani
Research06 Mar 2011
Nature Genetics

Volume: 43, P: 333-338
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Gerard Schellenberg and colleagues report a genome-wide association study of late-onset Alzheimer's disease (LOAD), as part of the Alzheimer Disease Genetics Consortium. They identify common variants in MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 associated with LOAD.

Adam C Naj
Gyungah Jun
Gerard D Schellenberg
Research03 Apr 2011
Nature Genetics

Volume: 43, P: 436-441
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Adam Shlien, Peter Campbell, Uri Tabori and colleagues report genome and exome sequencing of biallelic mismatch repair deficiency cancer samples from 12 children, including 10 high-grade gliomas. The hypermutational signature of the malignant glioma samples was consistent with a driver role for observed mutations in DNA polymerases ɛ or δ.

Adam Shlien
Brittany B Campbell
Uri Tabori
Research02 Feb 2015
Nature Genetics

Volume: 47, P: 257-262
Book Reviews

Dr David F Marshall
Books & Arts01 Apr 1989
Heredity

Volume: 62, P: 279
Congenital cataract: The history, the nature and the practice

David Taylor
Research01 Jan 1998
Eye

Volume: 12, P: 9-36
Relationship between 233 colorectal cancer risk loci and survival in 1926 patients with advanced disease

Christopher Wills
Amy Houseman
Jeremy P. Cheadle
ResearchOpen Access22 Jun 2023
BJC Reports

Volume: 1, P: 1-5
Transformers for rapid detection of airway stenosis and stridor

James Anibal
Rebecca Doctor
Yael Bensoussan
ResearchOpen Access02 May 2025
Scientific Reports

Volume: 15, P: 1-10
Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus

Janet M Risk
Kathryn E Evans
John K Field
Research12 Sept 2002
Oncogene

Volume: 21, P: 6395-6402
Deep learning models for histologic grading of breast cancer and association with disease prognosis

Ronnachai Jaroensri
Ellery Wulczyn
Po-Hsuan Cameron Chen
ResearchOpen Access04 Oct 2022
npj Breast Cancer

Volume: 8, P: 1-12
New patterns of infecting organisms in late bleb-related endophthalmitis: A ten year review

Samra Waheed
David C Ritterband
Robert Ritch
Research01 Nov 1998
Eye

Volume: 12, P: 910-915
CITRINO: phase 1 dose escalation study of anti-LAG-3 antibody encelimab alone or in combination with anti-PD-1 dostarlimab in patients with advanced/metastatic solid tumours

J. Randolph Hecht
Jean-Marie Michot
Susanna Ulahannan
ResearchOpen Access27 Feb 2025
BJC Reports

Volume: 3, P: 1-11
Celebrate the scientific hierarchy

The validity of our scientific descriptions of reality does not hinge on their emergence from a more fundamental theory.

George Ellis
David Sloan
Comments & Opinion01 Nov 2017
Nature Physics

Volume: 13, P: 1034
Slowing ageing by design: the rise of NAD⁺ and sirtuin-activating compounds

Sirtuins are NAD⁺-dependent protein deacylases that can reverse various aspects of ageing in model organisms. Trials in non-human primates and humans indicate that sirtuin-activating compounds (STACs) and NAD⁺precursors are safe and effective in treating inflammatory and metabolic disorders, thereby holding great potential to treat various diseases and to extend lifespan in humans.

Michael S. Bonkowski
David A. Sinclair
Reviews24 Aug 2016
Nature Reviews Molecular Cell Biology

Volume: 17, P: 679-690
Region-specific gene expression profiling of early mouse mandible uncovered SATB2 as a key molecule for teeth patterning

Petra Nevoránková
Marie Šulcová
Marcela Buchtová
ResearchOpen Access06 Aug 2024
Scientific Reports

Volume: 14, P: 1-19
INTESTINAL PERFORATIONS SECONDARY TO MECHANICAL VENTILATION WITH NASAL PRONGS (NP) OR FACE MASK (FM)

Jeff Garland
David Nelson
Josef Neu
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 323
SCOT: a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer

José Robles-Zurita
Kathleen A. Boyd
James Paul
ResearchOpen Access13 Nov 2018
British Journal of Cancer

Volume: 119, P: 1332-1338
Targeted gene correction of α₁-antitrypsin deficiency in induced pluripotent stem cells

Kosuke Yusa
S. Tamir Rashid
Ludovic Vallier
Research12 Oct 2011
Nature

Volume: 478, P: 391-394
A vision for incorporating human mobility in the study of human–wildlife interactions

Wildlife are affected by human movement and static human infrastructure. In this Perspective, the authors propose a ‘dynamic human footprint’ that incorporates metrics accounting for time-varying human activities.

Diego Ellis-Soto
Ruth Y. Oliver
Walter Jetz
Reviews07 Aug 2023
Nature Ecology & Evolution

Volume: 7, P: 1362-1372
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.

Amritha Nair
Hsiang-Ching Chung
Thomas F Westbrook
Research26 Mar 2018
Nature Medicine

Volume: 24, P: 505-511
Cognitive behavioral therapy for fibromyalgia

Initially used in the treatment of mood disorders, this form of psychotherapy has been extended to other conditions such as chronic pain states. This Review evaluates the role of cognitive behavioral therapy, alone or in combination with other modalities, in the management of patients with fibromyalgia.

Robert Bennett
David Nelson
Reviews01 Aug 2006
Nature Clinical Practice Rheumatology

Volume: 2, P: 416-424
Artificial intelligence for modelling infectious disease epidemics

This Perspective considers the application to infectious disease modelling of AI systems that combine machine learning, computational statistics, information retrieval and data science.

Moritz U. G. Kraemer
Joseph L.-H. Tsui
Samir Bhatt
Reviews19 Feb 2025
Nature

Volume: 638, P: 623-635
Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Nicola Whiffin
Konrad J. Karczewski
James S. Ware
Amendments and CorrectionsOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Extensive, high-dimensional characterization of T cells in breast cancer reveals activated T_RM population and a gene signature associated with improved prognosis.

Peter Savas
Balaji Virassamy
Sherene Loi
Research25 Jun 2018
Nature Medicine

Volume: 24, P: 986-993
Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine

David Seal
John Hay
Malcolm Armstrong
Research01 Jul 1996
Eye

Volume: 10, P: 413-421
PI-3 kinase and IP3: partners in NT3-induced synaptic transmission

Neurotrophins are implicated in synaptic plasticity, but the signaling pathway was unknown. A new study shows that PI-3 kinase and IP3 are necessary and sufficient for NT3's actions.

David R. Kaplan
Ellis Cooper
News & Views01 Jan 2001
Nature Neuroscience

Volume: 4, P: 5-7
Forest biotechnology makes its position known

Steven Strauss
Wout Boerjan
Björn Sundberg
Comments & Opinion01 Dec 1999
Nature Biotechnology

Volume: 17, P: 1145
Mapping the field of cultural evolutionary theory and methods in archaeology using bibliometric methods

David N. Matzig
Clemens Schmid
Felix Riede
ResearchOpen Access30 May 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-17
A medium-chain fatty acid analogue prevents endotoxin liver injury in a murine model

Sarah Z. Wang
Thomas I. Hirsch
Mark Puder
ResearchOpen Access20 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4
Novel properties of the cyclin encoded by Human Herpesvirus 8 that facilitate exit from quiescence

Emma S Child
David J Mann
Research22 Jun 2001
Oncogene

Volume: 20, P: 3311-3322
A Bacillus thuringiensis δ-endotoxin induces programmed cell death in mosquito larvae

David Smouse
James Nishiura
Research01 Oct 1997
Cell Death & Differentiation

Volume: 4, P: 560-569
Multicenter investigation on the influence of climate in penile prosthesis infection

Martin S. Gross
Annah J. Vollstedt
Ricardo Munarriz
Research01 May 2019
International Journal of Impotence Research

Volume: 32, P: 387-392
The effect of age on phenotype of primary rhegmatogenous retinal detachment

Mariantonia Ferrara
Mo Al-Zubaidy
David Yorston
Research26 Apr 2022
Eye

Volume: 37, P: 1114-1122
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

David J Hunter
Peter Kraft
Stephen J Chanock
Research27 May 2007
Nature Genetics

Volume: 39, P: 870-874
Author Correction: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Xing Yi Woo
Jessica Giordano
Emilie Vinolo
Amendments and CorrectionsOpen Access19 Feb 2021
Nature Genetics

Volume: 53, P: 761
Practical implications of gene-expression-based assays for breast oncologists

Gene-expression profiling has led to the development of signatures designed to predict survival and treatment response in patients with breast cancer. In this Review, Prat et al. discuss the clinical utility of gene-expression-based assays and compare them with the performance of breast cancer biomarkers that are currently used as standard of care.

Aleix Prat
Matthew J. Ellis
Charles M. Perou
Reviews06 Dec 2011
Nature Reviews Clinical Oncology

Volume: 9, P: 48-57
Breeding structure of three snow pool Aedes mosquito species in northern Colorado

David F West
William C Black IV
Research01 Oct 1998
Heredity

Volume: 81, P: 371-380

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