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Showing 1–18 of 18 results
Advanced filters: Author: Daniel J. Christoffel Clear advanced filters

  • Existing feature visualisation methods are not well-suited for regression tasks. Here, authors introduce a method to learn the manifold topology related to deep neural network output and target labels and provide insightful visualisations of the high-dimensional features while preserving the local geometry.

    • Md Tauhidul Islam
    • Zixia Zhou
    • Lei Xing
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Dual catalysis is widely employed by natural metalloenzymes to functionalize challenging substrates. Now, this concept is applied to artificial metalloenzymes by designing a hydroaminase with two biotinylated gold cofactors enabling an unnatural σ,π-activation mechanism of terminal alkynes.

    • Fadri Christoffel
    • Nico V. Igareta
    • Thomas R. Ward
    Research
    Nature Catalysis
    Volume: 4, P: 643-653

  • Chronic social-defeat stress increases phasic firing of ventral tegmental area (VTA) neurons and increases the amount of BDNF in the nucleus accumbens (NAc). The authors show that increased activity of NAc-projecting VTA neurons is sufficient to increase the amount of BDNF in the NAc, an effect that depends on CRF signaling in the NAc.

    • Jessica J Walsh
    • Allyson K Friedman
    • Ming-Hu Han
    Research
    Nature Neuroscience
    Volume: 17, P: 27-29

  • Hedonic feeding occurs in the absence of metabolic need and plays a critical role in the excessive feeding that underlies obesity. The authors show that optogenetic manipulation of NAc inputs from the prefrontal cortex versus inputs from the anterior paraventricular nucleus of the thalamus has opposite effects on high fat intake.

    • Daniel J. Christoffel
    • Jessica J. Walsh
    • Robert C. Malenka
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Antipsychotic treatment in patients with schizophrenia often reduces hallucinations and delusions, but cognitive deficits that impair performance of everyday activities may persist or worsen. Our findings reveal a mechanism by which increased NF-κB activity leads to increased HDAC2 levels, impairing synaptic plasticity and memory during prolonged antipsychotic treatment.

    • Daisuke Ibi
    • Mario de la Fuente Revenga
    • Javier González-Maeso
    Research
    Nature Neuroscience
    Volume: 20, P: 1247-1259

  • A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.

    • Ana López-Saavedra
    • Daniel Gómez-Cabello
    • Pablo Huertas
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Repeated exposure to cocaine increases dendritic spine density on nucleus accumbens (NAc) neurons. Here the authors show that the small GTPase Rac1 is necessary and sufficient for cocaine-induced behavior and spine changes in NAc neurons, adding support for a causal role for structural plasticity in cocaine-induced behavior.

    • David M Dietz
    • Haosheng Sun
    • Eric J Nestler
    Research
    Nature Neuroscience
    Volume: 15, P: 891-896

  • Chronic stress and depression induce structural and functional plasticity; however, the mechanisms responsible for these alterations remain incompletely characterized. Here Scott J Russo and colleagues demonstrate that the Rac1 promoter is epigenetically modified, and its expression is reduced in the nucleus accumbens of mice after chronic defeat stress and in subjects with major depressive disorders. Reduced Rac1 expression is sufficient to induce depression-related behavior and stubby spine formation in mice.

    • Sam A Golden
    • Daniel J Christoffel
    • Scott J Russo
    Research
    Nature Medicine
    Volume: 19, P: 337-344

  • Chronic social stress has adverse behavioral consequences and can result in the development of depression in humans. Using a rodent social stress model, we report increased synaptic connectivity between the thalamus and striatum in susceptible mice that controls behavioral coping mechanisms relevant to depression.

    • Daniel J Christoffel
    • Sam A Golden
    • Scott J Russo
    Research
    Nature Neuroscience
    Volume: 18, P: 962-964

  • Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat paradigm and in previously resilient mice that have been subjected to repeated social-defeat stress, and this effect is projection-pathway specific.

    • Dipesh Chaudhury
    • Jessica J. Walsh
    • Ming-Hu Han
    Research
    Nature
    Volume: 493, P: 532-536

  • Here, the circuits underlying the motivational or rewarding component to aggression are deconstructed, showing that an inhibitory projection from the basal forebrain to the lateral habenula bi-directionally controls this aspect of aggression.

    • Sam A. Golden
    • Mitra Heshmati
    • Scott J. Russo
    Research
    Nature
    Volume: 534, P: 688-692