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Showing 1–7 of 7 results
Advanced filters: Author: David Andrijevic Clear advanced filters

  • Multi-omics profiling of the blood and heart of two human decedents receiving pig heart xenografts, including single-cell studies, reveals early immune responses and perioperative cardiac xenograft dysfunction in one of the two decedents, which may be due to mismatched heart size and/or insufficient immunosuppression.

    • Eloi Schmauch
    • Brian Piening
    • Brendan J. Keating
    Research
    Nature Medicine
    Volume: 30, P: 1448-1460

  • OrganEx—an extracorporeal pulsatile-perfusion system with cytoprotective perfusate for porcine whole-body settings—preserved tissue integrity, decreased cell death and restored selected molecular and cellular processes across multiple vital organs after 1 h of warm ischaemia in pigs.

    • David Andrijevic
    • Zvonimir Vrselja
    • Nenad Sestan
    Research
    Nature
    Volume: 608, P: 405-412

  • Studies in mice, humans and macaques show that retinoic acid signalling has an important role in the development of the prefrontal cortex (PFC) in primates and may also underlie the evolutionary diversification of the PFC.

    • Mikihito Shibata
    • Kartik Pattabiraman
    • Nenad Sestan
    Research
    Nature
    Volume: 598, P: 483-488

  • Emerging perfusion technologies restore circulation and mitigate cell damage post ischaemia and reperfusion, showing promise for resuscitation medicine and organ transplantation. This Review explores cellular injury mechanisms, machine perfusion approaches and perfusate modifications for organ and whole-body recovery following circulatory cessation.

    • David Andrijevic
    • Ana Spajic
    • Nenad Sestan
    Reviews
    Nature Reviews Bioengineering
    Volume: 3, P: 596-611

  • The brain is particularly susceptible to injury after ischaemia; however, emerging evidence suggests that, under certain conditions, it may show more resilience. Daniele et al. review the effects of ischaemia on the brain and efforts to study and protect the post-ischaemic brain.

    • Stefano G. Daniele
    • Georg Trummer
    • Nenad Sestan
    Reviews
    Nature Reviews Neuroscience
    Volume: 22, P: 553-572