Nature Search

A comparison of exercise interventions from bed rest studies for the prevention of musculoskeletal loss

Nagarjun N. Konda
Rama S. Karri
Rochelle M. Velho
ResearchOpen Access08 May 2019
npj Microgravity

Volume: 5, P: 1-11
Isotypic and allotypic variation of human class II histocompatibility antigen α-chain genes

Charles Auffray
James W. Lillie
Jack L. Strominger
Research22 Mar 1984
Nature

Volume: 308, P: 327-333
Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

David J. Kwiatkowski
Thomas P. Stossel
Helen L. Yin
Research02 Oct 1986
Nature

Volume: 323, P: 455-458
Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

Milica Momcilovic
Anthony Jones
David B. Shackelford
Amendments and Corrections03 Jan 2020
Nature

Volume: 577, P: E7
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a master metabolic regulator, suppresses viral replication.

Peter J. Mullen
Gustavo Garcia Jr
Heather R. Christofk
ResearchOpen Access25 Mar 2021
Nature Communications

Volume: 12, P: 1-10
A novel HLA class II molecule (DRα–sDQβ) created by mismatched isotype pairing

Vincent Lotteau
Luc Teyton
Dominique Charron
Research24 Sept 1987
Nature

Volume: 329, P: 339-341
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

A positron emission tomography imaging tracer is developed to image mitochondrial function in vivo, and application of this tracer to a mouse model of lung cancer identifies distinct functional mitochondrial heterogeneity between tumour cells.

Milica Momcilovic
Anthony Jones
David B. Shackelford
Research30 Oct 2019
Nature

Volume: 575, P: 380-384
Reply to: In vivo quantification of mitochondrial membrane potential

Milica Momcilovic
Orian Shirihai
David B. Shackelford
Research08 Jul 2020
Nature

Volume: 583, P: E19-E20
A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

David B. Weiner
Jing Liu
Mark I. Greene
Research18 May 1989
Nature

Volume: 339, P: 230-231
Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

Takaaki Yoshimasa
David R. Sibley
Marc G. Caron
Research07 May 1987
Nature

Volume: 327, P: 67-70
LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer

LKB1 tumour suppressor gene is frequently mutated in lung adenocarcinoma. Here the authors show that in genetically engineered mouse models of lung cancer Lkb1 restoration induces growth arrest and drives neoplastic cells toward a more differentiated and less proliferative alveolar type II cell-like state via C/EBP-mediated reprogramming.

Christopher W. Murray
Jennifer J. Brady
Monte M. Winslow
ResearchOpen Access28 Feb 2022
Nature Communications

Volume: 13, P: 1-19
Targeting LKB1 in cancer – exposing and exploiting vulnerabilities

M Momcilovic
D B Shackelford
ReviewsOpen Access21 Jul 2015
British Journal of Cancer

Volume: 113, P: 574-584
Spatial mapping of mitochondrial networks and bioenergetics in lung cancer

A study describing an approach that combines imaging and profiling techniques to structurally and functionally analyse lung cancer in vivo, revealing heterogeneous mitochondrial networks and an association between bioenergetic phenotypes and mitochondrial organization and function.

Mingqi Han
Eric A. Bushong
David B. Shackelford
ResearchOpen Access15 Mar 2023
Nature

Volume: 615, P: 712-719
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

C Algire
L Amrein
M Pollak
Research22 Nov 2010
Oncogene

Volume: 30, P: 1174-1182
Bioluminescent-based imaging and quantification of glucose uptake in vivo

A bioluminescent glucose-uptake probe enables accurate, real-time, non-invasive longitudinal imaging of d-glucose absorption both in vitro and in vivo.

Tamara Maric
Georgy Mikhaylov
Elena Goun
Research13 May 2019
Nature Methods

Volume: 16, P: 526-532
SUBSPECIALTY PLATFORM SESSION

David J Fisher
Abraham Rudolph
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 40-56
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell carcinoma that renders it sensitive to glycolysis inhibition.

Justin Goodwin
Michael L. Neugent
Jung-whan Kim
ResearchOpen Access26 May 2017
Nature Communications

Volume: 8, P: 1-16
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication

Viruses can reprogram glutamine metabolism of host cells to support bioenergetics demands of viral replication. Here the authors show that adenoviral infection leads to enhanced glutamine metabolism through virus-mediated activation of MYC, which is required for optimal progeny virion generation.

Minh Thai
Shivani K. Thaker
Heather R. Christofk
ResearchOpen Access12 Nov 2015
Nature Communications

Volume: 6, P: 1-9
Modular polymer platform as a novel approach to head and neck cancer therapy

Yazeed Alhiyari
Jundong Shao
Maie A. St. John
ResearchOpen Access04 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
A bibliometric analysis of the interdisciplinary field of cultural evolution

Mason Youngblood
David Lahti
ResearchOpen Access02 Oct 2018
Palgrave Communications

Volume: 4, P: 1-9
Comparative host–pathogen associations of Snake Fungal Disease in sympatric species of water snakes (Nerodia)

Stephen F. Harding
C. Guilherme Becker
David Rodriguez
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-12
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression

The human tumour suppressor LKB1 directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK is a key therapeutic target in patients with diabetes, and the connection between AMPK and several tumour suppressors suggests that therapeutic manipulation of this pathway using established diabetes drugs warrants investigation in patients with cancer.

David B. Shackelford
Reuben J. Shaw
Reviews01 Aug 2009
Nature Reviews Cancer

Volume: 9, P: 563-575
Kinase-driven metabolic signalling as a predictor of response to carboplatin–paclitaxel adjuvant treatment in advanced ovarian cancers

Maria Isabella Sereni
Elisa Baldelli
Mariaelena Pierobon
ResearchOpen Access29 Jun 2017
British Journal of Cancer

Volume: 117, P: 494-502
Ubiquitination capabilities in response to neocarzinostatin and H₂O₂ stress in cell lines from patients with ataxia-telangiectasia

Allen Taylor
Fu Shang
Yosef Shiloh
Research25 Jun 2002
Oncogene

Volume: 21, P: 4363-4373
Climate analogs can catalyze cross-regional dialogs for US specialty crop adaptation

Siddharth Chaudhary
Kirti Rajagopalan
Timothy B. Sulser
ResearchOpen Access08 Jun 2023
Scientific Reports

Volume: 13, P: 1-12
N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells

Yu-Chuan Chen
Marian S. Navarrete
Begoña Diaz
ResearchOpen Access20 Jul 2020
Scientific Reports

Volume: 10, P: 1-18
The role of the ubiquitin/proteasome system in cellular responses to radiation

William H McBride
Keisuke S Iwamoto
Frank Pajonk
Reviews28 Aug 2003
Oncogene

Volume: 22, P: 5755-5773

Search

A comparison of exercise interventions from bed rest studies for the prevention of musculoskeletal loss

Isotypic and allotypic variation of human class II histocompatibility antigen α-chain genes

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

A novel HLA class II molecule (DRα–sDQβ) created by mismatched isotype pairing

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

Reply to: In vivo quantification of mitochondrial membrane potential

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer

Targeting LKB1 in cancer – exposing and exploiting vulnerabilities

Spatial mapping of mitochondrial networks and bioenergetics in lung cancer

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

Bioluminescent-based imaging and quantification of glucose uptake in vivo

SUBSPECIALTY PLATFORM SESSION

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication

Modular polymer platform as a novel approach to head and neck cancer therapy

A bibliometric analysis of the interdisciplinary field of cultural evolution

Comparative host–pathogen associations of Snake Fungal Disease in sympatric species of water snakes (Nerodia)

The LKB1–AMPK pathway: metabolism and growth control in tumour suppression

Kinase-driven metabolic signalling as a predictor of response to carboplatin–paclitaxel adjuvant treatment in advanced ovarian cancers

Ubiquitination capabilities in response to neocarzinostatin and H₂O₂ stress in cell lines from patients with ataxia-telangiectasia

Climate analogs can catalyze cross-regional dialogs for US specialty crop adaptation

N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells

The role of the ubiquitin/proteasome system in cellular responses to radiation

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