Nature Search

Tumour vesicular micromachinery uncovered

Tumour-secreted microvesicles carry bioactive molecules that can be transferred to recipient cells, impacting tumour progression. A study now shows that ARF6 drives miRNA loading into tumour microvesicles through interaction with pre-miRNA–Exportin-5 complexes, thus shedding light on specific cargo packaging mechanisms.

Gonçalo Rodrigues
Haiying Zhang
David Lyden
News & Views24 Jun 2019
Nature Cell Biology

Volume: 21, P: 795-797
Small RNA changes en route to distinct cellular states of induced pluripotency

Somatic cell reprogramming can induce distinct pluripotent states. Here the authors perform time-resolved small RNA expression profiling during the reprogramming of mouse embryonic fibroblasts and observe that distinct miRNA milieus characterise alternate states of pluripotency.

Jennifer L. Clancy
Hardip R. Patel
Thomas Preiss
Research10 Dec 2014
Nature Communications

Volume: 5, P: 1-9
Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line

David M. Bedwell
Anisa Kaenjak
Eric J. Sorscher
Research01 Nov 1997
Nature Medicine

Volume: 3, P: 1280-1284
Collagen in the Perilemma of Insect Nerve

DAVID S. SMITH
V. B. WIGGLESWORTH
Research10 Jan 1959
Nature

Volume: 183, P: 127-128
Are groundbreaking science discoveries becoming harder to find?

Researchers are arguing over whether ‘disruptive’ or ‘novel’ science is waning – and how to remedy the problem.

David Matthews
News21 May 2025
Nature

Volume: 641, P: 836-839
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch

Anti-TNF CAR macrophages show anti-inflammatory efficacy in both acute and chronic inflammatory disease mouse models.

Qi Cao
Yiping Wang
David C. H. Harris
ResearchOpen Access07 May 2025
Nature Biomedical Engineering

Volume: 9, P: 1502-1516
Influence of cyclic AMP on intracellular pH regulation and chloride fluxes in barnacle muscle fibres

WALTER F. BORON
JOHN M. RUSSELL
ALBERT ROOS
Research30 Nov 1978
Nature

Volume: 276, P: 511-513
Detection of X-ray emission from a bright long-period radio transient

A long-period radio transient with coincident radio and X-ray emission and observational properties unlike any known Galactic object has been observed by the Australian Square Kilometre Array Pathfinder.

Ziteng Wang
Nanda Rea
Nithyanandan Thyagarajan
Research28 May 2025
Nature

Volume: 642, P: 583-586
Variable oxygen airglow on Venus as a probe of atmospheric dynamics

David Alien
David Crisp
Vikki Meadows
Research08 Oct 1992
Nature

Volume: 359, P: 516-519
Intermediate-range solvent templating and counterion behaviour at charged carbon nanotube surfaces

Neutron scattering on a model system of highly concentrated solutions of charged carbon nanotubes reveals a strong solvent ordering up to ∼40 Å around the charged nanoscale surface.

Camilla Di Mino
Thomas F. Headen
Christopher A. Howard
ResearchOpen Access21 Feb 2025
Nature Nanotechnology

Volume: 20, P: 639-645
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

The trafficking defect associated with the cystic fibrosis disease-linked allele of the CFTR chloride channel is alleviated by inhibitors of histone deacetylases, suggesting that altering the transcription of genes associated with protein misfolding can ameliorate disease.

Darren M Hutt
David Herman
William E Balch
Research06 Dec 2009
Nature Chemical Biology

Volume: 6, P: 25-33
Activation of the Neutrophil Bactericidal Activity for Nontypable Haemophilus influenzae by Tumor Necrosis Factor and Lymphotoxin

Anne-Marie Tan
Antonio Ferrante
Allan W Cripps
Research01 Feb 1995
Pediatric Research

Volume: 37, P: 155-159
Observations and theory of the solar semidiurnal tide in the mesosphere of Venus

Stephen B. Fels
J. T. Schofield
David Crisp
Research29 Nov 1984
Nature

Volume: 312, P: 431-434
Divergent reprogramming routes lead to alternative stem-cell states

The forced expression of key transcription factors can induce somatic cells to acquire pluripotency characteristics; here high levels of reprogramming factors are used to induce mouse embryonic fibroblasts to a stable alternative pluripotent state with low intercellular adhesion.

Peter D. Tonge
Andrew J. Corso
Andras Nagy
Research10 Dec 2014
Nature

Volume: 516, P: 192-197
Growing single crystals of two-dimensional covalent organic frameworks enabled by intermediate tracing study

Resolving single-crystal structures of two-dimensional covalent organic frameworks (2D COFs) is a great challenge. Here, the authors identify two different growth mechanisms of COFs, enabling the growth and structure determination of micron-sized 2D single-crystalline COFs.

Chengjun Kang
Kuiwei Yang
Dan Zhao
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-9
Rise and fall of Western diseases

Nutrition and hygiene during early childhood are important in determining the risk of the diseases which follow industrialization. We still know little about the processes involved.

David J. P. Barker
Comments & Opinion30 Mar 1989
Nature

Volume: 338, P: 371-372
Snow precipitation on Mars driven by cloud-induced night-time convection

The Martian atmosphere hosts water-ice clouds, but it is thought that any snow precipitation settles slowly, rather than in storms. Martian meteorology simulations suggest that localized convective snowstorms can occur on Mars during the night.

Aymeric Spiga
David P. Hinson
Franck Montmessin
Research21 Aug 2017
Nature Geoscience

Volume: 10, P: 652-657
Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

Patients with the Long QT Syndrome type 2 have abnormal cardiac electrical activity, which is diagnosed by an electrocardiogram (ECG) that shows a prolonged QT interval and a notched T wave. Here the authors uncover the origins of this signature ECG phenotype by using a multi-scale cardiac modelling.

Arash Sadrieh
Luke Domanski
Adam P Hill
Research25 Sept 2014
Nature Communications

Volume: 5, P: 1-11
Correction: Corrigendum: Genome-wide characterization of the routes to pluripotency

Samer M. I. Hussein
Mira C. Puri
Andras Nagy
Amendments and Corrections17 Jun 2015
Nature

Volume: 523, P: 626
Correction: Corrigendum: Divergent reprogramming routes lead to alternative stem-cell states

Peter D. Tonge
Andrew J. Corso
Andras Nagy
Amendments and Corrections17 Jun 2015
Nature

Volume: 523, P: 626
Highly accurate protein structure prediction with AlphaFold

AlphaFold predicts protein structures with an accuracy competitive with experimental structures in the majority of cases using a novel deep learning architecture.

John Jumper
Richard Evans
Demis Hassabis
ResearchOpen Access15 Jul 2021
Nature

Volume: 596, P: 583-589
Zinc Deficiency: Effect on Brain of the Suckling Rat

Harold H Sandstead
David D Gillespie
Robert N Brady
Research01 Feb 1972
Pediatric Research

Volume: 6, P: 119-125
Naturally-occurring Wolbachia infection in Drosophila simulans that does not cause cytoplasmic incompatibility

Ary A Hoffmann
David Clancy
Jacinta Duncan
Research01 Jan 1996
Heredity

Volume: 76, P: 1-8
Clinical targeting of HIV capsid protein with a long-acting small molecule

The small molecule GS-6207, which disrupts the function of the HIV capsid protein, shows potential as a long-acting therapeutic agent for the treatment and prevention of HIV infection.

John O. Link
Martin S. Rhee
Tomas Cihlar
Research01 Jul 2020
Nature

Volume: 584, P: 614-618
Genome-wide characterization of the routes to pluripotency

This study presents an extensive molecular characterization of the reprograming process by analysis of transcriptomic, epigenomic and proteomic data sets describing the routes to pluripotency; it finds distinct routes towards two stable pluripotent states characterized by distinct epigenetic events.

Samer M. I. Hussein
Mira C. Puri
Andras Nagy
Research10 Dec 2014
Nature

Volume: 516, P: 198-206
Publisher Correction: Martian dust storm impact on atmospheric H₂O and D/H observed by ExoMars Trace Gas Orbiter

Ann Carine Vandaele
Oleg Korablev
Maria Paz Zorzano
Amendments and Corrections17 Apr 2019
Nature

Volume: 569, P: E1
Highly accurate protein structure prediction for the human proteome

AlphaFold is used to predict the structures of almost all of the proteins in the human proteome—the availability of high-confidence predicted structures could enable new avenues of investigation from a structural perspective.

Kathryn Tunyasuvunakool
Jonas Adler
Demis Hassabis
ResearchOpen Access22 Jul 2021
Nature

Volume: 596, P: 590-596
An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator

Somatic cell reprogramming can induce distinct pluripotent states. Here the authors perform time-resolved whole-genome bisulfite sequencing during the reprogramming of mouse embryonic fibroblasts and report dynamic global DNA methylation changes.

Dong-Sung Lee
Jong-Yeon Shin
Jeong-Sun Seo
ResearchOpen Access10 Dec 2014
Nature Communications

Volume: 5, P: 1-10
Author Correction: Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

Evan Der
Hemant Suryawanshi
Fan Zhang
Amendments and Corrections11 Oct 2019
Nature Immunology

Volume: 20, P: 1556
Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

Arnon Arazi
Deepak A. Rao
Daniel H. Goldman
Amendments and Corrections13 Aug 2019
Nature Immunology

Volume: 20, P: 1404
Martian dust storm impact on atmospheric H₂O and D/H observed by ExoMars Trace Gas Orbiter

High-resolution measurements of Martian atmospheric dust, water and semiheavy water, obtained by the ExoMars Trace Gas Orbiter during a global dust storm on Mars, are reported.

Ann Carine Vandaele
Oleg Korablev
Maria Paz Zorzano
Research10 Apr 2019
Nature

Volume: 568, P: 521-525
INTESTINAL PERFORATIONS SECONDARY TO MECHANICAL VENTILATION WITH NASAL PRONGS (NP) OR FACE MASK (FM)

Jeff Garland
David Nelson
Josef Neu
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 323
CXCR3⁺ monocytes/macrophages are required for establishment of pulmonary metastases

Kiah L. Butler
Eleanor Clancy-Thompson
David W. Mullins
ResearchOpen Access30 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample

Including participants from 45 countries, Bago et al. find that the situational factors that affect moral reasoning are shared across countries, with diminished observed cultural variation.

Bence Bago
Marton Kovacs
Balazs Aczel
Research14 Apr 2022
Nature Human Behaviour

Volume: 6, P: 880-895
Delineation of mechanisms and regions of dosage imbalance in complex rearrangements of 1p36 leads to a putative gene for regulation of cranial suture closure

Marzena Gajecka
Wei Yu
Lisa G Shaffer
Research13 Oct 2004
European Journal of Human Genetics

Volume: 13, P: 139-149
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

Nephritis is a major cause of lupus morbidity. Putterman and colleagues use single-cell RNA sequencing on human renal and skin biopsies to describe the expression landscape associated with lupus nephritis.

Evan Der
Hemant Suryawanshi
Fan Zhang
Research20 May 2019
Nature Immunology

Volume: 20, P: 915-927
The immune cell landscape in kidneys of patients with lupus nephritis

Much about the kidney-resident immune populations is a black box. Hacohen and colleagues use single cell RNA sequencing of kidney, skin and urine from lupus nephritis patients to describe the transcriptional state of the immune cells present in each compartment.

Arnon Arazi
Deepak A. Rao
Daniel H. Goldman
Research17 Jun 2019
Nature Immunology

Volume: 20, P: 902-914
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

Garry Cutting and colleagues report a genome-wide association and linkage study for loci that affect lung disease severity in cystic fibrosis. They identify two loci that influence lung function in individuals with cystic fibrosis.

Fred A Wright
Lisa J Strug
Garry R Cutting
Research22 May 2011
Nature Genetics

Volume: 43, P: 539-546
Earthquake early warning in Aotearoa New Zealand: a survey of public perspectives to guide warning system development

Julia S. Becker
Sally H. Potter
David M. Johnston
ResearchOpen Access04 Nov 2020
Humanities and Social Sciences Communications

Volume: 7, P: 1-12
Publisher Correction: No detection of methane on Mars from early ExoMars Trace Gas Orbiter observations

Oleg Korablev
Ann Carine Vandaele
Maria Paz Zorzano
Amendments and Corrections17 Apr 2019
Nature

Volume: 569, P: E2
Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations

Simon Gollins
Nick West
Sandy Beare
ResearchOpen Access31 Aug 2017
British Journal of Cancer

Volume: 117, P: 1286-1294
Publisher Correction: Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample

Bence Bago
Marton Kovacs
Balazs Aczel
Amendments and Corrections06 Jun 2022
Nature Human Behaviour

Volume: 6, P: 897-898
No detection of methane on Mars from early ExoMars Trace Gas Orbiter observations

Highly sensitive measurements of the atmosphere of Mars with the ExoMars Trace Gas Orbiter do not detect any methane over a range of latitudes in both hemispheres, in contrast to previous local or remote detections.

Oleg Korablev
Ann Carine Vandaele
Maria Paz Zorzano
Research10 Apr 2019
Nature

Volume: 568, P: 517-520
The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints

David A Thompson
Glenn Belinsky
Karl Münger
Research18 Dec 1997
Oncogene

Volume: 15, P: 3025-3035
Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort

Michael S. Bloom
Sudhi Upadhyaya
Lynne M. Smith
ResearchOpen Access15 Feb 2025
Journal of Exposure Science & Environmental Epidemiology

P: 1-11
The SARS-CoV-2 viral load in COVID-19 patients is lower on face mask filters than on nasopharyngeal swabs

Agnieszka Smolinska
David S. Jessop
Marc P. van der Schee
ResearchOpen Access29 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

Matthew B. Yurgelun
Anu B. Chittenden
Brian M. Wolpin
Research02 Jul 2018
Genetics in Medicine

Volume: 21, P: 213-223
Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy

Gontu et al. conducted a longitudinal study in COVID patients in which they assessed the response trajectories of antibodies directed to the SARS-CoV-2 surface spike glycoprotein and in vitro SARS-CoV-2 live virus neutralizing titers. Their measurements demonstrate the presence of an optimum window for convalescent plasma donation as well as predictions of the most suitable donor type.

Abhinay Gontu
Sreenidhi Srinivasan
Vivek Kapur
ResearchOpen Access24 Feb 2021
Communications Biology

Volume: 4, P: 1-9
Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo

Jhon Rivera-Monroy
Lena Musiol
Fabio Vilardi
ResearchOpen Access21 Dec 2016
Scientific Reports

Volume: 6, P: 1-13
Quantification metrics for telangiectasia using optical coherence tomography

Jillian L. Cardinell
Joel M. Ramjist
Pearce Wilcox
ResearchOpen Access02 Feb 2022
Scientific Reports

Volume: 12, P: 1-10

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