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Multicellular rosettes are known to mediate complex cellular reorganization such as epithelial folding and branching during embryonal organogenesis. Here the authors show that rosette formation regulated by β-Catenin and FGFR2 mediate postnatal adrenal cortex zona glomerulosa morphogenesis.

Light-responsive polymers with polarization-dependent deformation are promising material to develop tunable devices usually limited by irreversible dynamic control. Here, the authors use controlled polarization of visible light to produce arbitrary deformations into amorphous composites containing azopolymer microdomains to unlock the next level of complex actuation in soft lightdriven robots.

Cognitive behavioral therapy (CBT) is increasingly recognized for its potential to improve antiretroviral therapy adherence among people living with HIV. Here the authors conduct a systematic review and meta-analysis, revealing that CBT significantly enhances adherence, especially in individuals with psychiatric comorbidities and in low- and middle-income countries, although effects on viral metrics remain unclear.

Traction force microscopy is an effective method of measuring forces between cells and their environment, but requires removing the cells to obtain a reference image. Here the authors use nanodrip printing of quantum dots into compliant substrates to provide a regular array of fiducial spots, removing the need for a reference image.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

The transient reactivation of ETV2 in adult human endothelial cells reprograms these cells to become adaptable vasculogenic endothelia that in three-dimensional matrices self-assemble into vascular networks that can transport blood and physiologically arborize organoids and decellularized tissues.

Nuclear calcium oscillations initiate plant–arbuscular mycorrhiza and nitrogen-fixing bacteria symbioses for nutrient acquisition, with a newly discovered autoactive CNGC15 mutant enhancing these partnerships, potentially improving crop nutrition and reducing inorganic fertilizer dependence.

There are limitations with current protein sensing methods. Here the authors report DigitISA, a digital immunosensor assay based on microchip electrophoretic separation and single-molecule detection that enables quantitation of protein biomarkers in a single, solution-phase step.

The mechanism responsible for the toughness of nacre, the hierarchical iridescent material in seashells, is still unknown. Espinosa and colleagues show that the waviness of its tablets leads to interfacial hardening, and ultimately to energy dissipation, when the material is stressed.

Pores and channels within complex porous structures, such as the soil or the human gut, influence fluid flow and thus bacterial colonization. Here, Scheidweiler et al. study bacterial colonization of a model complex porous structure and show how the interactions between fluid flow, microscale structure, chemotaxis, and gradients of a quorum-sensing signaling molecule control the heterogenous accumulation of bacterial biomass.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

A photonic computing platform using chaotic light for probabilistic arithmetic enables ultrafast, parallel processing. The system predicts classification and uncertainty simultaneously. The optical architecture allows efficient distribution evaluations at each output in a single time step.

Eighteen years after the development of the first polymer-based LED display, the technology has finally matured and polymer OLED televisions are just around the corner.

Inspired by fast running cheetahs, the authors present a class of small-scale soft electromagnetic robots able to reach ultra-high running speeds of 70 BL/s (body lengths per second) as well as the ability to swim, jump, steer and transport cargo.

A simple automated system to simultaneously measure growth rate and lag time of large numbers of bacteria permits the identification of subsets in a heterogenous population.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

A microfluidic intestine-on-a-chip that allows the control of physiologically relevant oxygen gradients, enables the extended coculture of living human intestinal epithelium with stable communities of aerobic and anaerobic human gut microbiota.

Foreign body response can result in failure of biomaterials in vivo. Solvent-free crystals containing anti-fibrotic drugs now show the potential for long-term inhibition of fibrosis on a number of implantable devices in rodents and non-human primates.

Immune cells are believed not to generate large traction forces during migration. Now, measurements of natural killer cells in dense tissue reveal bursts of large traction forces as they move through narrow pores.

SERS is a powerful analytical technique, but achieving reproducibility for continuous analysis a challenge. Here, the authors report a SERS substrate recycling method that enables direct analysis of complex samples without substrate contamination.

We use bimolecular homolytic substitution catalysis to sort an electrophilic radical and a nucleophilic radical across an unactivated alkene, accelerating access to pharmaceutically relevant C(sp³)-rich molecules and defining a mechanistic approach for alkene dialkylation.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector function.

The development of high-performance implantable soft electronics as diagnostic platforms is key to realizing improved health monitoring. Here, the authors design wireless, battery-free, implantable bioelectronics that interface with the osseosurface for chronic musculoskeletal system monitoring.

Gas vesicles are air-filled protein nanostructures naturally expressed by certain bacteria and archaea to achieve cellular buoyancy. Here the authors show that, under the stimulation of pulsed ultrasound, targeted gas vesicles and gas vesicles expressed in genetically modified bacteria and mammalian cells release nanobubbles that, collapsing, lead to controlled mechanical damage of the surrounding biological milieu, demonstrating that, under focused ultrasound actuation, gas vesicles have potential applications as therapeutic agents.

Treatment of supported ceria nanoparticles at high temperature in gasoline vehicle exhaust/steam results in their dispersion into atomically thin oxide domains with enhanced oxygen mobility and storage capacity.

KCNQ1 channels are active in heart, brain and gut. Functional loss causes epilepsy and sudden arrhythmic death. Here, authors describe a key activator drug binding site, explaining isoform and drug selectivity, and point the way for new drug design.

Concerns about energy and inflation, linked to a conservative trend in US politics, are beginning to eclipse the moral commitment to a clean and safe environment characteristic of the past decade. In the first of three articles on how this has happened and what may follow, David Dickson describes how the energy issue has become a major threat to US environmental movements.

An implantable bioartificial kidney with a cell-containing bioreactor could be used to treat end-stage renal disease. Here the authors demonstrate the feasibility of an implantable bioreactor by maintaining human cell viability and functionality after implantation in a xenograft model.

Microtubules respond to mechanical compression by deforming, becoming more stable, which results in CLASP2 recruitment to the distorted shaft—a process crucial for cell migration through confined spaces.

A model that predicts the force behaviour for solid/liquid-dielectric multilayer stacks independent of actuator design, and solely based on the material properties, can be used to develop actuators that provide a steady force output under constant-voltage operation.

Two populations of neurons with distinct anatomy and receptor expression that convey information from the spinal cord to the brain have different functional properties with respect to touch and pain.

Devices for droplet generation are at the heart of many microfluidic applications but difficult to tailor for specific cases. Lashkaripour et al. show how design customization can greatly be simplified by combining rapid prototyping with data-driven machine learning strategies.

A global multi-taxon extinction risk assessment of freshwater fauna for The IUCN Red List of Threatened Species finds one-quarter of species to be at high risk of extinction.