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Too exposed?

DAVID K. FELBECK
Research25 Jul 1991
Nature

Volume: 352, P: 289
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Similarities and differences in latitudinal adaptation of two Drosophila sibling species

JEAN R. DAVID
CHARLES BOCQUET
Research16 Oct 1975
Nature

Volume: 257, P: 588-590
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Human T-cell lymphotropic virus type-I antibodies in Falashas and other ethnic groups in Israel

Zvi Ben-Ishai
Martin Haas
Fred C. Jensen
Research20 Jun 1985
Nature

Volume: 315, P: 665-666
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

RAF kinases are essential for RAS protein signalling but how RAS binding regulates dimerization and activation of RAF has remained unclear. Here, the authors report cryoEM structures that provide mechanistic insights into the RAS-mediated monomer-to-dimer transition of full-length BRAF.

Juliana A. Martinez Fiesco
David E. Durrant
Ping Zhang
ResearchOpen Access25 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Genetical and maternal determinants of the activity and preening behaviour of Drosophila melanogaster reared in different environments

David A Hay
Research01 Jun 1972
Heredity

Volume: 28, P: 311-336
Spectroelectrochemical analysis of the mechanism of (photo)electrochemical hydrogen evolution at a catalytic interface

Understanding reaction mechanisms in heterogeneous (photo)electrochemical catalysts is key to improving solar-to-fuel conversion efficiencies. Here the authors compare the mechanism of hydrogen evolution on ruthenium oxide as an electrocatalyst and as part of a photocathode via an optical/electrochemical approach.

Ernest Pastor
Florian Le Formal
James R. Durrant
ResearchOpen Access24 Feb 2017
Nature Communications

Volume: 8, P: 1-7
Orientation dependent molecular electrostatics drives efficient charge generation in homojunction organic solar cells

Though single-material organic solar cells are attractive for next-generation photovoltaic technologies, designing new materials with ideal properties remains a challenge. Here, the authors report the use of orientation-dependent molecular electrostatics to realise efficient homojunction devices.

Yifan Dong
Vasileios C. Nikolis
Koen Vandewal
ResearchOpen Access15 Sept 2020
Nature Communications

Volume: 11, P: 1-9
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Design, synthesis, and application of a Protein A mimetic

Rongxiu Li
Victor Dowd
Christopher R. Lowe
Research01 Feb 1998
Nature Biotechnology

Volume: 16, P: 190-195
Diamond mirrors for high-power continuous-wave lasers

Mirrors that demonstrate 98% reflectivity and withstand 10 kilowatts of focused continuous-wave laser light are created by nanoscale fabrication of single-crystal diamond. The work finds applications in medicine, defence, industry, and communications.

Haig A. Atikian
Neil Sinclair
Marko Lončar
ResearchOpen Access11 May 2022
Nature Communications

Volume: 13, P: 1-8
Unravelling the effect of charge dynamics at the plasmonic metal/semiconductor interface for CO₂ photoreduction

Light-driven CO₂ reduction provides a way to limit greenhouse gas concentrations, but understanding how materials accomplish this transformation is challenging. Here, authors examine the reaction over plasmonic silver-titanium dioxide using time-resolved, in situ techniques to follow the mechanism.

Laura Collado
Anna Reynal
Víctor A. de la Peña O’Shea
ResearchOpen Access26 Nov 2018
Nature Communications

Volume: 9, P: 1-10
Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

While biologics have been successfully applied in TNF antagonist treatments, there are no clinically approved small molecules that target TNF. Here, the authors discover potent small molecule inhibitors of TNF, elucidate their molecular mechanism, and demonstrate TNF inhibition in vitro and in vivo.

James O’Connell
John Porter
Alastair Lawson
ResearchOpen Access19 Dec 2019
Nature Communications

Volume: 10, P: 1-12
Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice

The role of dietary fat vs sugar in the global obesity epidemic remains controversial. Using Nutritional Geometry methodology, the authors show that, in mice, both fats and sugars could lead to adverse metabolic outcomes, depending on the dietary context.

Jibran A. Wali
Duan Ni
Stephen J. Simpson
ResearchOpen Access21 Jul 2023
Nature Communications

Volume: 14, P: 1-12
341 EFFECTS OF AMILORIDE ON MYOCARDIAL CONTRACTILE FUNCTION IN IMMATURE (I) VERSUS ADULT (A) RABBITS

Michael Artman
David Crump
Robert J Boucek Jr.
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 167
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health

Simpson and colleagues systematically interrogate the influence of dietary carbohydrate type and quality on the obesogenic impact of protein-diluted diets in mice.

Jibran A. Wali
Annabelle J. Milner
Stephen J. Simpson
Research08 Jun 2021
Nature Metabolism

Volume: 3, P: 810-828
Linking in situ charge accumulation to electronic structure in doped SrTiO₃ reveals design principles for hydrogen-evolving photocatalysts

Understanding the origin of unprecedented solar-to-hydrogen efficiencies in doped SrTiO₃ has proved challenging. Linking in situ charge accumulation to electronic structure in this system now reveals design principles for hydrogen-evolving photocatalysts.

Benjamin Moss
Qian Wang
James R. Durrant
Research11 Jan 2021
Nature Materials

Volume: 20, P: 511-517
Reducing the efficiency–stability–cost gap of organic photovoltaics with highly efficient and stable small molecule acceptor ternary solar cells

Ternary organic blends using two non-fullerene acceptors are shown to improve the efficiency and stability of low-cost solar cells based on P3HT and of high-performance photovoltaic devices based on low-bandgap donor polymers.

Derya Baran
Raja Shahid Ashraf
Iain McCulloch
Research21 Nov 2016
Nature Materials

Volume: 16, P: 363-369
Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity

B cells are thought to divide asymmetrically to generate distinct lineages required for adaptive immunity. Hawkins et al. find that surprisingly, mice lacking components of a complex required for asymmetric cell division display normal responses to vaccination and viral infection.

Edwin D. Hawkins
Jane Oliaro
Sarah M. Russell
Research30 Apr 2013
Nature Communications

Volume: 4, P: 1-11
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Reconstruction of the X and Y haplotypes in the genetically improved Abbassa nile tilapia genome assembly

Graham Etherington
Adam Ciezarek
Wilfried Haerty
ResearchOpen Access08 May 2025
Scientific Reports

Volume: 15, P: 1-14
Manipulation of B-cell responses with histone deacetylase inhibitors

Histone deaceytelase inhibitors are used in the treatment of haematological malignancies but can also act as modulators of the immune system. Here, the authors show that histone deaceytelase inhibitors are capable of modulating B-cell functions leading to improved outcome in autoimmune conditions.

Michaela Waibel
Ailsa J. Christiansen
Edwin D. Hawkins
Research27 Apr 2015
Nature Communications

Volume: 6, P: 1-12
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Emerging fungal pathogen Ophidiomyces ophiodiicola in wild European snakes

Lydia H. V. Franklinos
Jeffrey M. Lorch
Becki Lawson
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-7
Sequence-based characterization of structural variation in the mouse genome

Binnaz Yalcin
Kim Wong
Jonathan Flint
Research14 Sept 2011
Nature

Volume: 477, P: 326-329
Acute appetite reduction associated with an increased frequency of eating in obese males

David P Speechly
Geoffrey G Rogers
Rochelle Buffenstein
Research11 Nov 1999
International Journal of Obesity

Volume: 23, P: 1151-1159
The genome sequence of the Violet Carpenter Bee, Xylocopa violacea (Linnaeus, 1785): a hymenopteran species undergoing range expansion

Will J. Nash
Angela Man
Wilfried Haerty
ResearchOpen Access16 Sept 2024
Heredity

Volume: 133, P: 381-387
Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection

Thomas Crellen
Fiona Allan
James A. Cotton
ResearchOpen Access16 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin

Qiang Dai
Jihua Liu
Ray M Lee
Research12 Apr 2004
Oncogene

Volume: 23, P: 3650-3658
Chromosome-scale genome assembly and de novo annotation of Alopecurus aequalis

Jonathan Wright
Kendall Baker
Dana MacGregor
ResearchOpen Access18 Dec 2024
Scientific Data

Volume: 11, P: 1-15
Targeting the Raf kinases in human cancer: the Raf dimer dilemma

David E Durrant
Deborah K Morrison
ReviewsOpen Access14 Dec 2017
British Journal of Cancer

Volume: 118, P: 3-8

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