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EchoNext, a deep learning model for electrocardiograms trained and validated in diverse health systems, successfully detects many forms of structural heart disease, supporting the potential of artificial intelligence to expand access to heart disease screening at scale.

Colloidal perovskite quantum dots hold promise for polaritonic devices with strong excitonic confinement. Here the authors report the observation of room-temperature cavity exciton-polariton condensation in a perovskite-based quantum dot solid, opening the door towards quantum and photonics applications.

Synthetic nanocages that can adapt the size and shape of their cavity in response to a given guest have potential applications in various areas, including chemical purification. Now a flexible, pseudo-cubic metal–organic cage has been developed that is able to dynamically expand its cavity from 46% to 154% of its initial volume by flipping its cage faces.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder.

The aryl hydrocarbon receptor regulates the expression of genes involved in many cell processes and its dysregulation has been implicated in different diseases. Here, the authors identify dietary monoterpenoid carvone as an atypical non-competitive antagonist of human aryl hydrocarbon receptor and demonstrate that it can protect against ultraviolet skin damage in female mice.

Hydrodynamic phonon transport occurs when phonons are able to drift over macroscopic distances, leading to the breakdown of Fourier’s law of heat conduction. Here, the authors predict that this regime occurs in suspended graphene at higher temperatures than bulk materials.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

Aguirre-Ghiso and colleagues report that bone-marrow-resident mesenchymal stem cells promote cancer dormancy through TGF-β family members.

Reduced dietary fibre together with mutations in the host mismatch repair machinery promote colon carcinogenesis by increasing inflammation, nitrate-fuelled growth of colibactin-producing Escherichia coli and colibactin-dependent genotoxic tissue damage.

In Drosophila, coherent slow-wave activity between sleep-promoting and locomotion-promoting neural networks provides a brain state structure that allows for quiescent behaviours.

Genome release of enteroviruses relies on exposure to acidic pH, but the mechanism of uncoating remains unclear. Here, Buchta et al. show that echovirus 18 loses one to three adjacent capsid-protein pentamers, resulting in an opening of more than 120 Å for genome release.

Spin and charge dynamics are inevitably linked, the study of the one often illuminating the other. Here, the authors study spin relaxation in ambipolar polymers and, backed by simulations, show how charge dynamics and wavefunction localization together set relaxation times up to room temperature.

High-resolution sequencing of longitudinal patient samples reveals subclonal mutational diversity in the stem cell compartment driving parallel evolution patterns in acute myeloid leukemia progression.

The mechanisms that underlie cognitive resilience during aging are poorly understood. Here, the authors describe a neurodegeneration checkpoint response mediated by the transcription factor REST that protects against the onset of Alzheimer’s disease.

Using the spin precession of Bose-condensed ⁸⁷Rb atoms as a clock, direct measurements are made of the time required for Rb atoms to quantum tunnel through a classically impenetrable barrier.

Pulmonary large cell neuroendocrine carcinoma is an aggressive subtype of lung cancer. Here, the authors identify distinct subtypes based on genomic alterations and transcriptomic alterations.

Pores and channels within complex porous structures, such as the soil or the human gut, influence fluid flow and thus bacterial colonization. Here, Scheidweiler et al. study bacterial colonization of a model complex porous structure and show how the interactions between fluid flow, microscale structure, chemotaxis, and gradients of a quorum-sensing signaling molecule control the heterogenous accumulation of bacterial biomass.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

In asthma, mucus plugging is an important cause of airflow obstruction, but it is not targeted by widely used bronchodilator and anti-inflammatory drugs. Here the authors show that reduction of disulfide bonds that hold mucin polymers together reverses asthma-like obstruction in mice.

Ali et al. show that, during heat shock, aggregation-prone orphan ribosomal proteins form nucleolar-associated condensates that are kept in a liquid-like and reusable state through Hsp70 and its co-chaperones.

Understanding and tuning the transport properties of colloidal particles near deformable and patchy interfaces have implications for biophysical processes and designs of nanofluidic devices. This work introduces a minimal model that hydrodynamically couples a colloidal particle to a fluctuating elastic mode under a periodic potential, revealing how soft boundaries and rapid nanoscale surface deformations leave measurable imprints on colloidal transport.

Immune receptors regulate immune responses and are key cancer immunotherapy targets. Here, the authors designed helical concave scaffolds to bind convex sites in immune receptors, creating high-affinity protein binders for TGFβRII, CTLA-4, and PD-L1. Co-crystal structures confirmed their therapeutic potential.

The 5-Cog paradigm, a culturally fair and non-literacy biased cognitive detection tool paired with a clinical decision support improved cognitive impairment diagnosis and management threefold in primary care patients with cognitive concerns.

Exome-sequencing analyses of a large cohort of patients with type 2 diabetes and control individuals without diabetes from five ancestries are used to identify gene-level associations of rare variants that are associated with type 2 diabetes.

Nearly integrable one-dimensional Bose gases are used to explain the behaviour of many-body quantum systems immediately after a rapid, high-energy quench, which shows two distinct timescales, one for hydrodynamization and the other for local prethermalization.

Using a graphene quantum dot creation and a wavefunction mapping technique, quantum scars are directly visualized for Dirac electrons with a scanning tunnelling microscope.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Photoelectron quantum-state tomography is demonstrated in helium and argon atoms upon the absorption of ultrashort, extreme ultraviolet light pulses. The purity and degree of entanglement of a mixed photoelectron and ion state are quantified following coherent two-photon ionization using an extreme ultraviolet pulse and two infrared pulses.

Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice and show that a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis is key for coronary artery development.

Dark-field momentum microscopy makes it possible to spatio-temporally and spatio-spectrally resolve the dark-exciton dynamics in a twisted transition metal dichalcogenide heterostructure.

Hole and particle-like quasiparticles of a Mott insulator can pair into excitonic bound states. Now, time-resolved measurements of Sr₂IrO₄ show signs of an excitonic fluid forming from a photo-excited population of quasiparticles.

Endothelial cells (EC) are known to contribute to haematopoietic stem cell (HSC) maintenance in the bone marrow (BM). Here the authors demonstrate that arterial ECs can be distinguished from sinusoidal ECs by podoplanin and Sca-1 expression, and that specifically arterial, but not sinusoidal ECs maintain HSCs by secreting SCF.

Superconductivity reported in metals driven away from equilibrium via optical pumping has been proposed to arise from nonlinear coupling between electrons and optically excited phonons. The authors use an exact approach to show that here, disorder, which disfavors superconductivity, emerges even though the system is translationally invariant.

Electrolyte engineering has proven an effective approach to enhance the performance of lithium metal batteries. Here the authors propose a strategy by using multiple solvents in weakly solvating electrolytes—dubbed as high-entropy electrolytes—to improve the ionic conductivity while maintaining electrochemical stability, leading to high-performance batteries.

Far-field mid-infrared spectroscopy reveals both the electroluminescence of hyperbolic phonon polaritons of hexagonal boron nitride excited by strongly biased graphene, and the associated radiative energy transfer through the material.

Ultrahigh electromechanical response is accomplished by inducing extreme structural instability from competing antiferroelectric and ferroelectric orders.