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By switching from a variable resistance to a tunable capacitance modulation principle using nanoscale lateral capacitors and leveraging substrate-side reflection, we achieve 100% amplitude modulation in graphene-based metamaterial terahertz modulators.

Its tunable energy bandgap makes bilayer graphene interesting both from a theoretical perspective and with a view to applications. But exactly how the bandgap is formed is still unclear. A scanning tunnelling spectroscopy study now finds that the microscopic picture of the gap is fundamentally different from what is expected from macroscopic measurements and currently developed theories.

Physical realizations of qubits are often vulnerable to leakage errors, where the system ends up outside the basis used to store quantum information. A leakage removal protocol can suppress the impact of leakage on quantum error-correcting codes.

Quantum dots in a nanowire are one possible approach to creating a solid-state quantum simulator. Here, the authors demonstrate the coupling of electronic states in a double quantum dot to form Andreev molecule states; a potential building block for longer chains suitable for quantum simulation.

A platform based on complementary metal–oxide–semiconductor (CMOS) technology operating with qubits close to 100 mK can generate static and dynamic signals for the control of many qubits.

A new approach is described for fabricating devices on each of the faces of the same gallium nitride semiconductor wafer, using the cation face for photonic devices and the anion face for electronic devices.

External driving of qubits can exploit their nonlinearity to generate different forms of interqubit interactions, broadening the capabilities of the platform.

As glaciers terminate into the ocean, mass is lost through frontal ablation where the ice meets the ocean. Here the authors estimate decadal frontal ablation from 2000 to 2020 of 1496 glaciers in the Northern Hemisphere, and find that frontal ablation makes up 79% of ice discharge to the ocean.

Extracellular vesicles (EVs), a diverse range of membrane-delimited particles, have multiple cellular functions and, when released by cancer cells, can promote tumour growth and metastatic dissemination. The authors of this Review describe advances in the development of EVs as biomarkers and cancer therapeutics, focusing on clinical translation of EVs into diagnostic and therapeutic clinical tools.

Cryo-electron microscopy and molecular dynamics simulations reveal how MFSD2A transports essential omega-3 fatty acids across the blood–brain and blood–retina barriers as lysolipids.

The atomic thickness of two-dimensional materials enables the realization of a small footprint transistor architecture for photoswitching logic computing in a single cell.

Filtering or gating relevant information into working memory has been attributed to the striatum. Here, the authors reveal neocortical filtering mechanisms, namely, rapid changes in oscillatory theta networks, that predict fast and flexible human behavior.

A wireless, minimally invasive emergency rescue device is developed for the active burst-release of stable particulate forms of peptide and hormone drugs into subcutaneous sites in mice.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The spectrally narrow photoluminescence lines occurring in transition metal dichalcogenides (TMD) heterostructures at low temperature have been attributed to interlayer excitons (IXs) localized by the moiré potential between the TMD layers. Here, the authors show that these lines are present even when the moiré potential is suppressed by inserting an hBN spacer between the TMD layers.

Recent experiments have shown the formation of ferroelectric domains in twisted van der Waals bilayers. Here, the authors report near-field infrared nano-imaging and nano-photocurrent measurements to investigate ferroelectricity in minimally twisted WSe₂ by visualizing the plasmonic and photo-thermoelectric response of an adjacent graphene monolayer.

Direct measurements of the conduction properties of strongly interacting ultracold fermions reveal the well-known drop of resistance associated with the onset of superfluidity.

In this single-arm phase 2 trial in patients with HR⁺HER2⁻ advanced breast cancer, treatment with the HER3-targeting antibody–drug conjugate paritumab deruxtecan led to encouraging objective response rates, and comprehensive exploratory analyses indicate potential biomarkers of response.

The proximity effect in semiconductor-superconductor nanowires is expected to generate an induced gap in the semiconductor. Here, the authors study the superconducting proximity effect in InSb nanowires with an Al/Pt shell, demonstrating control of the induced gap using electric and magnetic fields.

Here, the authors develop a spectroscopic technique whereby individual defects in an ultrathin hBN dielectric, placed in proximity to graphene, act as quantum dots. Dot-assisted tunneling is highly sensitive to the nearby graphene excitation spectrum, and allows probing of energy splitting in the excited Landau levels.

We report superconductivity, in a limited region of displacement field and density, in 5.0° twisted bilayer WSe₂ with a maximum critical temperature of 426 mK, establishing that moiré flat-band superconductivity extends beyond graphene structures.

While transmon is the most widely used superconducting qubit, the search for alternative qubit designs with improved characteristic is ongoing. Hyyppä et al. demonstrate a novel superconducting qubit, the unimon, that combines high anharmonicity and protection against low-frequency charge noise and flux noise.

The quantum critical behaviour of a two-impurity Kondo model variant is observed in a system of hybrid-semiconductor islands that could provide a scalable platform for solid-state quantum simulation

Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.

A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction of overall immune activation early during treatment. The patient had no definitive evidence of recurrence at 17 months after treatment.

LaccID, an engineered laccase, enables hydrogen-peroxide-free proximity labeling and electron microscopy (EM) in mammalian cells. Notably, LaccID is selectively active at the cell surface, enabling the mapping of the dynamic T cell–tumor surfaceome and its use as a genetically encodable EM tag, expanding the toolkit for cell-based imaging and proteomics.

A single electron spin in silicon is dressed by a microwave field to create a new qubit with tangible advantages for quantum computation and nanoscale research.

Electron-electron interactions in many-body systems may manifest themselves through the fractional quantum Hall effect. Here, the authors perform transport measurements in bilayer graphene, and observe particle-hole symmetric fractional quantum Hall states in theN=2 Landau level.

The presence of various noises in the qubit environment is a major limitation on qubit coherence time. Here, the authors demonstrate the use a closed-loop feedback to stabilize frequency noise in a flux-tunable superconducting qubit and suggest this as a scalable approach applicable to other types of noise.

In Vibrio cholerae, a type IVa pilus (T4aP) binds to exogenous DNA, and threads this DNA through the outer membrane secretin, PilQ. Here authors present the cryoEM structure of PilQ from native V. cholerae cells and design a series of mutants to reversibly regulate VcPilQ gate dynamics.

Using a peptide toxin and small vanilloid agonists as pharmacological probes, high-resolution electron cryo-microscopy structures of rat TRPV1–ligand complexes are solved; these structures highlight conformational differences between TRP and voltage-gated ion channels in their active states, and suggest a dual gating mechanism that may account for the ability of members of the TRP channel superfamily to integrate diverse physiological signals.

The full-fledged development of qudits in superconducting circuits is hindered by limited interaction toolkit and stringent requirements on frequencies and anharmonicities. Here, the authors propose and demonstrate an alternative scheme to perform multi-qudit gates in transmon-based devices, which is based on Raman-assisted two-photon interactions.

Individual electrons trapped on the surface of solid neon can operate as charge qubits with very long coherence times.

Using RFdiffusion, a general method for targeting intrinsically disordered proteins and regions for protein design has been developed.

Operating donor-based quantum computers in silicon is hindered by the dependence of inter-qubit coupling on the precise donor position. Here, the authors show controlled rotation operation on exchange-coupled electron spins in the weak-exchange regime, loosening the requirements on positioning precision.

Three tunable quantum Hall broken-symmetry states in charge-neutral graphene are identified by visualizing their lattice-scale order with scanning tunnelling microscopy and spectroscopy.

SLC35B1, initially thought to be a nucleotide sugar transporter, is an essential ATP/ADP exchanger that imports ATP into the endoplasmic reticulum through a unique stepwise translocation mechanism.

Isotope engineering of silicon carbide leads to control of nuclear spins associated with single divacancy centres and extended electron spin coherence.

The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi₂Te₄, and has implications for quantum chromodynamics, cosmology and string theory.

III–V semiconductors are promising platform for qubits, but strong coupling to lattice phonons enhances decoherence of qubit states that have a charge dipole. Here, the authors show that a microwave analogue to the Raman effect can lead to rapid dephasing of qubits based on GaAs double quantum dots.

In this study, the authors assess the global response to the toxic aldehyde glyoxal (GO) in Pseudomonas aeruginosa, suggesting that GO controls quorum sensing during infection through a mechanism involving a novel protein, ArqI.

Strontium titanate two-dimensional electron gas channels that have a thin hafnium oxide barrier layer between the channel and an ionic liquid gate can have ballistic constrictions and clean normal-state conductance quantization.