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As glaciers terminate into the ocean, mass is lost through frontal ablation where the ice meets the ocean. Here the authors estimate decadal frontal ablation from 2000 to 2020 of 1496 glaciers in the Northern Hemisphere, and find that frontal ablation makes up 79% of ice discharge to the ocean.

The SIT1-ACE2 complex transports the amino acid proline and is the receptor of SARS-CoV-2. Here, the authors identify specific sequence requirements for proline transport and explain for how a missense mutation causes iminoglycinuria.

By utilizing the van der Waals electron acceptor α-RuCl₃, this study establishes a p-type connection with WSe₂, facilitating a high hole mobility of 80,000 cm² V^–1 s^–1 for investigating quantum transport properties in a magnetic field of over 30 T.

The spectrally narrow photoluminescence lines occurring in transition metal dichalcogenides (TMD) heterostructures at low temperature have been attributed to interlayer excitons (IXs) localized by the moiré potential between the TMD layers. Here, the authors show that these lines are present even when the moiré potential is suppressed by inserting an hBN spacer between the TMD layers.

Cryo-electron microscopy and molecular dynamics simulations reveal how MFSD2A transports essential omega-3 fatty acids across the blood–brain and blood–retina barriers as lysolipids.

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

Physical realizations of qubits are often vulnerable to leakage errors, where the system ends up outside the basis used to store quantum information. A leakage removal protocol can suppress the impact of leakage on quantum error-correcting codes.

The atomic thickness of two-dimensional materials enables the realization of a small footprint transistor architecture for photoswitching logic computing in a single cell.

Sivanandan, Leitmann, and colleagues present the CellPaint-POSH platform, which combines pooled CRISPR screening with Cell Painting. Using self-supervised deep learning on cell images, the method enables discovery of gene function and biological networks.

Type IV pili (T4P) enable bacteria to sense, move, and adhere to surfaces. Here, the authors solve the structure of the T4P machine in Pseudomonas aeruginosa, revealing the localization and regulatory role of its tip adhesin, PilY1.

A Kitaev chain formed by two quantum dots coupled via a superconductor support the so-called poor man’s Majorana bound states. Here, the authors form a minimal Kitaev chain using Yu-Shiba-Rusinov states and show that the resulting bound states are more robust than in the case of unproximitized quantum dots.

Filtering or gating relevant information into working memory has been attributed to the striatum. Here, the authors reveal neocortical filtering mechanisms, namely, rapid changes in oscillatory theta networks, that predict fast and flexible human behavior.

Substitutionally doped two-dimensional diselenides can be used to make p-type field-effect transistors with reduced contact resistance and good electrostatic control by varying the thickness of the channel and contact regions.

External driving of qubits can exploit their nonlinearity to generate different forms of interqubit interactions, broadening the capabilities of the platform.

Direct measurements of the conduction properties of strongly interacting ultracold fermions reveal the well-known drop of resistance associated with the onset of superfluidity.

Recent experiments have shown the formation of ferroelectric domains in twisted van der Waals bilayers. Here, the authors report near-field infrared nano-imaging and nano-photocurrent measurements to investigate ferroelectricity in minimally twisted WSe₂ by visualizing the plasmonic and photo-thermoelectric response of an adjacent graphene monolayer.

Here, the authors develop a spectroscopic technique whereby individual defects in an ultrathin hBN dielectric, placed in proximity to graphene, act as quantum dots. Dot-assisted tunneling is highly sensitive to the nearby graphene excitation spectrum, and allows probing of energy splitting in the excited Landau levels.

Interactions between qubits and defect-related two-level systems in superconducting qubit devices are a major source of noise fluctuations that hinder error-mitigation performance. Here, the authors experimentally show that modulating this interaction can reduce noise fluctuation and improve error mitigation performance.

In analogy with quantum Hall systems, it may be possible to find non-abelian anyons in the higher bands of Chern insulators. Now, the phase diagram of the second moiré band of twisted MoTe₂ is explored, laying the groundwork for such investigations.

A new approach is described for fabricating devices on each of the faces of the same gallium nitride semiconductor wafer, using the cation face for photonic devices and the anion face for electronic devices.

The proximity effect in semiconductor-superconductor nanowires is expected to generate an induced gap in the semiconductor. Here, the authors study the superconducting proximity effect in InSb nanowires with an Al/Pt shell, demonstrating control of the induced gap using electric and magnetic fields.

A single electron spin in silicon is dressed by a microwave field to create a new qubit with tangible advantages for quantum computation and nanoscale research.

Electron-electron interactions in many-body systems may manifest themselves through the fractional quantum Hall effect. Here, the authors perform transport measurements in bilayer graphene, and observe particle-hole symmetric fractional quantum Hall states in theN=2 Landau level.

While transmon is the most widely used superconducting qubit, the search for alternative qubit designs with improved characteristic is ongoing. Hyyppä et al. demonstrate a novel superconducting qubit, the unimon, that combines high anharmonicity and protection against low-frequency charge noise and flux noise.

Cardiac fibrosis arises from persistent myofibroblast activity. This study reveals how chromatin factors control scar-forming cells in the heart and shows that inhibiting KAT5 can reduce harmful cardiac fibrosis.

Trapping electrons on a superfluid helium surface provides access to collective quantum phenomena and a platform for circuit quantum electrodynamics (cQED). Here, the authors demonstrate precision spatial and frequency engineering of plasmonic modes in a hybrid electron-on-helium system, opening the door towards integration of plasmon physics within future cQED-like devices.

The quantum critical behaviour of a two-impurity Kondo model variant is observed in a system of hybrid-semiconductor islands that could provide a scalable platform for solid-state quantum simulation

Using a peptide toxin and small vanilloid agonists as pharmacological probes, high-resolution electron cryo-microscopy structures of rat TRPV1–ligand complexes are solved; these structures highlight conformational differences between TRP and voltage-gated ion channels in their active states, and suggest a dual gating mechanism that may account for the ability of members of the TRP channel superfamily to integrate diverse physiological signals.

A van der Waals heterostructure made from atomic layers of ferroelectric CuCrP₂S₆ and ferromagnetic Fe₃GeTe₂ can offer reversible, non-volatile ferroelectric control of two-dimensional magnetism.

III–V semiconductors are promising platform for qubits, but strong coupling to lattice phonons enhances decoherence of qubit states that have a charge dipole. Here, the authors show that a microwave analogue to the Raman effect can lead to rapid dephasing of qubits based on GaAs double quantum dots.

A cavity-array microscope is realized using intra-cavity lenses to create a two-dimensional array of over 40 modes, each coupled to a single atom in free-space.

The presence of various noises in the qubit environment is a major limitation on qubit coherence time. Here, the authors demonstrate the use a closed-loop feedback to stabilize frequency noise in a flux-tunable superconducting qubit and suggest this as a scalable approach applicable to other types of noise.

Single cell transcriptomics and chromatin accessibility uncover the gene networks underlying planarian cell type differentiation, revealing insights into the combinatorial logic of planarian cell fate specification.

In Vibrio cholerae, a type IVa pilus (T4aP) binds to exogenous DNA, and threads this DNA through the outer membrane secretin, PilQ. Here authors present the cryoEM structure of PilQ from native V. cholerae cells and design a series of mutants to reversibly regulate VcPilQ gate dynamics.

A three-site Kitaev chain, constructed from three semiconducting quantum dots coupled by superconducting segments in a hybrid InSb/Al nanowire, shows enhanced robustness of edge zero-energy modes against variations in the coupling strengths or electrochemical potentials compared with a chain containing only two quantum dots.

The authors demonstrate a nanoscale particle-exchange heat engine using a diradical molecule coupled to superconducting electrodes. By driving a phase transition into the Yu-Shiba-Rusinov regime, they achieve a fivefold boost in thermoelectric power, enabling advances in cryogenic heat recovery and quantum cooling.

Understanding of the immune microenvironment in pediatric acute T cell lymphoblastic leukemia is limited. By analyzing single-cell transcriptome, surface protein expression and immune repertoire data, the authors here identify non-malignant CD4^-CD8^- TCRαβ T cells that are present in a subset of patients with Rap1 signaling in leukemia cells and are associated with adverse clinical outcome in patients with low minimal residual disease.

Individual electrons trapped on the surface of solid neon can operate as charge qubits with very long coherence times.

Operating donor-based quantum computers in silicon is hindered by the dependence of inter-qubit coupling on the precise donor position. Here, the authors show controlled rotation operation on exchange-coupled electron spins in the weak-exchange regime, loosening the requirements on positioning precision.

Three tunable quantum Hall broken-symmetry states in charge-neutral graphene are identified by visualizing their lattice-scale order with scanning tunnelling microscopy and spectroscopy.

Isotope engineering of silicon carbide leads to control of nuclear spins associated with single divacancy centres and extended electron spin coherence.

The full-fledged development of qudits in superconducting circuits is hindered by limited interaction toolkit and stringent requirements on frequencies and anharmonicities. Here, the authors propose and demonstrate an alternative scheme to perform multi-qudit gates in transmon-based devices, which is based on Raman-assisted two-photon interactions.

Strontium titanate two-dimensional electron gas channels that have a thin hafnium oxide barrier layer between the channel and an ionic liquid gate can have ballistic constrictions and clean normal-state conductance quantization.

An n-type semiconducting polymer is used to realize an organic electrochemical transistor working as a glucose sensor and an all-polymer enzymatic biofuel cell able to power the sensor itself.

A novel reporter captured spatial temporal dynamics of effector-triggered-immunity (ETI)-induced systemic immunity, revealing that signal propagation and establishment in systemic acquired resistance depend on jasmonates. Furthermore, ETI initiates jasmonate-dependent systemic induced surface electrical potentials.

An array of superconducting nanocircuits has been designed that provides built-in protection from environmental noises. Such ‘topologically protected’ qubits could lead the way to a scalable architecture for practical quantum computation.