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Showing 51–100 of 144 results

Advanced filters: Author: David J Durand Clear advanced filters

RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells

Pluripotency is coordinated at multiple levels of gene expression. Here the authors show that ribosome biogenesis is tightly regulated in embryonic stem cells (ESC) to control the translation of transcription and chromatin factors and dictate ESC fate.

Sébastien Durand
Marion Bruelle
Mathieu Gabut
ResearchOpen Access23 Jan 2023
Nature Communications

Volume: 14, P: 1-17
Common nonsynonymous variants in PCSK1 confer risk of obesity

Philippe Froguel and colleagues report that common nonsynonymous variants in PCSK1, encoding a prohormone convertase, confer risk of obesity in individuals of European ancestry.

Michael Benzinou
John W M Creemers
Philippe Froguel
Research06 Jul 2008
Nature Genetics

Volume: 40, P: 943-945
The long precursory phase of most large interplate earthquakes

Foreshocks precede some—but not all—earthquakes. Analysis of all earthquakes larger than magnitude 6.5 that occurred between 1999 and 2011 shows that earthquakes at plate boundaries are often preceded by increasing foreshock activity in the days leading up to the quake, whereas earthquakes in plate interiors often are not.

Michel Bouchon
Virginie Durand
Jean Schmittbuhl
Research24 Mar 2013
Nature Geoscience

Volume: 6, P: 299-302
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

Philippe Froguel and colleauges present a genome-wide association study for early-onset and morbid adult obesity, reporting three new genetic associations to obesity.

David Meyre
Jérôme Delplanque
Philippe Froguel
Research18 Jan 2009
Nature Genetics

Volume: 41, P: 157-159
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

A variant of the OAS1 gene, which encodes an enzyme that is critical for the innate immune response to viral infections, is associated with decreased risk of death in patients with COVID-19.

Sirui Zhou
Guillaume Butler-Laporte
J. Brent Richards
Research25 Feb 2021
Nature Medicine

Volume: 27, P: 659-667
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

JNJ-1802—a highly potent dengue virus inhibitor—blocks the NS3–NS4B interaction within the viral replication complex, and is highly effective against viral infection with DENV-1 or DENV-2 in non-human primates.

Olivia Goethals
Suzanne J. F. Kaptein
Marnix Van Loock
ResearchOpen Access15 Mar 2023
Nature

Volume: 615, P: 678-686
New screening approach for Alzheimer’s disease risk assessment from urine lipid peroxidation compounds

Carmen Peña-Bautista
Claire Vigor
Consuelo Cháfer-Pericás
ResearchOpen Access02 Oct 2019
Scientific Reports

Volume: 9, P: 1-8
The acute promyelocytic leukemia PML-RARα protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice

Gregory David
Benoit Terris
Anne Dejean
Research03 Apr 1997
Oncogene

Volume: 14, P: 1547-1554
SUBSPECIALTY PLATFORM SESSION

David J Fisher
Abraham Rudolph
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 40-56
A data citation roadmap for scholarly data repositories

Martin Fenner
Mercè Crosas
Tim Clark
ResearchOpen Access10 Apr 2019
Scientific Data

Volume: 6, P: 1-9
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

Carreras-Sureda et al. uncover a non-canonical role for IRE1α as a scaffold that stabilizes InsP₃Rs at MAMs to control calcium uptake, fine-tunes ER–mitochondrial communication and regulates energy metabolism via AMPK.

Amado Carreras-Sureda
Fabián Jaña
Claudio Hetz
Research20 May 2019
Nature Cell Biology

Volume: 21, P: 755-767
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

In a large multicentric study of patients with advanced NSCLC undergoing anti-PD-1 therapy, the relative abundance of intestinal Akkermansia spp. was shown to associate with changes in the gut microbiome ecosystem and clinical outcomes.

Lisa Derosa
Bertrand Routy
Benjamin Besse
Research03 Feb 2022
Nature Medicine

Volume: 28, P: 315-324
The promise of discovering population-specific disease-associated genes in South Asia

Kumarasamy Thangaraj, David Reich and colleagues identify 81 South Asian groups descended from extreme founder events, including 14 with a census size of over 1 million people, thus providing an opportunity to test for and decrease the burden of recessive genetic diseases in these populations.

Nathan Nakatsuka
Priya Moorjani
Kumarasamy Thangaraj
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1403-1407
The genome sequence of the Violet Carpenter Bee, Xylocopa violacea (Linnaeus, 1785): a hymenopteran species undergoing range expansion

Will J. Nash
Angela Man
Wilfried Haerty
ResearchOpen Access16 Sept 2024
Heredity

Volume: 133, P: 381-387
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
220 HYPOTENSIVE AUTOREGULATION OF CEREBRAL BLOOD FLOW DURING HYPOXIA

Richard J Traystman
David A Wilson
Mark C Rogers
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 147
218 VALIDATION OF THE NEAR INFRARED SPECTROPHOTOMETRY METHODOLOGY FOR MEASURING CEREBRAL BLOOD VOLUME CHANGES

Judith Stiff
David A Wilson
Mark C Rogers
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 147
Avian brains and a new understanding of vertebrate brain evolution

Erich D. Jarvis
Onur Güntürkün
Ann B. Butler
Reviews01 Feb 2005
Nature Reviews Neuroscience

Volume: 6, P: 151-159
Use of Agrobacterium rhizogenes to Create Chimeric Apple Trees Through Genetic Grafting

Claude Lambert
David Tepfer
Research01 Jan 1991
Bio/Technology

Volume: 9, P: 80-83
The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity

The undifferentiated Gonium pectorale represents the initial transition to multicellularity. Here, Bradley Olson, Erik Hanschen and colleagues describe the genome of Gonium pectorale, demonstrating that co-option of the retinoblastoma cell cycle regulatory pathway was a key genetic change in the evolution of multicellularity.

Erik R. Hanschen
Tara N. Marriage
Bradley J. S. C. Olson
ResearchOpen Access22 Apr 2016
Nature Communications

Volume: 7, P: 1-10
Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors

Ganuza et al. report that foetal liver haematopoietic stem cells (HSCs) are largely biased to differentiation rather than self-renewal, resulting in a modest expansion of the HSC pool with contribution to adult haematopoiesis.

Miguel Ganuza
Trent Hall
Shannon McKinney-Freeman
Research06 Oct 2022
Nature Cell Biology

Volume: 24, P: 1475-1486
Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

Weiping Zou
Véronique Machelon
Tyler J. Curiel
Research01 Dec 2001
Nature Medicine

Volume: 7, P: 1339-1346
Improvement of Ornamental Characters and Fragrance Production in Lemon-scented Geranium Through Genetic Transformation by Agrobacterium rhizogenes

Alessandro Pellegrineschi
Jain-Pierre Damon
David Tapfer
Research01 Jan 1994
Bio/Technology

Volume: 12, P: 64-68
A comparative approach to topical cyclosporine therapy

David L Williams
Research01 Jul 1997
Eye

Volume: 11, P: 453-464
The Role of β-Adrenoreceptor Stimulation and Contractile State in the Preterm Lamb's Response to Altered Ductus Arteriosus Patency

Ronald I Clyman
David Teitel
Francoise Mauray
Research01 Mar 1988
Pediatric Research

Volume: 23, P: 316-322
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development

Henninger et al. analyse the early clonal events that underlie haematopoiesis and establish the number of stem cell clones that arise from the ventral dorsal aorta to maintain lifelong blood production.

Jonathan Henninger
Buyung Santoso
Leonard Zon
Research21 Nov 2016
Nature Cell Biology

Volume: 19, P: 17-27
Effects of Birth-Related Events on Blood Flow Distribution

Harriet S Iwamoto
David Teitel
Abraham M Rudolph
Research01 Dec 1987
Pediatric Research

Volume: 22, P: 634-640
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
A DIAGNOSTIC APPROACH TO CHILDREN WITH SUSPECTED OBSTRUCTIVE SLEEP APNEA (OSA)

Robert T Brouillette
Donna Hanson
Carl E Hunt
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 228
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.

Carla Eller
Laura Heydmann
Thomas F. Baumert
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-17
Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

Amado Carreras-Sureda
Fabián Jaña
Claudio Hetz
Amendments and Corrections14 Jun 2019
Nature Cell Biology

Volume: 21, P: 913
LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake

David T. Wong
Frank P. Bymaster
David W. Robertson
Research01 Jan 1993
Neuropsychopharmacology

Volume: 8, P: 23-33
An integrated software system for analyzing ChIP-chip and ChIP-seq data

Analyzing the massive and heterogenous datasets from genome-wide chromatin immunoprecipitation (ChIP) datasets presents several computational and statistical challenges. Ji et al. present a software suite that integrates all steps in ChIP-chip and ChIP-seq data analyses and illustrate the use of these tools by comparing the ability of the two platforms to identify transcription factor binding sites.

Hongkai Ji
Hui Jiang
Wing H Wong
Research02 Nov 2008
Nature Biotechnology

Volume: 26, P: 1293-1300
A Pilot Study of Early Non-Tidal vs Tidal Ventilation in Premature Infants.† 990

Sherry E Courtney
David J Durand
Craig T Shoemaker
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 171
Growth-Promoting Actions of Parathyroid Hormone, Adrenocorticotrophic Hormone, and Thyroid-Stimulating Hormone: In Vitro Studies in Normal and Pygmy T-Lymphoblast Cell Lines

Mitchell E Geffner
Noelle Bersch
David W Golde
Research01 Apr 1995
Pediatric Research

Volume: 37, P: 507-511
Pulmonary Function and Electrolyte Balance Following Spironolactone Treatment in Preterm Infants With Chronic Lung Disease: A Double-Blind, Placebo-Controlled, Randomized Trial

David J Hoffman
Jeffrey S Gerdes
Soraya Abbasi
Research26 Jun 2000
Journal of Perinatology

Volume: 20, P: 41-45
Eight glacial cycles from an Antarctic ice core

Laurent Augustin
Carlo Barbante
Mario Zucchelli
Research10 Jun 2004
Nature

Volume: 429, P: 623-628
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

Rob Sladek and colleagues identify a common variant near the insulin receptor substrate 1 gene (IRS1) associated with type 2 diabetes, insulin resistance, hyperinsulinemia and impaired insulin signaling. This is the first confirmed diabetes risk locus associated with insulin resistance.

Johan Rung
Stéphane Cauchi
Robert Sladek
Research06 Sept 2009
Nature Genetics

Volume: 41, P: 1110-1115
Bringing sensation to prosthetic hands—chronic assessment of implanted thin-film electrodes in humans

Paul Čvančara
Giacomo Valle
Thomas Stieglitz
ResearchOpen Access19 Nov 2023
npj Flexible Electronics

Volume: 7, P: 1-14
Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration

Cristina Martínez-Fernández de la Cámara
Alberto M. Hernández-Pinto
Regina Rodrigo
ResearchOpen Access14 Jul 2015
Scientific Reports

Volume: 5, P: 1-13
Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection

Infection with HIV-1 is currently incurable as HIV-1 can persist as integrated provirus in the genome of latently infected CD4⁺T cells, where it is invisible to the immune system and not responsive to drugs. Here, Ferrari and colleagues discuss the development of novel engineered bispecific and trispecific antibodies, particularly dual-affinity re-targeting (DART) proteins, designed to eradicate latently infected cells.

Guido Ferrari
Barton F. Haynes
Georgia D. Tomaras
Reviews07 Oct 2016
Nature Reviews Drug Discovery

Volume: 15, P: 823-834
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

Philippe Froguel and colleagues report an association of variants near the gene encoding melatonin receptor 2 with fasting glucose levels and risk of type 2 diabetes. The association suggests a possible link between circadian rhythm and glucose homeostasis.

Nabila Bouatia-Naji
Amélie Bonnefond
Philippe Froguel
Research07 Dec 2008
Nature Genetics

Volume: 41, P: 89-94
ONE-YEAR FOLLOW-UP OF MENTAL/MOTOR DEVELOPMENT AND GROWTH IN CHILDREN AFTER SUCCESSFUL LIVER TRANSPLANTATION

Sunita H Stewart
Ricardo Uauy
Walter Andrews
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 278
MENTAL FUNCTION AND GROWTH IN CHILDREN WITH EARLY (E) VS. LATE (L) ONSET END-STAGE LIVER DISEASE (ESLD)

Sunita M Stewart
Ricardo Uauy
Walter Andrews
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 278
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by viruses with cytotoxic T lymphocyte escape mutations, with potential implications for the development of therapeutic vaccines.

Kai Deng
Mihaela Pertea
Robert F. Siliciano
Research07 Jan 2015
Nature

Volume: 517, P: 381-385
DNA barcode reveals occurrence of threatened species and hidden diversity on Teleost fish trade in the Coastal Amazon

Paula Santana
Thais Martins
Grazielle Evangelista-Gomes
ResearchOpen Access13 Nov 2023
Scientific Reports

Volume: 13, P: 1-16

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