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Using inbred medaka strains, the authors mapped 59 genetic loci linked to heart rate. Gene editing validated conserved genes affecting heart rate and morphology, highlighting the power of isogenic strains in uncovering mechanisms of cardiac traits and disease.

Squeezed light field microscopy (SLIM) combines ideas from tomography and compressed sensing with light field microscopy to enable volumetric imaging at kilohertz rates, as demonstrated in blood flow imaging in zebrafish and voltage imaging in leeches and mice.

Head motion is an artifact in structural and functional MRI signals, and some traits or groups are more strongly correlated with motion than others. Here the authors describe a method to attribute a motion impact score to specific trait-functional connectivity relationships.

Different types of SETBP1 variants cause variable developmental syndromes with only partial clinical and functional overlaps. Here, the authors report that SETBP1 variants outside the degron region impair DNA-binding, transcription, and neuronal differentiation capacity and morphologies.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Genomic deletions in poxviruses are not well understood, the authors found large deletions in >2% of Mpox virus genomes during routine surveillance, highlighting their role in poxvirus evolution and potential impact on diagnostics and therapeutics.

The author demonstrates that laser-driven ultracold Fermi gases can exhibit color-orbit-like coupling with SU(3) symmetry. This leads to color-like oscillations and other quantum-chromodyamics-like phenomena in an atomic physics laboratory.

Lithium-ion batteries rely on lithium diffusion within particles, traditionally assumed to follow concentration gradients. Here, authors use X-ray microscopy to track lithium movement in single particles, discovering that lithium can move against concentration gradients due to strain effects.

Temporal interference stimulation is thought to act via low-frequency envelope demodulation. Here, the authors demonstrate that stimulation thresholds in TIS follow the same carrier frequency dependence as direct kHz stimulation, indicating a shared biophysical mechanism.

KCNQ1 (Kv7.1) channels are critical for heart rhythm homeostasis. Here, the authors report the KCNQ1 structure in an intermediate state, revealing unique S1–S2 conformations that illuminate channel gating and may aid targeted drug development.

Here the authors develop a genetic priority score to predict side effects by integrating multiple lines of genetic evidence. By applying this score, they provide evidence of known side effects and suggest ones with no clinical trial evidence.

A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new therapeutic target to improve cancer immunotherapies.

The authors identify defective viral particles, in people with non-suppressible HIV-1, that can replicate through superinfection and interfere with the wild-type virus. However, they show no evidence of these preventing disease progression in the individuals studied.

Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.

The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

The BabyScreen+ study offered genomic screening to 1,000 newborns in Australia, and showed that the approach is feasible and positively received by families, leading to molecular diagnoses in 1.6% of babies.

The authors report on an experimental study of attosecond time delays of photoelectrons emitted from CO₂ molecules. This clarifies the role of internal dynamics of ions and ionelectron entanglement on the photoionization dynamics.

The electronic ground state of a correlated oxide interface is reversibly switched by light. Stemming from interfacial reconstructions, electrostatic confinement and photodoping, this effect opens a path towards engineering the optical response of oxides.

High-harmonic spectroscopy provides attosecond-scale information about optical processes in molecules. Present techniques, however, cannot simultaneously measure the phase as a function of molecular angle and photon frequency. An approach that retrieves both the amplitude and the phase of high-harmonic emission is now demonstrated, and could enable a full reconstruction of the molecular wavefunction.

Analyses of consummatory reproductive behaviours in male mice uncover a brain mechanism whereby an internal state can attribute a social quality to a generic touch to initiate purposeful reproductive actions.

Neuroinflammation following intracortical microelectrode implantation impairs long-term brain-machine interface performance. Here, the authors developed a nanoparticle-based therapy that improves local hemostasis and delivers dexamethasone, reducing inflammation.

An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72 epitopes that are recognized.

A fresh approach to protein design that incorporates excited intermediate states enables precise control over the lifetime of protein interactions, with potential applications in cell-signalling modulation and in biosensors and synthetic circuits.

In strongly correlated systems, how magnetic excitations are renormalized by charge carriers remains an open question. An experiment now reports the observation of magnon-polarons—magnons dressed by doped holes—in a Fermi–Hubbard quantum simulator.

Scoliosis is a common yet poorly understood pediatric disorder. Using zebrafish disease models, Pumputis et al. identify pervasive cell stress responses as causing spine deformity and present possibilities for new therapies and diagnostic tools.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Kaposi’s Sarcoma-associated Herpesvirus encodes ORF74, a GPCR driving oncogenesis through high basal signaling. Here, authors present cryoEM structures of both inactive and active states, revealing the structural basis for its ligand promiscuity and spontaneous activation.

The ability to resist compaction has widespread implications for reverse osmosis (RO) membrane technology. Here the authors present a class of thin-film crosslinked composite reverse osmosis membranes that resist physical compaction at ultrahigh pressures.

The development of soluble Notch agonists is a challenge because of the mechanical forces needed to activate Notch receptors. Here, bispecific Notch agonist proteins were designed that ‘pull’ on and activate Notch receptors in the presence of desired biomarkers.

Tilt-corrected bright-field scanning transmission electron microscopy offers enhanced cryogenic electron microscopy contrast and substantial improvement in dose efficiency for thick samples such as bacterial cells and large organelles, while still being able to perform single-particle analysis.

Proteins interact with both the exterior and interior of microtubules. Here the relationship between microtubule building blocks and the accessibility of the microtubule interior to proteins is clarified.

Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with diffraction-limited spatial resolution and temporal resolution of 0.3 s for imaging a full cell volume.

Some bacterial species display gliding motility associated with slime secretion through nozzle-like structures at the cell poles. Here, Zuckerman, So & Hoiczyk show that the nozzles are composed of PilQ/GspD proteins usually associated with protein secretion, thus suggesting that secretins may be required for the secretion of non-proteinaceous polymers in these bacteria.

In Drosophila, coherent slow-wave activity between sleep-promoting and locomotion-promoting neural networks provides a brain state structure that allows for quiescent behaviours.

Enfortumab vedotin (EV) is the current standard treatment for advanced bladder cancer, but resistance typically develops within a year, highlighting the need for new therapies. This study demonstrates that NECTIN4-targeting CAR T cells are effective against bladder cancer, including EV-resistant cells, and their potency can be further enhanced by using rosiglitazone to boost NECTIN4 expression.

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

A strongly lensed galaxy at redshift z ≈ 6 is resolved into at least 15 star-forming clumps embedded in a rotating disk. Clump formation in this system, which is not predicted by cosmological zoom-in simulations, may be driven by disk instabilities with weak feedback, rather than past mergers.

The presented Mean-Shift Super Resolution (MSSR) algorithm can extend spatial resolution within a single microscopy image. Its applicability extends across a wide range of experimental and instrumental configurations and it is compatible with other super-resolution microscopy approaches.

Content-aware frame interpolation (CAFI) improves the temporal resolution in time-lapse imaging by accurately predicting images in between image pairs. By allowing fewer frames to be imaged, CAFI also enables gentler live-cell imaging.

Mass spectrometry-based lipidomics and metabolomics generate large, complex datasets requiring effective analysis. Here, authors review key statistical and visualization methods alongside widely used R and Python tools, and provide a GitBook with step-by-step code for accessible, reproducible data analysis.

Brown et al. show that mouse islet progenitors with different transcriptomes produce distinct β-cell subtypes and maternal diet alter the subtype proportions. Similar β-cell subsets exist in humans, with a subset enriched in genes related to β cell function reduced in diabetes.

Al-Hilal, Chrysovergi et al. identify a role for durotaxis in lung fibrosis and metastatic pancreatic cancer, mediated by the FAK–paxillin mechanosensor complex, and demonstrate therapeutic targeting of this pathway using the small molecule JP-153.

Quantum computing relies on logic gates operated by different pulse sequences, but their efficiency is limited by decoherence. Yan et al.identify an analogy between free- and driven-evolution sequences, and use it to develop a driven-evolution-based noise spectroscopy on a superconducting flux qubit.

Errors in oocyte division can cause infertility and birth defects. Here, authors combine a genetic strategy with a novel optochemical tool to show that spindle pole-localized F-actin is essential for proper meiotic spindle assembly and chromosome segregation.

Using voltage imaging, the authors show that interneurons in the hippocampus sharpen memory-encoding-activity by increasing the signal-to-noise ratio of pyramidal neuron sensory representations during working memory in mice.