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Showing 1–8 of 8 results
Advanced filters: Author: David M. Shechner Clear advanced filters

  • In the RNA world, there would have been ribozymes able to catalyze RNA replication. An artificial ribozyme able to catalyze RNA-templated RNA polymerization has been developed. Now biochemical work and crystal structures of this ribozyme's catalytic core trapped in a state prior to catalysis reveal the complex catalytic strategies it employs.

    • David M Shechner
    • David P Bartel
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1036-1042

  • Argonaute proteins are an essential part of the guide-RNA–protein complex that carries out RNA-induced gene silencing; structure–function studies of the yeast complex reveal conserved features of the eukaryotic complex, which underlie formation of the catalytically active conformation.

    • Kotaro Nakanishi
    • David E. Weinberg
    • Dinshaw J. Patel
    Research
    Nature
    Volume: 486, P: 368-374

  • Crystallization of RNA molecules can pose a challenge, and the U1A RNA binding protein has been used to facilitate the process. Now a different portable RNA sequence and a synthetic Fab are presented as tools for RNA structural determination. In addition to functioning as a crystallization chaperone, the Fab also serves as the search model to provide phase information.

    • Yelena Koldobskaya
    • Erica M Duguid
    • Joseph A Piccirilli
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 100-106