Nature Search

Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Crystal structure of E.coli RuvA with bound DNA Holliday junction at 6 Å resolution

David Hargreaves
David W. Rice
John B. Rafferty
Research01 Jun 1998
Nature Structural Biology

Volume: 5, P: 441-446
Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments

Madrer et al. identify a Parkinson’s disease–specific increase in transfer RNA (tRNA) fragments in human blood, cerebrospinal fluid and postmortem brain tissue, demonstrating the ability of blood-based tRNA fragment quantification to distinguish between pre-symptomatic patients and healthy controls.

Nimrod Madrer
Shani Vaknine-Treidel
Hermona Soreq
ResearchOpen Access11 Apr 2025
Nature Aging

Volume: 5, P: 868-882
What makes a good science writer?

David Fishlock is Science Editor of the Financial Times.

David Fishlock
Research30 Aug 1974
Nature

Volume: 250, P: 747-749
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 331-341
Could blockade of Notch signalling promote fracture repair?

David Killock
Research Highlights26 Nov 2013
Nature Reviews Rheumatology

Volume: 10, P: 3
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Structure-based drug discovery of cereblon (CRBN)-recruiting protein degraders has been to date challenging due to limitations with current constructs for recombinant protein expression. In this work, the authors design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders.

Alena Kroupova
Valentina A. Spiteri
Alessio Ciulli
ResearchOpen Access15 Oct 2024
Nature Communications

Volume: 15, P: 1-14
The peculiar colours of the halo light in the edge-on spiral galaxy NGC5907

Richard J. Rudy
Charles E. Woodward
David E. Harker
Research08 May 1997
Nature

Volume: 387, P: 159-161
Large-scale structure in a universe with mixed hot and cold dark matter

Marc Davis
F. J. Summers
David Schlegel
Research01 Oct 1992
Nature

Volume: 359, P: 393-396
Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division

SPOR domains are present in bacterial proteins that recognize cell-wall peptidoglycan strands stripped of the peptide stems. Here, Alcorlo et al. show that, indeed, the presence of peptide stems abrogates binding to a SPOR domain, and provide insights into the molecular basis for recognition.

Martín Alcorlo
David A. Dik
Juan A. Hermoso
ResearchOpen Access05 Dec 2019
Nature Communications

Volume: 10, P: 1-13
Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

Aberrant ion transporter expression disrupts osmoregulation in many cancers. Here, the authors introduce an executable model of osmotic regulation and membrane transport, illuminating the mechanistic basis of multiple cellular cancer phenotypes and suggesting therapeutic avenues.

David Shorthouse
Angela Riedel
Benjamin A. Hall
ResearchOpen Access01 Aug 2018
Nature Communications

Volume: 9, P: 1-15
On the reported detection of sub-GeV antiprotons in galactic cosmic rays

David Eichler
Research04 Feb 1982
Nature

Volume: 295, P: 391-393
Madness or Badness ?

DAVID R. JENKINS
Correspondence03 Nov 1972
Nature

Volume: 240, P: 59
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

TSPO PET imaging is widely used to quantify microglial activation. Here, the authors show that TSPO expression increases in activated rodent but not human microglia, implying that in humans TSPO informs on microglial density rather than activation status.

Erik Nutma
Nurun Fancy
David R. Owen
ResearchOpen Access28 Aug 2023
Nature Communications

Volume: 14, P: 1-25
Complex water networks visualized by cryogenic electron microscopy of RNA

Using cryogenic electron microscopy and a modelling approach, complex water networks in a ribozyme are visualized.

Rachael C. Kretsch
Shanshan Li
Wah Chiu
ResearchOpen Access11 Mar 2025
Nature

Volume: 642, P: 250-259
Mapping the space of chemical reactions using attention-based neural networks

Organic chemical reactions can be divided into classes that allow chemists to use the knowledge they have about optimal conditions for specific reactions in the context of other reactions of similar type. Schwaller et al. present here an efficient method based on transformer neural networks that learns a chemical space in which reactions of a similar class are grouped together.

Philippe Schwaller
Daniel Probst
Jean-Louis Reymond
Research28 Jan 2021
Nature Machine Intelligence

Volume: 3, P: 144-152
Texas prepares to fight for stem cells

Enthusiasm for unapproved treatments worries regulators.

David Cyranoski
News20 Sept 2011
Nature
HOXA9 has the hallmarks of a biological switch with implications in blood cancers

HOXA9 plays an important role in acute myeloid leukaemia (AML), but its relevance for other blood malignancies is unclear. Here, the authors show that HOXA9 has a binary switch function that can clinically stratify AML patients, and model how the interactions with JAK2, TET2 and NOTCH impact myeloproliferative neoplasms.

Laure Talarmain
Matthew A. Clarke
Benjamin A. Hall
ResearchOpen Access03 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Long-term culture of murine erythropoietic progenitor cells in the absence of an adherent layer

Françoise Wendling
Mona M. Shreeve
Arthur A. Axelrad
Research13 Oct 1983
Nature

Volume: 305, P: 625-627
Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

A post eradication polio vaccine should be safe and easy to produce. Here, the authors characterize a recombinant virus-like particle polio vaccine with stabilized capsid proteins and show comparable immunogenicity to the current inactivated polio vaccine.

Lee Sherry
Mohammad W. Bahar
David J. Rowlands
ResearchOpen Access18 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

The factors influencing risk of reinfection with SARS-CoV-2 are poorly understood. Here, the authors use data from the UK COVID-19 Infection Survey, a community based longitudinal study, to assess characteristics of ~45,000 reinfections compared to initial infections.

Jia Wei
Nicole Stoesser
Chris Cunningham
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-14
The DNA sequence of the human X chromosome

Mark T. Ross
Darren V. Grafham
David R. Bentley
Research17 Mar 2005
Nature

Volume: 434, P: 325-337
MATERNAL-FETAL TRANSFER OF MELATONIN IN THE NON-HUMAN PRIMATE

Steven M Reppert
Ronald A Chez
David C Klein
Research01 Jun 1979
Pediatric Research

Volume: 13, P: 788-791
Parental origin of mutations of the retinoblastoma gene

Thaddeus P. Dryja
Shizuo Mukai
David W. Yandell
Research15 Jun 1989
Nature

Volume: 339, P: 556-558
Nucleosynthesis, neutrino bursts and γ-rays from coalescing neutron stars

David Eichler
Mario Livio
David N. Schramm
Research13 Jul 1989
Nature

Volume: 340, P: 126-128
Activation of a carbon–carbon bond in solution by transition-metal insertion

Michael Gozin
Alexander Weisman
David Milstein
Research19 Aug 1993
Nature

Volume: 364, P: 699-701
Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I

David G. Drubin
Jon Mulholland
David Botstein
Research18 Jan 1990
Nature

Volume: 343, P: 288-290
Structure of a major immunogenic site on foot-and-mouth disease virus

Derek Logan
Robin Abu-Ghazaleh
Elizabeth Fry
Research08 Apr 1993
Nature

Volume: 362, P: 566-568
Minutes-duration optical flares with supernova luminosities

Observations of optical flares from AT2022tsd (the ‘Tasmanian Devil’) show that they have durations on the timescale of minutes, occur over a period of months, are highly energetic, are probably nonthermal and have supernova luminosities.

Anna Y. Q. Ho
Daniel A. Perley
WeiKang Zheng
Research15 Nov 2023
Nature

Volume: 623, P: 927-931
Comprehensive molecular characterization of mitochondrial genomes in human cancers

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Yuan Yuan
Young Seok Ju
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 342-352
Butler enables rapid cloud-based analysis of thousands of human genomes

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Biotechnology

Volume: 38, P: 288-292
Multi-platform assessment of transcriptome profiling using RNA-seq in the ABRF next-generation sequencing study

For intact RNA, gene expression profiles from rRNA-depletion and poly-A enrichment are similar. In addition, rRNA- depletion enables effective analysis of degraded RNA samples.

Sheng Li
Scott W Tighe
Christopher E Mason
Research24 Aug 2014
Nature Biotechnology

Volume: 32, P: 915-925
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
A chemo-centric view of human health and disease

Forecasting unwanted interactions between drugs and chemicals in human body is an important but yet unmet need. Here the authors build networks that can predict comorbidities and drug side effects, by analysing the existing database that compiles effects of drugs and chemicals on human conditions.

Miquel Duran-Frigola
David Rossell
Patrick Aloy
Research01 Dec 2014
Nature Communications

Volume: 5, P: 1-11
Small and slippery

David Jones
News & Views08 Feb 1996
Nature

Volume: 379, P: 496
Considering cosmology

David W. Hughes
Books & Arts31 Oct 1991
Nature

Volume: 353, P: 804-805
Sunny planet

David Morrison
Books & Arts29 Jun 1989
Nature

Volume: 339, P: 672-673
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

By integrating large-scale genomic and proteomic data in cerebrospinal fluid and plasma, the authors identify 49 proteins linked to MRI markers of cerebral small vessel disease, highlighting extracellular matrix and immune pathways, with biomarker and therapeutic potential.

Ilana Caro
Daniel Western
Stéphanie Debette
ResearchOpen Access20 Nov 2025
Nature Aging

Volume: 5, P: 2514-2531
Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides

PDL1 expression is a common biomarker for immunotherapy response in cancer, and it is usually quantified using immunohistochemistry. Here, the authors develop a weakly supervised learning approach combining multiple instance learning and a teacher-student framework to predict PDL1 expression from histopathological imaging.

Darui Jin
Shangying Liang
Xiangzhi Bai
ResearchOpen Access09 Apr 2024
Nature Communications

Volume: 15, P: 1-14
High resolution structures of HIV-1 RT from four RT–inhibitor complexes

Jingshan Ren
Robert Esnouf
David Stammers
Research01 Apr 1995
Nature Structural Biology

Volume: 2, P: 293-302
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Author Correction: Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

Victoria Roulstone
Joan Kyula-Currie
Kevin J. Harrington
Amendments and CorrectionsOpen Access15 Jul 2025
Nature Communications

Volume: 16, P: 1
Two distinct epithelial-to-mesenchymal transition programs control invasion and inflammation in segregated tumor cell populations

Youssef et al. study epithelial-to-mesenchymal transition (EMT) programs in breast cancer and identify two interdependent trajectories coexisting within tumors, with EMT transcription factors such as PRRX1 at their nexus.

Khalil Kass Youssef
Nitin Narwade
M. Angela Nieto
ResearchOpen Access16 Oct 2024
Nature Cancer

Volume: 5, P: 1660-1680
Strong coupling between chlorosomes of photosynthetic bacteria and a confined optical cavity mode

Photosynthetic bacteria growing in low light environments have evolved to use small amounts of light with high efficiency. Here, Coles et al. demonstrate strong exciton–photon coupling of about 1,000 chlorosomes to a confined cavity mode thus modifying the energy levels of the light-harvesting process.

David M. Coles
Yanshen Yang
Jason M. Smith
Research28 Nov 2014
Nature Communications

Volume: 5, P: 1-9
The subtle taste of Jupiter

David J. Stevenson
News & Views08 Feb 1996
Nature

Volume: 379, P: 495-496
Blood flukes have a double outer membrane

DIANE J. MCLAREN
DAVID J. HOCKLEY
Research01 Sept 1977
Nature

Volume: 269, P: 147-149
Structural similarities between Thy-1 antigen from rat brain and immunoglobulin

David G. Campbell
Alan F. Williams
Kenneth B. M. Reid
Research15 Nov 1979
Nature

Volume: 282, P: 341-342
Merizo: a rapid and accurate protein domain segmentation method using invariant point attention

Proteins contain modular structural and functional units called domains. Here, the authors have developed Merizo, a deep learning method for domain segmentation applicable to experimental structures as well as those generated by AlphaFold2.

Andy M. Lau
Shaun M. Kandathil
David T. Jones
ResearchOpen Access19 Dec 2023
Nature Communications

Volume: 14, P: 1-11
In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development

Pathway analysis aids interpretation of large-scale gene expression data, but existing algorithms fall short of providing robust pathway identification. The method introduced here includes coexpression analysis and gene importance estimation to robustly identify relevant pathways and biomarkers for patient stratification.

Ivan V. Ozerov
Ksenia V. Lezhnina
Alex Zhavoronkov
ResearchOpen Access16 Nov 2016
Nature Communications

Volume: 7, P: 1-11
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Estimates of infection rates from the UK COVID-19 Infection Survey may have been biased by the characteristics of people who chose to take part. Here, the authors show that the survey population had unusually high vaccination rates and adjust infection estimates taking this into account.

Koen B. Pouwels
David W. Eyre
Chris Cunningham
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-12

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