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A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

The human genome still contains numerous uncharacterized genes. Here, the authors identify a fast evolving Factor associated with Metabolism and Energy (FAME) that is associated with altered body weight, energy expenditure, and metabolism and study its function in knockout mouse models.

Julian Petersen
Lukas Englmaier
Igor Adameyko
ResearchOpen Access29 May 2023
Nature Communications

Volume: 14, P: 1-22
Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

Julian Petersen
Lukas Englmaier
Igor Adameyko
Amendments and CorrectionsOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1
WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

WNTs can signal over long distances but how this arises in the brain is unclear. Here, the authors show that WNT5A is secreted from the choroid plexus of the developing hindbrain (but not the telencephalon) and transported in the CSF with lipoprotein particles in order to control cerebellar morphogenesis.

Karol Kaiser
Daniel Gyllborg
Vítězslav Bryja
ResearchOpen Access02 Apr 2019
Nature Communications

Volume: 10, P: 1-15
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1

CDK11 associates with SF3B1 and phosphorylates threonine residues at the N terminus of SF3B1 during spliceosome activation, and the inhibition of CDK11 blocks the activation and leads to widespread intron retention and the accumulation of non-functional spliceosomes on pre-mRNAs and chromatin.

Milan Hluchý
Pavla Gajdušková
Dalibor Blazek
Research14 Sept 2022
Nature

Volume: 609, P: 829-834
A hybrid DDA/DIA-PASEF based assay library for a deep proteotyping of triple-negative breast cancer

Petr Lapcik
Klara Synkova
Pavel Bouchal
ResearchOpen Access18 Jul 2024
Scientific Data

Volume: 11, P: 1-7
Unveiling the role of sex in the metabolism of indoxyl sulfate and apixaban

Blanca Pina-Beltran
Daniel Dimitrov
Stéphane Burtey
ResearchOpen Access19 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy

Sarala Raj Murthi
Andreas Petry
Cordula M. Wolf
ResearchOpen Access16 Jan 2025
Scientific Reports

Volume: 15, P: 1-22
Catechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer

Lucia Janacova
Michaela Stenckova
Pavel Bouchal
ResearchOpen Access23 Jan 2023
Scientific Reports

Volume: 13, P: 1-14
p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse blastocyst primitive endoderm differentiation.

Pablo Bora
Lenka Gahurova
Alexander W. Bruce
ResearchOpen Access25 Jun 2021
Communications Biology

Volume: 4, P: 1-19
A novel type I cystatin of parasite origin with atypical legumain-binding domain

Jana Ilgová
Lucie Jedličková
Martin Kašný
ResearchOpen Access13 Dec 2017
Scientific Reports

Volume: 7, P: 1-12

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