TBK1 mutations are linked to Amyotrophic Lateral Sclerosis (ALS) and Fronto-temporal dementia (FTD), but their cell-type specific disease contributions are unclear. Here, the authors show that Tbk1 deletion from mouse microglia shifts them to an aged-like phenotype and causes social recognition deficits.
- Isadora Lenoel
- Matthieu Ribon
- Christian S. Lobsiger
