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Showing 1–15 of 15 results

Advanced filters: Author: David Schrama Clear advanced filters

MEK5/ERK5 inhibition sensitizes NRAS-mutant melanoma to MAPK-targeted therapy by preventing Cyclin D/CDK4-mediated G1/S progression

Rupesh Paudel
Simon Goller
Marc Schmidt
ResearchOpen Access06 Oct 2025
Cell Death & Disease

Volume: 16, P: 1-10
One Health approach uncovers emergence and dynamics of Usutu and West Nile viruses in the Netherlands

Arboviruses are climate sensitive, and their global distributions are changing. Here, the authors describe results of a One Health study programme to investigate the occurrence of Usutu and West Nile Virus in the Netherlands, a previously non-endemic area.

Emmanuelle Münger
Nnomzie C. Atama
Marion P. G. Koopmans
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Impact of ocean stratification on submarine melting of a major Greenland outlet glacier

Fiammetta Straneo
Ruth Curry
Leigh Stearns
ResearchOpen Access11 Feb 2011
Nature Precedings

P: 1
Antibody targeted drugs as cancer therapeutics

Targeting drugs specifically to tumour cells to improve efficacy and reduce toxicity is paramount to the future development of anti-cancer agents. Schrama and colleagues critically review current approaches to achieving this and the status of targeted treatments in development.

David Schrama
Ralph A. Reisfeld
Jürgen C. Becker
Reviews20 Jan 2006
Nature Reviews Drug Discovery

Volume: 5, P: 147-159
Mass balance of the Greenland Ice Sheet from 1992 to 2018

Three techniques for estimating mass losses from the Greenland Ice Sheet produce comparable results for the period 1992–2018 that approach the trajectory of the highest rates of sea-level rise projected by the IPCC.

Andrew Shepherd
Erik Ivins
Jan Wuite
Research10 Dec 2019
Nature

Volume: 579, P: 233-239
Mass balance of the Antarctic Ice Sheet from 1992 to 2017

Andrew Shepherd
Erik Ivins
Bert Wouters
Research13 Jun 2018
Nature

Volume: 558, P: 219-222
A phase Ib dose-escalation and expansion study of the oral MEK inhibitor pimasertib and PI3K/MTOR inhibitor voxtalisib in patients with advanced solid tumours

Alison M. Schram
Leena Gandhi
Rebecca S. Heist
ResearchOpen Access14 Nov 2018
British Journal of Cancer

Volume: 119, P: 1471-1476
Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma

Cathrin Ritter
Kaiji Fan
Jürgen C. Becker
ResearchOpen Access23 Feb 2016
Scientific Reports

Volume: 6, P: 1-14
Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

Cathrin Ritter
Kaiji Fan
Jürgen C. Becker
ResearchOpen Access23 May 2017
Scientific Reports

Volume: 7, P: 1-11
Characterization of Insulin-Like Growth Factor Binding Protein-3 in Chronic Renal Failure Serum

David R Powell
Francis Liu
Raymond L Hintz
Research01 Feb 1993
Pediatric Research

Volume: 33, P: 136-143
Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

Kaiji Fan
Ivelina Spassova
Jürgen C. Becker
ResearchOpen Access11 Dec 2020
Oncogene

Volume: 40, P: 980-996
Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas

Thibault Kervarrec
Anne Tallet
Serge Guyétant
Research22 Oct 2018
Modern Pathology

Volume: 32, P: 499-510
Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma

Thibault Kervarrec
Anne Tallet
Serge Guyétant
Research14 Jun 2019
Modern Pathology

Volume: 32, P: 1605-1616
Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy

Charlotte S. Walmsley
Philip Jonsson
Alison M. Schram
ResearchOpen Access14 Feb 2024
npj Precision Oncology

Volume: 8, P: 1-6
Predicting the structure of soil communities from plant community taxonomy, phylogeny, and traits

Jonathan W. Leff
Richard D. Bardgett
Noah Fierer
Research09 Mar 2018
The ISME Journal

Volume: 12, P: 1794-1805

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MEK5/ERK5 inhibition sensitizes NRAS-mutant melanoma to MAPK-targeted therapy by preventing Cyclin D/CDK4-mediated G1/S progression

One Health approach uncovers emergence and dynamics of Usutu and West Nile viruses in the Netherlands

Impact of ocean stratification on submarine melting of a major Greenland outlet glacier

Antibody targeted drugs as cancer therapeutics

Mass balance of the Greenland Ice Sheet from 1992 to 2018

Mass balance of the Antarctic Ice Sheet from 1992 to 2017

A phase Ib dose-escalation and expansion study of the oral MEK inhibitor pimasertib and PI3K/MTOR inhibitor voxtalisib in patients with advanced solid tumours

Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

Characterization of Insulin-Like Growth Factor Binding Protein-3 in Chronic Renal Failure Serum

Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas

Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma

Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy

Predicting the structure of soil communities from plant community taxonomy, phylogeny, and traits

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