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Showing 1–50 of 1288 results
Advanced filters: Author: David W. M. Tan Clear advanced filters
  • The author demonstrates that laser-driven ultracold Fermi gases can exhibit color-orbit-like coupling with SU(3) symmetry. This leads to color-like oscillations and other quantum-chromodyamics-like phenomena in an atomic physics laboratory.

    • Chetan S. Madasu
    • Chirantan Mitra
    • David Wilkowski
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • In an integrated analysis of transcriptomic data from the SUBSPACE consortium and public datasets of patients with sepsis, acute respiratory distress syndrome, trauma and burns, dysregulation within four consensus molecular clusters related to myeloid and lymphoid cells is associated with mortality and illness severity.

    • Andrew R. Moore
    • Hong Zheng
    • Purvesh Khatri
    ResearchOpen Access
    Nature Medicine
    P: 1-13
  • Nematicity, the spontaneous breaking of lattice rotational symmetry, plays an important role in kagome metals. Here, the authors report on a nematic phase within seven Kelvin below the charge density wave transition in the bilayer kagome metal ScV6Sn6.

    • Camron Farhang
    • William R. Meier
    • Jing Xia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Khufu’s Pyramid is one of the largest archaeological monuments in the world, and still contains unexplored voids. Here, the authors use cosmic-ray muon radiography in multiple positions to precisely characterize one of these inner structures called the North Face Corridor.

    • Sébastien Procureur
    • Kunihiro Morishima
    • Mohamed Elkarmoty
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

    • Erin M. Buchanan
    • Kelly Cuccolo
    • Savannah C. Lewis
    Research
    Nature Human Behaviour
    P: 1-20
  • NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

    • Junyi Ju
    • Aiping Chen
    • Quan Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14
  • TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

    • Jeff Yat-Fai Chung
    • Philip Chiu-Tsun Tang
    • Patrick Ming-Kuen Tang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • Introduction of structured neutron waves carrying orbital angular momentum (OAM) in small-angle neutron scattering experiments provides novel approaches to the characterisation of material properties. Here the authors demonstrate the retrieval of phase information in far-field intensity profiles by means of an interferometric technique using helical neutron waves.

    • Dusan Sarenac
    • Melissa E. Henderson
    • Dmitry A. Pushin
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-6
  • Transition metal nitride coatings exhibit high hardness, but typically lack ductility and are therefore prone to failure. Here, the effect of bilayer thickness on the mechanical properties of MoN-TaN superlattices is investigated, leading to coatings with high fracture toughness.

    • Rainer Hahn
    • Nikola Koutná
    • Paul H. Mayrhofer
    ResearchOpen Access
    Communications Materials
    Volume: 1, P: 1-11
  • Broad-spectrum vaccines have been proposed as a tool for rapid response to emerging infectious disease threats and are in pre-clinical development. Here, the authors use mathematical modelling to assess the potential impacts of broadly protective sarbecovirus vaccines for a hypothetical “SARS-X” outbreak.

    • Charles Whittaker
    • Gregory Barnsley
    • Azra C. Ghani
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

    • Marek Cmero
    • Ke Yuan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • The Schrödinger impact event carved two canyons on the moon comparable in size to the Grand Canyon of North America. The directions of those canyons imply little debris covers the > 4-billion-year-old units that will be explored by Artemis astronauts.

    • David A. Kring
    • Danielle P. Kallenborn
    • Gareth S. Collins
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7
  • Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

    • Esther Rheinbay
    • Morten Muhlig Nielsen
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 102-111
  • STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

    • Xihao Li
    • Zilin Li
    • Xihong Lin
    Research
    Nature Genetics
    Volume: 52, P: 969-983
  • There are limited in vitro and in vivo models to study human fetal exposure to environmental noise. Here, the authors develop a computational model to quantify fetal exposure to acoustic fields, obtaining acoustic transfer characteristics across the human audio range.

    • Pierre Gélat
    • Elwin van’t Wout
    • Eric Jauniaux
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

    • Shimin Shuai
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Neel domain walls are typically stabilized by an interfacial Dzyaloshinskii-Moriya interaction, with a chirality that is fixed by the sample materials. Here, Song, Huang and coauthors demonstrate the existence of two bistable Néel domain wall states with opposite chiralities, and the switching between these via magnetic field pulses

    • Yixuan Song
    • Siying Huang
    • Geoffrey S. D. Beach
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136
  • In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

    • Yiqun Zhang
    • Fengju Chen
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

    • Lina Sieverling
    • Chen Hong
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121
  • Direct human actions such as hunting and bird deterrence at aquaculture sites kill up to 10% of the populations of some shorebird species migrating along China’s coast each year, suggesting that this direct mortality is an overlooked threat to migratory populations.

    • Dan Liang
    • Tong Mu
    • David S. Wilcove
    Research
    Nature Ecology & Evolution
    P: 1-12
  • Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

    • Vinayak Bhandari
    • Constance H. Li
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10
  • Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

    • Marta Paczkowska
    • Jonathan Barenboim
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

    • Yulia Rubanova
    • Ruian Shi
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101