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Showing 51–100 of 278 results
Advanced filters: Author: David W. Wyatt Clear advanced filters
  • Using cryo-electron tomography, Lopez-Robles, Scaramuzza, Astorga-Simon, Ishida et al. solve the architecture of ESCPE-1, a protein scaffold that mediates the recycling of cargo from endosome to trans-Golgi network and plasma membrane in tubular carriers.

    • Carlos Lopez-Robles
    • Stefano Scaramuzza
    • Aitor Hierro
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 958-969
  • Structural studies of human polysialyltransferase ST8SialII in apo form and in complex with donor sugar and sulfated glycan acceptor shed light on the substrate binding and specificity as well as the catalytic activity of this class of polysialyltransferases.

    • Gesa Volkers
    • Liam J Worrall
    • Natalie C J Strynadka
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 627-635
  • The S9.6 monoclonal antibody is widely used to map R-loops genome wide. Here, Bou-Nader et al., define the nucleic acid-binding specificity of S9.6 and report its crystal structures free and bound to a hybrid, which reveal the asymmetric recognition of the RNA and DNA strands and its A-form conformation.

    • Charles Bou-Nader
    • Ankur Bothra
    • Jinwei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14
  • The immunoglobulin domain framework of antibodies has been a long standing design challenge. Here, the authors describe design rules for tailoring these domains and show they can be accurately designed, de novo, with high stability and the ability to scaffold functional loops.

    • Tamuka M. Chidyausiku
    • Soraia R. Mendes
    • Enrique Marcos
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14
  • Unphosphorylated PINK1 of Pediculus humanus corporis forms a dimerized state before undergoing trans-autophosphorylation, and phosphorylated PINK1 undergoes a conformational change in the N-lobe to produce its phosphorylated, ubiquitin-binding state.

    • Zhong Yan Gan
    • Sylvie Callegari
    • David Komander
    Research
    Nature
    Volume: 602, P: 328-335
  • The promoter variant rs35705950 confers a gain of function to the MUC5B gene and is the dominant risk factor for idiopathic pulmonary fibrosis. Here the authors show that mice overexpressing Muc5b in distal airspaces show impaired mucociliary clearance and increased susceptibility to bleomycin-induced lung fibrosis, and that both characteristics are reduced by treatment with a mucolytic agent.

    • Laura A. Hancock
    • Corinne E. Hennessy
    • David A. Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10
  • N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatment strategy for lymphoma patients.

    • Erwan Beauchamp
    • Megan C. Yap
    • Luc G. Berthiaume
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • The modification of proteins with O-linked β-N-acetylglucosamine (OGlcNAc) plays roles in regulation of numerous cellular functions while incorrect O-GlcNAcylation patterns are linked to disease. Here, the authors report a cryo-EM structure of full-length O-GlcNAc transferase (OGT), the only enzyme responsible for O-GlcNAcylation.

    • Richard W. Meek
    • James N. Blaza
    • Gideon J. Davies
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10
  • Rare mutations in the high requirement temperature protein A1 (HTRA1) cause cerebral vasculopathy. Here, authors establish mechanistically distinct protein repair approaches to reverse the deleterious effects of pathogenic mutations interfering with the assembly and protease function of HTRA1.

    • Nathalie Beaufort
    • Linda Ingendahl
    • Martin Dichgans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • Structures of the human sodium-dependent citrate transporter NaCT in complexes with citrate or a small-molecule inhibitor reveal how the inhibitor—which binds to the same site as citrate—arrests the transport cycle of NaCT.

    • David B. Sauer
    • Jinmei Song
    • Da-Neng Wang
    Research
    Nature
    Volume: 591, P: 157-161
  • Structural and biochemical analyses of human USP30 explain the basis of Lys6-linkage preference and regulation by PINK1 and Parkin, shedding light onto how USP30 can act as a brake on mitophagy.

    • Malte Gersch
    • Christina Gladkova
    • David Komander
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 920-930
  • Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

    • Jianxin Shi
    • Kouya Shiraishi
    • Qing Lan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • Modern land management often assumes that past human activity shaped iconic landscapes. This study finds that climate, rather than indigenous activity, controlled fire severity in New England, with open landscapes developing after deforestation for European agriculture.

    • W. Wyatt Oswald
    • David R. Foster
    • Deena L. Duranleau
    Research
    Nature Sustainability
    Volume: 3, P: 241-246
  • A technique for the de novo design of switchable protein systems controlled by induced conformational change is demonstrated for three functional motifs, in vitro and in yeast and mammalian cells.

    • Robert A. Langan
    • Scott E. Boyken
    • David Baker
    Research
    Nature
    Volume: 572, P: 205-210
  • Carbon isotopic analysis reveals global biogeographic traits in shark trophic interactions, and sheds light on the diverse foraging behaviour of sharks.

    • Christopher S. Bird
    • Ana Veríssimo
    • Clive N. Trueman
    Research
    Nature Ecology & Evolution
    Volume: 2, P: 299-305
  • Baker, Marcos and colleagues analyze β-arches (loops connecting unpaired β-strands) and derive rules used for de novo design of a hyperthermostable jellyroll structure, with eight antiparallel β-strands forming double-stranded β-helices.

    • Enrique Marcos
    • Tamuka M. Chidyausiku
    • David Baker
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 1028-1034
  • The authors determined high-resolution cryo-EM structures of the lentiviral intasome — the nucleoprotein complex that inserts viral DNA into a host chromosome — and show that the architecture comprising 16 integrase subunits is critical for its function.

    • Allison Ballandras-Colas
    • Vidya Chivukula
    • Peter Cherepanov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16
  • The cryo-electron microscopy structure of the glucocorticoid receptor (GR)-loading complex—a complex in which Hsp70 loads GR onto Hsp90 and Hop—is described, providing insights into how the chaperones Hsp90 and Hsp70 coordinate to facilitate GR remodelling for activation.

    • Ray Yu-Ruei Wang
    • Chari M. Noddings
    • David A. Agard
    Research
    Nature
    Volume: 601, P: 460-464
  • Leucine-rich repeats (LRRs) can form horseshoe-like structures with different curvatures in nature. A computational approach now allows the design of 12 new LRR proteins with precise curvatures, using defined building blocks and junction modules.

    • Keunwan Park
    • Betty W Shen
    • David Baker
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 167-174
  • Pathogen proteins targeting the actin cytoskeleton often serve as model systems to understand their eukaryotic analogs. Structure-function studies of the bacterial actin nucleator VopL suggest that dimerization and pointed-end binding play crucial roles in VopL-mediated nucleation, by enabling the formation of a hexameric pointed end actin nucleus, and that eukaryotic actin nucleators may also function as dimers or higher oligomers.

    • Suk Namgoong
    • Malgorzata Boczkowska
    • Roberto Dominguez
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1060-1067
  • Intrinsically disordered proteins (IDP) are pleotropic proteins with diverse functions. Here the authors show that an IDP, TgIST, from T. gondii blocks interferon-induced gene expression by binding to the STAT1 dimer interface and preventing the recruitment of co-transcriptional activators, CBP/p300, to STAT1 to inhibit expression of immunity genes.

    • Zhou Huang
    • Hejun Liu
    • L. David Sibley
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15
  • Photoreceptor proteins utilise biological chromophores to regulate a large range of cellular processes in response to light. Here the authors identify and characterise a sub-family of multi-centre photoreceptors, termed photocobilins, that not only utilise B12 but also contain biliverdin (BV) as an additional chromophore.

    • Shaowei Zhang
    • Laura N. Jeffreys
    • Nigel S. Scrutton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • The APC/C is a large multiprotein complex that functions as an E3 ubiquitin ligase to regulate the cell cycle. Here, the entire APC/C complex is reconstituted, and in combination with structural studies a pseudo-atomic model for 70% of the complex is provided. These results contribute towards a molecular understanding of the roles of individual subunits in APC/C assembly and their interactions with co-activators, substrates and regulatory proteins.

    • Anne Schreiber
    • Florian Stengel
    • David Barford
    Research
    Nature
    Volume: 470, P: 227-232
  • Arrigoni et al. present non-canonical voltage-gated ion channel pore domain (PD) structures demonstrating that the PD is an autonomously folded unit found in diverse proteins and show that PDs can adopt non-canonical forms in full-length channels.

    • Cristina Arrigoni
    • Marco Lolicato
    • Daniel L. Minor Jr.
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 537-548
  • Rules that allow the design of strongly funnelled protein folding energy landscapes by relating secondary structure patterns to protein tertiary motifs are used to produce ideal protein structures stabilized by completely consistent local and non-local interactions.

    • Nobuyasu Koga
    • Rie Tatsumi-Koga
    • David Baker
    Research
    Nature
    Volume: 491, P: 222-227
  • CarH is a bacterial B12-binding photoreceptor involved in transcriptional regulation. Here, the authors provide insights into B12 dynamics and associated cobalt redox changes following light activation. These demonstrate the CarH response integrates light and oxygen sensing.

    • Harshwardhan Poddar
    • Ronald Rios-Santacruz
    • David Leys
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • Nebulized mRNA delivery has broad therapeutic potential but has proven challenging. Here, the authors report on a modified lipid nanoparticle with improved conditions to allow nebulization and demonstrate its application for delivering mRNA to the lungs.

    • Allen Y. Jiang
    • Jacob Witten
    • Daniel G. Anderson
    Research
    Nature Nanotechnology
    Volume: 19, P: 364-375
  • In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

    • Dinesh Aggarwal
    • Ben Warne
    • Ian G. Goodfellow
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16
  • The condensation of RNA polymerase II (Pol II) into transcriptionally active clusters is critical for eukaryotic gene regulation and pre-mRNA transcription. Here the authors show that a tight network of tyrosine-proline interactions imparts temperature and concentration-dependent self-coacervation of Pol II’s C-terminal domain (CTD).

    • David Flores-Solis
    • Irina P. Lushpinskaia
    • Markus Zweckstetter
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141
  • Stereochemistry can affect the reactivity and transport properties of small molecules; however, it is unclear whether the stereochemistry of components in a lipid nanoparticle influences its activity in vivo. Now, it has been shown that lipid nanoparticles made with a stereopure component can increase delivery of mRNA. A biological mechanism driving the effect is also proposed.

    • Marine Z. C. Hatit
    • Curtis N. Dobrowolski
    • James E. Dahlman
    Research
    Nature Chemistry
    Volume: 15, P: 508-515
  • The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

    • Brian J. Willett
    • Joe Grove
    • Emma C. Thomson
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 1161-1179
  • The folding of outer membrane proteins (OMPs) is catalyzed by the βbarrel assembly machinery (BAM). Here, structural and functional analyses of BAM stabilized in distinct conformations elucidate the roles of lateral gate opening and interactions of BAM with the lipid bilayer in OMP assembly.

    • Paul White
    • Samuel F. Haysom
    • Sheena E. Radford
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13
  • Crystal structures of human O-GlcNAc hydrolase (hOGA) fragments show that hOGA's dimeric structure is organized by swapping of an α-helical element and reveal features of inhibitor binding to the catalytic domain.

    • Christian Roth
    • Sherry Chan
    • Gideon J Davies
    Research
    Nature Chemical Biology
    Volume: 13, P: 610-612
  • Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-mediated depolymerization of actin, which is required to recruit ESCRT-III and complete abscission.

    • Stéphane Frémont
    • Hussein Hammich
    • Arnaud Echard
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16