Nature Search

Growth hormone treatment induces mammary gland hyperplasia in aging primates

Siu T. Ng
Jian Zhou
Carolyn A. Bondy
Research01 Oct 1997
Nature Medicine

Volume: 3, P: 1141-1144
Mechanisms of Disease: using genetically altered mice to study concepts of type 2 diabetes

This article describes recent findings from genetically engineered murine models of type 2 diabetes, particularly those giving insight into defects in insulin's actions and the relationship between insulin resistance and impaired β-cell function. These models have the potential to examine specific molecular mechanisms that combine to cause diabetes in humans.

Derek LeRoith
Domenico Accili
Reviews22 Jan 2008
Nature Clinical Practice Endocrinology & Metabolism

Volume: 4, P: 164-172
Mechanisms of Disease: metabolic effects of growth hormone and insulin-like growth factor 1

Insulin-like growth factor 1 is a major effector of growth hormone. IGF1 binds the IGF1 receptor with high affinity and the insulin receptor with lower affinity. IGF1 has actions distinct from growth hormone in carbohydrate, lipid and protein metabolism; it can lower blood glucose levels and might prove efficacious for diabetes.

Derek LeRoith
Shoshana Yakar
Reviews01 Mar 2007
Nature Clinical Practice Endocrinology & Metabolism

Volume: 3, P: 302-310
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

Hiroshi Inoue
Wataru Ogawa
Masato Kasuga
Research11 Jan 2004
Nature Medicine

Volume: 10, P: 168-174
PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells

Hong Zhao
Joelle Dupont
Derek LeRoith
Research22 Jan 2004
Oncogene

Volume: 23, P: 786-794
Regulation of low-density lipoprotein receptor expression in triple negative breast cancer by EGFR-MAPK signaling

Tiffany Scully
Nathan Kase
Derek LeRoith
ResearchOpen Access09 Sept 2021
Scientific Reports

Volume: 11, P: 1-13
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation

R Novosyadlyy
A Vijayakumar
D LeRoith
Research20 Jul 2009
Oncogene

Volume: 28, P: 3477-3486
Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression

Z Zelenko
E J Gallagher
D LeRoith
Research29 Aug 2016
Oncogene

Volume: 36, P: 1394-1403
Hyperinsulinaemia in cancer

This Review discusses the current understanding of how insulin and insulin receptor signalling contribute to cancer growth, in the context of the rising prevalence of obesity and diabetes worldwide and the realization that hyperinsulinaemia may contribute to therapeutic failures.

Emily J. Gallagher
Derek LeRoith
Reviews09 Sept 2020
Nature Reviews Cancer

Volume: 20, P: 629-644
New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut

Xiaoling Qiang
Anthony S. Liotta
Jesse Roth
ResearchOpen Access13 Nov 2017
npj Biofilms and Microbiomes

Volume: 3, P: 1-11
Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model

N Alikhani
R D Ferguson
D LeRoith
Research02 Apr 2012
Oncogene

Volume: 32, P: 961-967
Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum

R Novosyadlyy
N Kurshan
D LeRoith
Research25 Apr 2008
Cell Death & Differentiation

Volume: 15, P: 1304-1317
Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

E J Gallagher
Y Fierz
D LeRoith
Research31 Oct 2011
Oncogene

Volume: 31, P: 3213-3222
Distinct cord blood C-peptide, adipokine, and lipidomic signatures by in utero HIV exposure

Jennifer Jao
Lauren C. Balmert
Irwin J. Kurland
Research26 Aug 2021
Pediatric Research

Volume: 92, P: 233-241

Search

Growth hormone treatment induces mammary gland hyperplasia in aging primates

Mechanisms of Disease: using genetically altered mice to study concepts of type 2 diabetes

Mechanisms of Disease: metabolic effects of growth hormone and insulin-like growth factor 1

Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells

Regulation of low-density lipoprotein receptor expression in triple negative breast cancer by EGFR-MAPK signaling

Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation

Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression

Hyperinsulinaemia in cancer

New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut

Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model

Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum

Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

Distinct cord blood C-peptide, adipokine, and lipidomic signatures by in utero HIV exposure

Search

Quick links

Search

Filter By:

Search

Quick links