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Showing 1–11 of 11 results
Advanced filters: Author: Devin E. Gibbs Clear advanced filters

  • Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

    • Krista Freimann
    • Anneke Brümmer
    • Kaur Alasoo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The circadian clock affects immune responses, but its role in influenza infection is not well understood. Here, Sengupta et al. show that time of infection and the circadian clock have no effect on lung virus titers, but affect inflammation, morbidity and mortality.

    • Shaon Sengupta
    • Soon Y. Tang
    • Garret A. FitzGerald
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • An analysis of human chromosome 15 — which is altered in Prader-Willi and Angelman syndromes — reveals that it resembles a hall of mirrors, as it contains a number of sequence duplications throughout its length. The evolutionary events that may have led to the high number of duplications was also reconstructed.

    • Michael C. Zody
    • Manuel Garber
    • Chad Nusbaum
    Research
    Nature
    Volume: 440, P: 671-675

  • The genome of the gibbon, a tree-dwelling ape from Asia positioned between Old World monkeys and the great apes, is presented, providing insights into the evolutionary history of gibbon species and their accelerated karyotypes, as well as evidence for selection of genes such as those for forelimb development and connective tissue that may be important for locomotion through trees.

    • Lucia Carbone
    • R. Alan Harris
    • Richard A. Gibbs
    ResearchOpen Access
    Nature
    Volume: 513, P: 195-201

  • A one-kilometre-resolution map of aboveground carbon accumulation rates of forest regrowth shows 100-fold variation across the globe, with rates 32% higher on average than IPCC estimates.

    • Susan C. Cook-Patton
    • Sara M. Leavitt
    • Bronson W. Griscom
    Research
    Nature
    Volume: 585, P: 545-550

  • With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

    • Roger McLendon
    • Allan Friedman
    • Elizabeth Thomson
    Research
    Nature
    Volume: 455, P: 1061-1068

  • The genome of the southeast Asian orang-utan has been sequenced. The draft assembly of a Sumatran individual alongside sequence data from five Sumatran and five Bornean orang-utan genomes is presented. The resources and analyses described offer new opportunities in evolutionary genomics, insights into hominid biology, and an extensive database of variation for conservation efforts.

    • Devin P. Locke
    • LaDeana W. Hillier
    • Richard K. Wilson
    ResearchOpen Access
    Nature
    Volume: 469, P: 529-533