The sialic acid–dependent interaction of the co-inhibitory receptors CD24 and SiglecG prevents excessive inflammatory responses to pathogen infection. Chen et al. show that microbial sialidases exacerbate sepsis by disrupting this interaction and that sialidase inhibitors reduce mortality in an intestinal perforation mouse model of sepsis.
- Guo-Yun Chen
- Xi Chen
- Yang Liu
