Search

La₅Ni₃O₁₁, a hybrid Ruddlesden–Popper nickelate, exhibits pressure-induced superconductivity with a high superconducting volume fraction. It offers insights into the interplay of structure and electronic order in nickelate superconductors.

At equilibrium, the ferroelectric polarization is proportional to the strain. At ultrafast timescales, an above-bandgap laser excitation decouples strain and polarization, which, out of equilibrium, is mainly determined by the photoexcited electrons.

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Nitrogen and phosphorus limitations are both key to spatial patterns and temporal trends in primary production. This global analysis indicates that phosphorus limitation on terrestrial primary productivity has become stronger and is increasing more rapidly than nitrogen limitation.

3D visualisation of nano-scale crystals using X-ray ptychography shows that the aggregation of nanolites can increase magma viscosity, increasing the potential of magma fragmentation and a highly explosive volcanic eruption

Efficient electro-optic conversion is central to photonic computing, and thin-film lithium niobate (TFLN) offers this capability. Here, the authors demonstrate computing circuits on the TFLN platform, enabling the next generation of photonic computing systems featuring both high-speed and low-power.

Using polarimetric satellite data, the authors quantify the global impact of cloud droplet distribution changes on aerosol–cloud interactions and introduce a parameterization to enhance climate model performance.

Tumor-associated neutrophils exhibit heterogeneity in breast cancer. Here, the authors identify a distinct precursor population (PreNeu) in estrogen receptor-positive tumors. PreNeu suppress homologous recombination in cancer cells, promoting error-prone DNA repair and enhancing sensitivity to PARP inhibitors.

Four cosmologists discuss the prospects for the concordance cosmological model — made up of 70% dark energy in the form of a cosmological constant Λ, 25% cold dark matter and 5% baryonic matter in the present day — in the light of multiple tensions between existing datasets.

Cardiomyopathies are linked to dysregulated gene expression. Here, the authors identify the human long noncoding RNA HSCHARME as a disease-associated regulator of cardiomyocyte differentiation, acting through alternative splicing control.

The authors demonstrate deeply subwavelength light confinement in the terahertz spectral range by exploiting the strong light–matter coupling and hyperbolicity of phonon polaritons in hafnium-based dichalcogenides.

Craniofacial development and structure in early Pleistocene Homo is unclear due to a lack of well-preserved specimens. Here, the authors examine infant craniofacial fossils from eastern and southern Africa to demonstrate that taxonomic diversity in early Homo is already present very early in life.

Metastasis of pancreatic cancer has been associated with epithelial-mesenchymal transition (EMT). Here, the authors identify STN1 as a regulator of pancreatic cancer metastasis by promoting transcription of EMT-activator ZEB1, which is independent of its known role in telomere maintenance.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

The Fermi-LAT Collaboration reports a significant γ-ray detection (5.2σ) from the coronae of radio-quiet active galactic nuclei, revealing compact (~10 gravitational radii) and extended (~2.7 × 10⁶ gravitational radii) corona regions, challenging existing models.

Using the well-established foundry-based lithium niobate nanophotonics platform, a general electro-optic digital-to-analogue link with ultrahigh bandwidth (>150 Gb s⁻¹) and ultralow power consumption (0.058 pJ b⁻¹) is demonstrated, providing a direct, energy-efficient, high-speed and scalable solution for interfacing digital electronics and photonics.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Integrating CO₂ capture and electrochemical conversion may lower energy consumption relative to the separated processes, but scale-up is limited by low carbon conversion and energy-intensive solvent regeneration. Now, research shows that piperazine, alongside a Ni single-atom catalyst, allows effective, stable CO₂ capture, and conversion to CO in a low-energy process.

Engineering mammalian cells with synthetic circuits drives innovation in next-generation biotherapeutics and industrial biotechnology. Here the authors use RNA-seq and computational biology to identify drugs that increase engineered cell productivity without genetic edits - Filgotinib proved enhanced gene expression across contexts, offering a powerful tool for biotech applications.

This study introduces a sustainable light-driven method for forming C(sp³)–C(sp³) bonds using carbon nitride and nickel catalysts, offering an efficient, iridium-free alternative for pharmaceutical synthesis with broad applicability and recyclability.

Fusarium crown rot disease threatens wheat yields. Here, the authors report roles for wheat TaSnRK1α and a catalase antioxidant enzyme in mediating Fusarium crown rot resistance by scavenging reactive oxygen species in wheat plants.

Dual implementation of climate mitigation and adaptation policies in Chinese cities significantly enhances low-carbon resilience, particularly under extreme weather, through green innovation, human capital and infrastructure. This integrated approach offers a model for urban climate governance, emphasizing co-benefits and tailored strategies for diverse city types.

In the final analysis of a phase 1/phase 2 trial of autologous GD2-targeting CAR T cells in pediatric patients with high-risk metastatic, relapsed or refractory neuroblastoma, treatment was overall well tolerated, with an objective response rate of 66%. These findings were further supported by a case series involving the same therapy in a similar patient population.

The spontaneous emergence of autocatalytic RNAs is central to origin of life. Here, the authors use machine learning, high-throughput screening and statistical physics to explore large neutral space of catalytic RNAs.

Edge states of QSHIs hold promise for future technologies due to protection against backscattering. This work observes that intraband backscattering remains allowed for nonmonotonic edge bands, revealing critical aspects of edge state stability.

The composition of Earth’s inner core can be constrained by the supercooling required for its formation. Based on molecular dynamic simulations this work shows that inner core nucleation from an iron-carbon composition fits geophysical constraints.

Underplating and magmatic additions to thinning continental crust by Afar plume–driven asthenospheric melts delayed the onset of seafloor spreading during early Red Sea rifting.

Qiao et al. report the design and characterization of an optogenetic platform for the dynamic control of protein expression and secretion by engineered bacteria, with implications for cancer therapy.

Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are uncommon mesenchymal neoplasms with limited treatment options. Here, the authors perform a multi-omics analysis of 189 cases of CNS SFTs to identify potential clinical biomarkers and therapeutic targets.

Scientists, research institutions, funders, libraries and publishers must all improve software practices.

Natural products have historically made a major contribution to pharmacotherapy, but also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization. This Review discusses recent technological developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — that are enabling a revitalization of natural product-based drug discovery.

Protein sequences from fossil tooth enamel of a rhinocerotid from Canada’s High Arctic are used to develop phylogenetic frameworks from a specimen too old to preserve ancient DNA.

An electrically driven perovskite laser is constructed by vertically integrating a low-threshold single-crystal perovskite microcavity sub-unit with a high-power microcavity perovskite LED sub-unit.

A global land surface phenology map predicts complex geographical discontinuities in flowering phenology, genetic divergence and harvest seasonality across a range of taxa.

Understanding brain function requires integrating neuronal structure, activity, and genes. Here, authors developed an optogenetic tool they name Pisces, to enable complete labeling of individual neurons’ morphology with functional and molecular profiling, allowing multimodal single-cell analysis in vivo in zebrafish.

Native mass spectrometry can be combined with lipidomic experiments to determine the structural and functional lipids of receptor and transporter assemblies. This protocol describes how to use initial native mass spectrometry results to guide experimental design.

Gapless modes emerging from non-equilibrium phase transitions are predicted to diffuse rather than propagate as sound waves. Now, the diffusion of these modes and their suppression under symmetry breaking are confirmed in a polariton condensate.

The Perseverance rover detected polycyclic aromatic hydrocarbons preserved within sulfates in the fan and floor of Jezero crater on Mars, offering new insights into past habitability and the preservation of organic matter on Mars.

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

Atomically dispersed metal atoms on semiconductor surfaces alter the local surface carrier distribution. Here, the authors demonstrate the improvement of the SERS activity of titanate nanotubes by controllable loading with monoatomic W species.

The authors find low-energy magnetic excitations and a flat band near the Fermi level in kagome metal superconductor CsCr3Sb5 by angle-resolved photoemission and resonant inelastic X-ray scattering. They suggest that the flat band plays a role in the emergence of charge/magnetic order at low temperatures.

An analysis of the EPIC study demonstrates that dietary plant biodiversity presents benefits for human and planetary health, but adverse environmental impacts are associated with dietary animal species richness.