Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–13 of 13 results
Advanced filters: Author: Dick de Zeeuw Clear advanced filters
  • Cardiovascular mortality and morbidity remain high despite a variety of therapies being available. New avenues for therapy are, therefore, continually sought. Here, whether the relationship that exists between cardiovascular and renal disease could provide such an opportunity is discussed, in the context of treatment strategies directed at the renin–angiotensin–aldosterone system.

    • Dick de Zeeuw
    Research
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 5, P: S27-S35
  • The definition of this syndrome, its utility as a predictor of cardiovascular risk, and the treatment implications of diagnosis remain unsettled. In this Article, de Zeeuw and Bakker argue that, while the most commonly used definitions of the metabolic syndrome perform poorly in estimatation of cardiovascular risk, the concept is nonetheless useful.

    • Dick de Zeeuw
    • Stephan JL Bakker
    Research
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 5, P: S10-S14
  • Albuminuria is used as a marker of kidney disease progression, but whether it has a role in the pathogenesis of kidney disease and the reasons for its association with cardiovascular disease are unclear. In this Review, Rabelink and de Zeeuw propose that degradation of the glycocalyx leads to albuminuria and that the filtered protein contributes to kidney disease pathogenesis. Furthermore, they discuss how systemic degradation of the gylcocalyx can lead to cardiovascular disease, providing an explanation for the association between these diseases and albuminuria.

    • Ton J. Rabelink
    • Dick de Zeeuw
    Reviews
    Nature Reviews Nephrology
    Volume: 11, P: 667-676
  • Results from the ROADMAP trial have highlighted the discrepancy between the renoprotective effects of olmesartan treatment in patients with type 2 diabetes mellitus, and the observed increase in cardiovascular deaths. Several explanations for these results need to be considered, which may influence future clinical practice.

    • Sara S. Roscioni
    • Hiddo J. Lambers Heerspink
    • Dick de Zeeuw
    News & Views
    Nature Reviews Nephrology
    Volume: 7, P: 427-428
  • Makani and colleagues report that dual blockade of the renin–angiotensin–aldosterone system is associated with harm despite previous studies showing that this approach decreases blood pressure and albuminuria. Do these results imply that we should abandon surrogate markers? Or should we become more creative in using them?

    • Hiddo J. Lambers Heerspink
    • Dick de Zeeuw
    News & Views
    Nature Reviews Endocrinology
    Volume: 9, P: 261-263
  • Defining the dose of a new renoprotective drug with the optimal benefit-to-risk ratio is an important consideration for drug developers and physicians. Have we learned from past experiences?

    • Hiddo Lambers Heerspink
    • Dick de Zeeuw
    News & Views
    Nature Reviews Nephrology
    Volume: 5, P: 498-500
  • In diabetic nephropathy, excessive activation of the renin–angiotensin–aldosterone system (RAAS) results in progressive renal damage. Here, the authors discuss the efficacy of RAAS blockade for the prevention of disease progression and the mechanisms of renal protection. They also highlight new strategies aimed at optimizing RAAS blockade and improving outcomes in patients with diabetic nephropathy.

    • Sara S. Roscioni
    • Hiddo J. Lambers Heerspink
    • Dick de Zeeuw
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 77-87
  • Bicaudal-D is an evolutionary conserved dynein adaptor protein, and missense mutations in this protein are associated with spinal muscular atrophy (SMA). Here, Jaarsma et al.show that Bicaudal-D also plays an essential role in controlling neuronal migration and lamination in the developing mouse cerebellum.

    • Dick Jaarsma
    • Robert van den Berg
    • Casper C. Hoogenraad
    Research
    Nature Communications
    Volume: 5, P: 1-13
  • Mineralocorticoid-receptor antagonists (MRAs) effectively reduce blood pressure and albuminuria in patients with chronic kidney disease who experience aldosterone breakthrough. Use of MRAs is limited, however, by the occurrence of hyperkalaemia, which frequently develops in patients with impaired kidney function, and/or diabetes. This Review discusses potential approaches to identify patients who are particularly prone to developing hyperkalaemia with MRA therapy and describes currently available and promising strategies to prevent and control hyperkalaemia in patients with CKD.

    • Sara S. Roscioni
    • Dick de Zeeuw
    • Hiddo J. Lambers Heerspink
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 691-699