Nature Search

Plasma proteomics links brain and immune system aging with healthspan and longevity

In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity.

Hamilton Se-Hwee Oh
Yann Le Guen
Tony Wyss-Coray
ResearchOpen Access09 Jul 2025
Nature Medicine

Volume: 31, P: 2703-2711
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease

The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals with early Alzheimer’s disease harboring amyloid and tau pathology.

Hamilton Se-Hwee Oh
Deniz Yagmur Urey
Tony Wyss-Coray
ResearchOpen Access31 Mar 2025
Nature Medicine

Volume: 31, P: 1592-1603
Publisher Correction: Dysregulation of brain and choroid plexus cell types in severe COVID-19

Andrew C. Yang
Fabian Kern
Tony Wyss-Coray
Amendments and Corrections08 Oct 2021
Nature

Volume: 598, P: E4
A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

Neurodegenerative diseases are linked to changes in the immune system and inflammation. Here, the authors studied immune cells from healthy individuals and neurodegenerative diseases and identified sex-specific disease-associated changes.

Friederike Grandke
Tobias Fehlmann
Andreas Keller
ResearchOpen Access25 Feb 2025
Nature Communications

Volume: 16, P: 1-13
Organ aging signatures in the plasma proteome track health and disease

Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and aging effects using plasma proteomics.

Hamilton Se-Hwee Oh
Jarod Rutledge
Tony Wyss-Coray
ResearchOpen Access06 Dec 2023
Nature

Volume: 624, P: 164-172
Dysregulation of brain and choroid plexus cell types in severe COVID-19

Single-nucleus transcriptomes of frontal cortex and choroid plexus samples from patients with COVID-19 reveal pathological cell states that are similar to those associated with human neurodegenerative diseases and chronic brain disorders.

Andrew C. Yang
Fabian Kern
Tony Wyss-Coray
Research21 Jun 2021
Nature

Volume: 595, P: 565-571
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

An integrated analysis of several cohorts shows that clonal, antigen-experienced T cells are found in the cerebrospinal fluid of patients with Alzheimer’s disease, suggesting that the adaptive immune system has a role in age-related neurodegeneration.

David Gate
Naresha Saligrama
Tony Wyss-Coray
Research08 Jan 2020
Nature

Volume: 577, P: 399-404
Parkinson’s disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction

Edward N. Wilson
Jacob Umans
Katrin I. Andreasson
ResearchOpen Access26 Apr 2025
npj Parkinson's Disease

Volume: 11, P: 1-13

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