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Showing 1–2 of 2 results
Advanced filters: Author: Dominik Loiero Clear advanced filters

  • Immune checkpoint blockade (ICB) has shown promising activity in patients with advanced endometrial cancer, however its potential in the context of loco-regional disease remains unclear. Here the authors report the results of a phase I trial of neoadjuvant pembrolizumab (anti-PD1) in patients with mismatch repair deficient resectable endometrial cancer.

    • Anneke L. Eerkens
    • Koen Brummel
    • Hans W. Nijman
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Tertiary lymphoid structures (TLS) are associated with a reduced risk of cancer recurrence and improved response to immune checkpoint blockade in several tumor types. Here the authors identify L1CAM as a marker for mature TLS and show that the presence of TLS is associated with favorable prognosis in patients with endometrial cancer from the PORTEC-3 trial.

    • Nanda Horeweg
    • Hagma H. Workel
    • Marco de Bruyn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10