Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Dominik Witzigmann Clear advanced filters

  • Long-circulating, transfection-competent LNP-mRNA systems are key for effective extrahepatic delivery. Here, authors show that LNPs with high bilayer lipid ratios yield high mRNA encapsulation, prolonged circulation, and enhanced transfection in extrahepatic tissues.

    • Miffy Hok Yan Cheng
    • Yao Zhang
    • Pieter R. Cullis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • This Review provides an overview of four platform technologies that are currently used in the clinic for delivery of nucleic acid therapeutics, describing their properties, discussing technical advancements that led to clinical approval, and highlighting examples of approved genetic drugs that make use of these technologies.

    • Jayesh A. Kulkarni
    • Dominik Witzigmann
    • Roy van der Meel
    Reviews
    Nature Nanotechnology
    Volume: 16, P: 630-643

  • The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves the way for clinical development of many nucleic acid-based therapies enabled by nanoparticle delivery.

    • Akin Akinc
    • Martin A. Maier
    • Pieter R. Cullis
    Comments & Opinion
    Nature Nanotechnology
    Volume: 14, P: 1084-1087