VVD-133214, a clinical-stage, covalent allosteric inhibitor of the helicase WRN, was well tolerated in mice and led to robust tumour regression in multiple microsatellite-instability-high colorectal cancer cell lines and patient-derived xenograft models.
- Kristen A. Baltgalvis
- Kelsey N. Lamb
- Todd M. Kinsella
