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Showing 1–6 of 6 results
Advanced filters: Author: Dorothee Speck Clear advanced filters
  • Rhodococcus equiis an animal pathogen that sometimes causes opportunistic infections in immunocompromised patients. Speck et al. present the case of a 62-year-old male renal transplant recipient who presented with fever, hemoptysis and left-sided pleuritic chest pain. After numerous investigations, a diagnosis of R. equi infection with bacteremic pleuropneumonia and pseudotumor was made. This Case Study describes the diagnosis and management of R. equiinfection, which has a very varied clinical presentation in humans.

    • Dorothee Speck
    • Irene Koneth
    • Isabelle Binet
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 4, P: 398-403
  • This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet and infections, and host-intrinsic factors, such as the activity of microglial cells and other immune, vascular and neuronal cell populations, on disease development. They also highlight emerging drugs that target this inflammatory component for therapy of Alzheimer disease.

    • Michael T. Heneka
    • Wiesje M. van der Flier
    • Sean-Patrick Riechers
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 321-352
  • Evidence is accumulating that both central and peripheral immune responses are dysregulated in Alzheimer disease (AD). This roadmap reviews the current status of this research and provides a new research prospectus to advance our understanding of peripheral–central immune crosstalk in AD.

    • Brianne M. Bettcher
    • Malú G. Tansey
    • Michael T. Heneka
    Reviews
    Nature Reviews Neurology
    Volume: 17, P: 689-701