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Showing 1–8 of 8 results
Advanced filters: Author: Duncan S Van Nest Clear advanced filters
  • Protein kinase A (PKA) is a cyclic nucleotide dependent protein kinase. Here the authors use single molecule optical tweezers and steered molecular dynamic simulations to follow in real time and quantitatively characterize the signals transduced by cAMP through the structure of the PKA regulatory subunit, and propose a model for PKA allosteric activation.

    • Yuxin Hao
    • Jeneffer P. England
    • Rodrigo A. Maillard
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12
  • Academics are increasingly calling for and asked to, work in interdisciplinary teams to address pressing social-ecological challenges. However, there are significant barriers to pursuing interdisciplinary collaborations within current university structures. Taking the first two years of our Centre for Unusual Collaborations (CUCo) as a case study of setting up a space for exploration and experimentation, we discuss how unusual interdisciplinary collaborations had unexpected effects, beyond the potential for societal impact. Most surprisingly, we found the CUCo model offered a welcome opportunity to break away from the productivism and competition that is common in academia while stimulating exploration of our own disciplines. This often led to an expansion of ideas and deepened understanding in ways that sparked joy, curiosity, creativity and meaning. We discuss how academic culture currently hampers collaboration: key roadblocks are identified, specifically rewards and recognition, the lack of spaces for trust-building, and competence and skills that are not geared towards collaboration. We present lessons learned in overcoming roadblocks to stimulate research across disciplinary lines and explain how unusual interdisciplinary collaborations provide opportunities for opening and deepening research lines, and how they can be fun and meaningful. We argue that, at a moment when academia faces growing rates of burnout and stress, such collaborations are fundamental.

    • C. Lamain
    • S. Brugman
    • J. Duncan
    Comments & OpinionOpen Access
    Humanities and Social Sciences Communications
    Volume: 11, P: 1-7