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Showing 1–50 of 103 results
Advanced filters: Author: Dustin C. Brown Clear advanced filters
  • This study reveals disparities in Superfund site exposure among vulnerable US communities and introduces metrics and an action priority matrix to guide equitable and targeted cleanup efforts.

    • Mohammed Azhar
    • Farshid Vahedifard
    • Kaveh Madani
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • The Middle Palaeolithic of southwest Asia witnessed interactions and knowledge sharing between archaic and modern humans ~130,000–80,000 years ago. These interactions led to increased behavioural complexity and consolidation of a uniform behavioural set across Homo groups in the region.

    • Yossi Zaidner
    • Marion Prévost
    • Israel Hershkovitz
    ResearchOpen Access
    Nature Human Behaviour
    Volume: 9, P: 886-901
  • Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis involving evasion of immune control. Here, the authors perform a comprehensive analysis of single-cell multi-omic data revealing either a myeloid-enriched or adaptive-enriched tumour microenvironment, linked to distinct B and T cell clonal selection and differentiation, distinct overall survival, and potential therapeutic approaches.

    • Shivan Sivakumar
    • Ashwin Jainarayanan
    • Rachael Bashford-Rogers
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor signalling - which could be targeted with MEK/EGFR inhibitors.

    • Dustin J. Flanagan
    • Raheleh Amirkhah
    • Owen J. Sansom
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18
  • The adhesion receptor CD2 plays an important role in the full activation of T cells. Dustin and colleagues show that CD2 occupies a region in the periphery of the immunological synapse where it amplifies cognate antigen signals, whereas the presence of PD-1 disrupts this effect.

    • Philippos Demetriou
    • Enas Abu-Shah
    • Michael L. Dustin
    Research
    Nature Immunology
    Volume: 21, P: 1232-1243
  • Analysing data on egg size and planktonic duration from >750 marine species with a larval period, the authors show that temperature, life-history and oceanographic processes interact to shape peaks of dispersal at low and high latitudes.

    • Mariana Álvarez-Noriega
    • Scott C. Burgess
    • Dustin J. Marshall
    Research
    Nature Ecology & Evolution
    Volume: 4, P: 1196-1203
  • Lorlatinib—a ROS1/ALK inhibitor—is currently undergoing clinical trials for the treatment of non-small cell lung cancers. Here the authors develop synthetic routes to11C- and 18F-labelled lorlatinib, with subsequent PET imaging showing good blood brain barrier permeability in non-human primates.

    • Thomas Lee Collier
    • Marc D. Normandin
    • Neil Vasdev
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12
  • T cells communicate with antigen-presenting cells (APC) via the signaling crosstalk at the immunological synapse (IS). Here the authors use bead-supported lipid bilayers as synthetic APCs to find that trans-synaptic vesicles produced by T cells in the IS carry specialized cargos distinct from constitutive extracellular vesicles to serve as intercellular messengers.

    • Pablo F. Céspedes
    • Ashwin Jainarayanan
    • Michael L. Dustin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18
  • The lysosomal enzyme beta-glucocerebrosidase is a key player and promising therapeutic target in Parkinson’s disease. Here, Dobert et al. leveraged cryo-EM to solve the protein structure of the enzyme in complex with its lysosomal transporter LIMP-2.

    • Jan Philipp Dobert
    • Jan-Hannes Schäfer
    • Philipp Arnold
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • FXR regulates the levels of ACE2 in tissues of the respiratory and gastrointestinal systems that are affected by COVID-19, and inhibiting FXR with ursodeoxycholic acid downregulates ACE2 and reduces susceptibility to SARS-CoV-2 infection.

    • Teresa Brevini
    • Mailis Maes
    • Fotios Sampaziotis
    ResearchOpen Access
    Nature
    Volume: 615, P: 134-142
  • Authors report that long-term intestinal tissue maintenance in naked mole rats is achieved by having an expanded pool of slow-dividing adult stem cells while a higher proportion of differentiated cells confer enhanced function and protection to the intestinal mucosa.

    • Shamir Montazid
    • Sheila Bandyopadhyay
    • Shazia Irshad
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20
  • Structures of the bifunctional heme transporter cytochrome c synthase CcsBA in closed and open states show how heme binding in the periplasmic site induces a conformational shift, exposing the heme and facilitating its transfer to apocytochrome c.

    • Deanna L. Mendez
    • Ethan P. Lowder
    • Robert G. Kranz
    Research
    Nature Chemical Biology
    Volume: 18, P: 101-108
  • Living in a harsh environment is linked to breeding in cooperative groups, but which is cause and which is effect? Here, a bird phylogeny is used to show that, contrary to previous assumption, cooperative breeders are more likely to colonize harsh environments.

    • Charlie K. Cornwallis
    • Carlos A. Botero
    • Ashleigh S. Griffin
    Research
    Nature Ecology & Evolution
    Volume: 1, P: 1-10
  • The epithelial protein Coxsackievirus Adenovirus Receptor (CAR) is a virus receptor but may have other functions. Here the authors show that deletion of CAR in mice leads to reduced house dust mite-induced lung inflammation, reduced neutrophil accumulation and alterations in airway remodelling.

    • Elena Ortiz-Zapater
    • Dustin C. Bagley
    • Maddy Parsons
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19
  • A family of calcium-dependent protein kinases (CDPK) is present in apicomplexan parasites but not in animals, indicating their potential as targets for anti-parasitic drugs. Structural and functional studies on Toxoplasma gondii CDPK1 now reveal that this kinase is sensitive to a class of drugs called bumped kinase inhibitors, which can inhibit the parasite's growth and host cell invasion.

    • Kayode K Ojo
    • Eric T Larson
    • Wesley C Van Voorhis
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 602-607
  • A new protein engineering approach inserts metal-coordination motifs to stabilize natural protein interfaces while other favorable contacts are removed, yielding metal-inducible protein-protein interactions that have allowed the study of a self-assembling protein cage and the chemical labeling of its interior.

    • Dustin J E Huard
    • Kathleen M Kane
    • F Akif Tezcan
    Research
    Nature Chemical Biology
    Volume: 9, P: 169-176
  • Stretchable displays need stretchable electronics to control them. Here, the authors create transparent and deformable thin-film transistors comprised of silver nanowire-based electrodes, a carbon nanotube network channel and a polyurethane-co-polyethylene oxide dielectric made using solution-based techniques.

    • Jiajie Liang
    • Lu Li
    • Qibing Pei
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10
  • Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

    • Michael E. Dunn
    • Aaron Kithcart
    • Lori Morton
    ResearchOpen Access
    Nature
    Volume: 633, P: 654-661
  • Cryo-EM and biochemical analyses reveal that centromere-associated protein CENP-N promotes centromere-specific nucleosome stacking and higher order structures in vitro and in the cell.

    • Keda Zhou
    • Magdalena Gebala
    • Karolin Luger
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 403-413
  • The tumour suppressor RUNX1 is often lost or mutated in oestrogen receptor-positive breast cancers. In this study, the authors demonstrate that the loss of RUNX1 unleashes oestrogen-mediated inhibition of AXIN1, a negative regulator of β-catenin, resulting in β-catenin signalling-mediated cancer cell proliferation and mitosis deregulation.

    • Nyam-Osor Chimge
    • Gillian H. Little
    • Baruch Frenkel
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12
  • Individual variation in fMRI-derived brain networks is reproduced in a model using only the smoothness (autocorrelation) of the fMRI time series. Smoothness has implication for aging and can be causally manipulated by psychedelic serotonergic drugs.

    • Maxwell Shinn
    • Amber Hu
    • John D. Murray
    Research
    Nature Neuroscience
    Volume: 26, P: 867-878
  • Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B.

    • Bonnie van Wilgenburg
    • Iris Scherwitzl
    • Paul Klenerman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11
  • Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and inflammation induce the development of colonic tumours with a foetal-like phenotype.

    • Joshua D. G. Leach
    • Nikola Vlahov
    • Owen J. Sansom
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15
  • The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II stimuli, providing new insight into the transcriptional regulation of vascular pathologies.

    • Sadhan Das
    • Parijat Senapati
    • Rama Natarajan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19
  • Direct observation of ionic motion in buried metal/oxide interfaces and its correlation with physical properties is a challenging task. Here, the authors observe oxygen migration in a model system with controllable positive exchange bias, due to the redox-driven formation of a ferromagnetic interfacial layer.

    • Dustin A. Gilbert
    • Justin Olamit
    • Kai Liu
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8
  • Evolutionary modelling and expert review are applied to integrate experimentally supported knowledge accumulated in the Gene Ontology knowledgebase to create a draft human gene ‘functionome’.

    • Marc Feuermann
    • Huaiyu Mi
    • Paul D. Thomas
    ResearchOpen Access
    Nature
    Volume: 640, P: 146-154
  • The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34 complexes recruitment to and activation on membranes by specific Rab GTPases.

    • Shirley Tremel
    • Yohei Ohashi
    • Roger L. Williams
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15
  • Small intestinal crypts contain twice as many effective stem cells as large intestinal crypts, and this difference is determined by the degree of Wnt-driven retrograde cell movement—which is largely absent in the large intestine—counteracting conveyor-belt-like upward movement.

    • Maria Azkanaz
    • Bernat Corominas-Murtra
    • Jacco van Rheenen
    Research
    Nature
    Volume: 607, P: 548-554
  • Nearly 17% of all bird species are hosts to obligate brood parasites like the common cuckoo. Antonson et al. show that parasite species hedge their reproductive bets by outsourcing parental care to a greater variety of host species when the rearing environment for their young is more unpredictable.

    • Nicholas D. Antonson
    • Dustin R. Rubenstein
    • Carlos A. Botero
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7
  • Human follicular helper T cells engaging in synaptic interactions with germinal centre B cells release dopamine stored in chromogranin B+ granules, causing rapid externalization of ICOS ligand, which in turn enhances CD40L delivery to the synaptic cleft and synaptic contact, and results in an accelerated response.

    • Ilenia Papa
    • David Saliba
    • Carola G. Vinuesa
    Research
    Nature
    Volume: 547, P: 318-323
  • There is currently no licensed SARS-CoV-2 vaccine. Here, the authors generate an optimized DNA vaccine candidate encoding the SARS-CoV-2 spike antigen, demonstrating induction of specific T cells and neutralizing antibody responses in mice and guinea pigs. These initial results support further development of this vaccine candidate.

    • Trevor R. F. Smith
    • Ami Patel
    • Kate E. Broderick
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • Previous studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and neuronal loss, and identifying the inflammatory components that may contribute.

    • Stephen J. Rubino
    • Lior Mayo
    • Howard L. Weiner
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13
  • A dataset of the genomes of 363 species from the Bird 10,000 Genomes Project shows increased power to detect shared and lineage-specific variation, demonstrating the importance of phylogenetically diverse taxon sampling in whole-genome sequencing.

    • Shaohong Feng
    • Josefin Stiller
    • Guojie Zhang
    Research
    Nature
    Volume: 587, P: 252-257
  • This work reveals the structural and biochemical basis for phosphorylation-dependent day/night signaling by KaiC in the cyanobacterial circadian clock.

    • Jeffrey A. Swan
    • Colby R. Sandate
    • Carrie L. Partch
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 759-766
  • Male animals are typically more elaborately ornamented than females, probably because females make more of an energetic investment in raising young. However, this generality may not apply in cooperatively breeding vertebrates, where the energetic load is similar in males and females. The socially diverse African starlings are now used to study this issue, revealing that where intrasexual competition among females may be intense, female trait elaboration is selected for.

    • Dustin R. Rubenstein
    • Irby J. Lovette
    Research
    Nature
    Volume: 462, P: 786-789
  • In nature, enzymes can orchestrate the combination of several different catalytic species, but mimicking this with synthetic catalysts is often problematic due to undesirable interactions between the catalysts. Here, an N-heterocyclic carbene and a Lewis acid cooperate to catalyse the efficient formation of γ-lactams.

    • Dustin E. A. Raup
    • Benoit Cardinal-David
    • Karl A. Scheidt
    Research
    Nature Chemistry
    Volume: 2, P: 766-771