Nature Search

Impact of midazolam vs. saline on effect size estimates in controlled trials of ketamine as a rapid-acting antidepressant

Samuel T. Wilkinson
Cristan Farmer
Carlos A. Zarate Jr.
Research17 Jan 2019
Neuropsychopharmacology

Volume: 44, P: 1233-1238
Active γ-carboxylated human factor IX expressed using recombinant DNA techniques

Henri de la Salle
Werner Altenburger
Jean-Pierre Lecocq
Research18 Jul 1985
Nature

Volume: 316, P: 268-270
Mutational landscape of triple-negative breast cancer in African American women

This study explores the genomic and transcriptomic landscapes of triple-negative breast cancer in African American women. The authors show that the mutational profile is broadly similar to that observed in European and East Asian ancestry women while highlighting some interesting differences.

Song Yao
Lei Wei
John D. Carpten
ResearchOpen Access26 Aug 2025
Nature Genetics

Volume: 57, P: 2166-2176
ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome

Clarke et al. identify chromatin factor ZNF280A, which is recruited to damaged chromatin where it promotes long-range DNA-end resection. Loss of ZNF280A is linked to genome instability in patients with 22q11.2 distal deletion syndrome.

Thomas L. Clarke
Hyo Min Cho
Raul Mostoslavsky
Research16 Jun 2025
Nature Cell Biology

Volume: 27, P: 1006-1020
Out-of-hospital births in California 1991–2011

A I Girsen
J A Mayo
M L Druzin
Research09 Nov 2017
Journal of Perinatology

Volume: 38, P: 41-45
Associations between social drivers of health and breast cancer stage at diagnosis among U.S. Black women

Mollie E. Barnard
Bo Qin
Larry Norton
ResearchOpen Access06 Aug 2025
npj Breast Cancer

Volume: 11, P: 1-9
Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis

Gustavo C. Medeiros
Todd D. Gould
Fernando S. Goes
Reviews27 Jun 2022
Molecular Psychiatry

Volume: 27, P: 3658-3669
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

PD-1 is a critical modulator of CD8⁺ T cell activation and exhaustion. Sen and colleagues show that a cell-state-specific enhancer tunes PD-1 expression exclusively in exhaustion and that deletion of this enhancer improves CD8⁺ T cell function.

Sarah A. Weiss
Amy Y. Huang
Debattama R. Sen
Research17 Sept 2024
Nature Immunology

Volume: 25, P: 1871-1883
International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators

Rebecca B. Price
Nicholas Kissel
Meredith L. Wallace
ResearchOpen Access07 Sept 2022
Molecular Psychiatry

Volume: 27, P: 5096-5112
Effects of psychoplastogens on blood levels of brain-derived neurotrophic factor (BDNF) in humans: a systematic review and meta-analysis

Abigail E. Calder
Adrian Hase
Gregor Hasler
ReviewsOpen Access29 Nov 2024
Molecular Psychiatry

Volume: 30, P: 763-776
PERIURETHRAL ANAEROBIC MICROFLORA IN UTI-PRONE AND HEALTHY GIRLS

I Bollgren
C-E Nord
J Winberg
Research01 Aug 1980
Pediatric Research

Volume: 14, P: 981
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

The causative mechanism for the immunodeficiency and autoinflammatory disease XLPDR is unknown. Burstein and colleagues show that XLPDR is caused by disruption of POLA1, which encodes a DNA polymerase subunit; this, in turn, leads to dysregulated production of type I interferons.

Petro Starokadomskyy
Terry Gemelli
Ezra Burstein
Research28 Mar 2016
Nature Immunology

Volume: 17, P: 495-504
Targeting TBK1 to overcome resistance to cancer immunotherapy

Targeting TBK1 is an effective strategy to overcome resistance to cancer immunotherapy.

Yi Sun
Or-yam Revach
Russell W. Jenkins
Research12 Jan 2023
Nature

Volume: 615, P: 158-167
Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality

Higher intake of dietary fiber and whole grains are associated with reduced risk of various diseases including some cancers. Here, the authors estimate reductions in liver cancer of 22% and 31% and chronic liver disease mortality of 56% and 63% associated with increased whole grain and dietary fiber intake, respectively.

Xing Liu
Wanshui Yang
Xuehong Zhang
ResearchOpen Access04 Nov 2021
Nature Communications

Volume: 12, P: 1-9
Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women

GWAS have enhanced our understanding for the genetic basis of breast cancer, but the majority of them were performed for European ancestry populations. Here, the authors use a cross-ancestry approach and report seven new variants associated with breast cancer risk among women of African ancestry.

Babatunde Adedokun
Zhaohui Du
Dezheng Huo
ResearchOpen Access07 Jul 2021
Nature Communications

Volume: 12, P: 1-8
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells

Cancer cells that have undergone whole-genome doubling are more reliant than their near-diploid counterparts on DNA-replication factors, the spindle-assembly checkpoint and a mitotic kinesin protein, KIF18A.

Ryan J. Quinton
Amanda DiDomizio
Neil J. Ganem
Research27 Jan 2021
Nature

Volume: 590, P: 492-497
Identification of the kinase STK25 as an upstream activator of LATS signaling

Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range of human cancers.

Sanghee Lim
Nicole Hermance
Neil J. Ganem
ResearchOpen Access04 Apr 2019
Nature Communications

Volume: 10, P: 1-17
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

Adam Bass, Gad Getz and colleagues report whole-exome sequencing of 149 esophageal adenocarcinomas (EACs) and whole-genome sequencing of 15 EACs. They identify a mutational signature defined by a high prevalence of A>C transversions, as well as 26 genes mutated at high frequency in EACs.

Austin M Dulak
Petar Stojanov
Adam J Bass
Research24 Mar 2013
Nature Genetics

Volume: 45, P: 478-486
Carrier detection and prenatal diagnosis of hemophilia A in a Korean population by PCR-based analysis of the BclI/intron 18 and St14 VNTR polymorphisms

Y. M. Choi
D. Hwang
S. Cho
Research01 Jul 2000
Journal of Human Genetics

Volume: 45, P: 218-223
Matched unrelated bone marrow transplant for T+ combined immunodeficiency

C M Roifman
R Somech
E Grunebaum
Research11 Feb 2008
Bone Marrow Transplantation

Volume: 41, P: 947-952
Bone marrow transplantation for cartilage-hair-hypoplasia

R Guggenheim
R Somech
C M Roifman
Research16 Oct 2006
Bone Marrow Transplantation

Volume: 38, P: 751-756
Treatment Enhances Ultradian Rhythms of CSF Monoamine Metabolites in Patients with Major Depressive Episodes

Ronald M Salomon
John S Kennedy
Richard G Shiavi
Research27 Apr 2005
Neuropsychopharmacology

Volume: 30, P: 2082-2091
Lithium, but not Valproate, Reduces Impulsive Choice in the Delay-Discounting Task in Mice

Meredith E Halcomb
Todd D Gould
Nicholas J Grahame
Research12 Apr 2013
Neuropsychopharmacology

Volume: 38, P: 1937-1944
Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium

Jessica L. Petrick
Charlotte E. Joslin
Lynn Rosenberg
Research21 Oct 2023
British Journal of Cancer

Volume: 129, P: 1956-1967
The oral microbiome in relation to pancreatic cancer risk in African Americans

Jessica L. Petrick
Jeremy E. Wilkinson
Julie R. Palmer
Research30 Oct 2021
British Journal of Cancer

Volume: 126, P: 287-296
The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis

N M Anderson
D Li
H Feng
Research15 Feb 2016
Leukemia

Volume: 30, P: 1365-1374
Homozygous duplication identified by whole genome sequencing causes LRBA deficiency

Daniele Merico
Yehonatan Pasternak
Chaim M. Roifman
ResearchOpen Access18 Nov 2021
npj Genomic Medicine

Volume: 6, P: 1-6
Vpx-containing dendritic cell vaccine induces CTLs and reactivates latent HIV-1 in vitro

T D Norton
E A Miller
N R Landau
Research08 Jan 2015
Gene Therapy

Volume: 22, P: 227-236
Cancer health disparities in racial/ethnic minorities in the United States

Valentina A. Zavala
Paige M. Bracci
Laura Fejerman
ReviewsOpen Access09 Sept 2020
British Journal of Cancer

Volume: 124, P: 315-332

Search

Impact of midazolam vs. saline on effect size estimates in controlled trials of ketamine as a rapid-acting antidepressant

Active γ-carboxylated human factor IX expressed using recombinant DNA techniques

Mutational landscape of triple-negative breast cancer in African American women

ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome

Out-of-hospital births in California 1991–2011

Associations between social drivers of health and breast cancer stage at diagnosis among U.S. Black women

Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis

Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators

Effects of psychoplastogens on blood levels of brain-derived neurotrophic factor (BDNF) in humans: a systematic review and meta-analysis

PERIURETHRAL ANAEROBIC MICROFLORA IN UTI-PRONE AND HEALTHY GIRLS

DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

Targeting TBK1 to overcome resistance to cancer immunotherapy

Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality

Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women

Whole-genome doubling confers unique genetic vulnerabilities on tumour cells

Identification of the kinase STK25 as an upstream activator of LATS signaling

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

Carrier detection and prenatal diagnosis of hemophilia A in a Korean population by PCR-based analysis of the BclI/intron 18 and St14 VNTR polymorphisms

Matched unrelated bone marrow transplant for T+ combined immunodeficiency

Bone marrow transplantation for cartilage-hair-hypoplasia

Treatment Enhances Ultradian Rhythms of CSF Monoamine Metabolites in Patients with Major Depressive Episodes

Lithium, but not Valproate, Reduces Impulsive Choice in the Delay-Discounting Task in Mice

Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium

The oral microbiome in relation to pancreatic cancer risk in African Americans

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis

Homozygous duplication identified by whole genome sequencing causes LRBA deficiency

Vpx-containing dendritic cell vaccine induces CTLs and reactivates latent HIV-1 in vitro

Cancer health disparities in racial/ethnic minorities in the United States

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