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Altermagnets combine spin-split electronic bands with zero net magnetization, making them ideal for integration into spin-based information processing devices. Here Guo, Chen, Zeng, and coauthors demonstrate a magnetic memory making use of the altermagnetic spin splitting torque in a three terminal MRAM device.

Tong and colleagues reveal a cross-species conserved mechanism where locus coeruleus-norepinephrine mediated arousal fluctuations drive an inverted U-shaped pattern of global functional connectivity, uncovering a network basis of the Yerkes-Dodson law.

Codelivery of an antifungal drug within antifungal micelles achieves effective combinatorial therapy.

The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Poly(vinylidene fluoride-co-trifluoroethylene)’s (PVDF-TrFE) piezoelectricity can be enhanced by annealing, however current annealing methods are slow. Here, the authors perform ultra-fast flash annealing of PVDF-TrFE to achieve a high piezoelectricity.

The authors identify 92 tick-associated viruses, including ten pathogenic to humans in northwest China and adjacent countries. They predict a significant increase of major pathogenic viruses and their vectors in high-risk regions.

Ferromagnetic semiconductors that have the critical properties of semiconductors and ferromagnetism at room temperature have so far proven elusive. Here, by doping black phosphorus with Cobalt, Fu, Qu, Hou, Chang and coauthors induce ferromagnetism that persists up to room temperature, all while maintaining black phosphorus’ semiconducting properties.

Seasonal variation in K isotopes of rivers that drain the Chinese Loess Plateau indicates that riverine K isotopes can trace changes in silicate weathering intensity over time, offering a tool to track Earth’s climate–rock interactions.

Enantioselective introduction of two different carbon-based functional groups in a single step using readily accessible and inexpensive starting materials presents a significant challenge. Here the authors report an electrochemical copper-catalyzed protocol for the asymmetric cyanoesterification of vinylarenes using commercially available alkyl carbazates and trimethylsilyl cyanide (TMSCN) as the sources of ester and cyano groups, respectively.

Twisted two-dimensional materials are materials with fascinating properties. Here, the authors report on the incorporation of a crystallographically incompatible rotation element into two dimensional polymers to construct twist-stacked covalent organic framework nanofibers with interesting chiroptical properties.

TransBrain translates brain phenotypes between mouse and human via homology mapping, thus making it possible to capitalize on the wealth of knowledge about the mouse brain and gain insights into the human brain.

Water and sediments in artificial reservoirs face increasing pollution from polycyclic aromatic hydrocarbons, and effective management depends on considering distinct chemical and regional patterns, according to analysis of a global dataset.

The CorA-associated type III-B CRISPR–Cas system synthesizes S-adenosyl methionine (SAM)-AMP, triggering immune responses. Through structural characterization and biochemical validation, Duan and Jin et al. unveil unique mechanisms for SAM-AMP synthesis and degradation and provide insights into the molecular basis of type III CRISPR–Cas signaling.

Alternative splicing (AS) is a source of transcriptomic heterogeneity, but analysing splicing changes at single-cell level is challenging due to dropout, noise, and limited coverage in scRNA-seq. Here, the authors propose SCSES, a tool to identify AS events and estimate splicing intensity at single-cell resolution. SCSES reveals high splicing heterogeneity beyond conventional expression-based clustering.

Existing solutions based Advanced Encryption Standard to address the security issues of nonvolatile memories incurs significant performance and power overhead. Here, the authors propose a lightweight XOR-gate based encryption/decryption technique by exploiting in-situ array operations, which achieves significant area/latency/power reduction compared to conventional designs.

Xiao et al. uncover a strong linkage between marine bacterial tetraether lipids and benthic oxygen uptake in deepsea trench regions, indicating their potential for assessing microbial diagenetic activity and organic carbon degradation.

Zhuang, Zi et al. identify cyclin-dependent kinase 3 (CDK3) as a driver of neuron loss in Alzheimer’s disease that is associated with brain atrophy and memory decline in mice. Inhibition of CDK3 (BMX330) is shown to limit neuronal loss and improve cognition.

Sponge animals likely originated in the Precambrian, but their early spicular fossils are ambiguous. Here, Tang et al. report a new Cambrian sponge taxon with weakly biomineralized spicules and suggest that the poor Precambrian record may reflect the later evolution of biomineralization.

ESKAPE pathogens-induced meningitis threatens human health due to antimicrobial resistance and low permeability of blood-brain barrier (BBB). Here, the authors report that biguanide-functionalized poly(2-oxazoline) exhibits potent activity against drug-resistant ESKAPE pathogens and effectively penetrates the BBB, providing a promising strategy for combating ESKAPE pathogens and meningitis.

Weak transitions have a prominent role in optical clock devices and fundamental physics tests but are challenging to resolve due to the unfavourable scaling of the cross section with transition strengths. Here, the authors demonstrate enhanced cross sections due to beyond single-photon excitations in He atoms, facilitating applications in precision spectroscopy.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

High-voltage, anode-free sodium metal batteries combine high energy density and sustainability, but the lack of suitable electrolytes hinders their application. This work formulates an eco-friendly electrolyte design that supports exciting performance in such batteries.

Enantioenriched α-arylated dialkyl ketones with acidic proton are ubiquitous subunits in organic molecules and serve as synthetic precursors for other value-added chiral blocks. Here, the authors report a synthetic strategy of enantioenriched α-arylated dialkyl ketones enabled by nickel-catalyzed iterative cross-hydrocarbonylation of two alkenes.

Convergent selection between crops can help to identify genetic variants with important roles in adaptation as a source of diversity for the improvement of cultivated species through the concept of inter-crop translational research for breeding.

Immune evasion mechanisms of initial HIV infection are incompletely understood. Here, the authors show that HIV rewires the glycosylation machinery of infected myeloid cells, forming a glycan shield that engages glyco-immune checkpoints and inhibits cell function, and thus targeted killing of infected cells.

Growth signaling has been involved in the biological program of aging. Here the authors identify ARMH4 as a pro-aging factor by enhancing IGF1R/FGFR1 signal transduction and their expressions, thereby forming a positive feedback circuit in aging.

Prokaryotic pan-genome analysis is crucial for understanding microbial diversity, however current analytical methods often struggle to balance accuracy and computational efficiency. Here the authors present a more precise, robust and scalable toolkit for large-scale pan genome analysis.

Confocal Airy beam integrated with single-photon oblique light-sheet tomography (CAB-OLST) is a high-throughput imaging approach for brain-wide mapping of neurons, as demonstrated in cleared mouse brains.

Single atoms trapped in optical tweezers offer a promising route to quantum computing, but large-scale individual qubit control remains challenging. Here the authors propose and realize a fiber array architecture that enables independent and highly parallel control of single qubits in a neutral atom array.

Radiative cooling is an emerging technology for cooling with reduced energy consumption. Here the authors present photoluminescent composites that combine subambient cooling with aesthetic colour, hydrophobicity and durability.

Immiscibility limits the performance of positive mixing enthalpy alloys. Here, the authors apply ultrafast sintering and quenching to fabricate mechanically interlocked Cu-Fe composites with good strength and conductivity.

Reconstructing transcription–translation-coupled DNA replication (TTcDR) in artificial systems is crucial for creating synthetic life. Here the authors develop LoopReX, a TTcDR which leverages minimal machinery and artificial nucleoids to support multiple biological functions.

Selective catalytic reduction of NOx to N₂ using methanol as the reductant (Methanol-SCR) offers a promising route for eliminating NOx emissions from methanol engines and coal-fired power plants, but its performance at low temperatures remains limited. Here, the authors identify a strategy to enhance low-temperature Methanol-SCR activity through the cooperation between zeolitic acid sites and single iron redox sites.

CABLE harnesses cytoarchitectural information such as cell or nuclear shape to infer fiber tracts in the brain of, for example, marmosets, macaques or humans.

The first sample of farside lunar soil, collected by Chang’e-6, is strongly cohesive. The high cohesion stems from its fine particle size with intricate shape, probably a result of the high plagioclase abundance and intense meteorite impacts at the sampling site.

Reductive cross-coupling of aryl chlorides or electron-rich aryl bromides with benzyl chlorides remains a significant challenge, presumably due to the lower reactivity of aryl chlorides or electron-rich aryl bromides with the nickel catalyst compared with aryl iodides. Here, the authors present Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yielding chiral 1,1-diaryl compounds with good to excellent enantioselectivity, without resorting to heterogeneous metal reductants or sacrificial anodes.

Protecting healthy and stable wetlands is important for retaining biodiversity and ecosystem services. Using a nationwide wetland survey in the United States, the authors find that wetland productivity and stability are more strongly associated with community-level plant traits than with plant functional diversity.

Skeletal muscle is central to whole-body energy balance. Here, Yang et al. show that MLL4-dependent enhancer activation is a key regulatory node for the governance of muscle metabolic efficiency and systemic metabolism via the control of muscle AMPK.

Standard first line therapy in patients with non-small cell lung cancer is immunotherapy but responses vary and consistent predictive biomarkers are lacking. Here, using RNA-sequencing data from a large clinical trial in NSCLC patients, the authors define four molecular subsets with distinct tumour-intrinsic and -extrinsic features with differing outcomes to immunotherapy combinations.

The authors report a large-scale spin-locking effect of light within a Brownian medium arising from the intrinsic spin–orbit interactions of scattering from multiple individual nanoparticles in a complex disordered system.

Li-metal batteries suffer from sluggish kinetics at low temperatures. Here, authors propose a guideline for rational electrolyte solvent screening and design a class of asymmetric ethers, which bestows the Li metal pouch cell with a high specific energy of 345.3 Wh kg⁻¹ over 40 cycles at −40 °C.

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