Scott and colleagues show that expression of the transcription factor Sox9 is closely correlated with the transition from neuroepithelial cell to neural stem cell (NSC) during embryogenesis. Expression of Sox9 in early neuroepithelium elicited premature generation of NSCs. In the adult brain, Sox9 was necessary for the maintenance of NSCs and ependymal cells.
- Charlotte E Scott
- Sarah L Wynn
- James Briscoe