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Showing 1–5 of 5 results
Advanced filters: Author: Edahí González-Avalos Clear advanced filters

  • Chronic antigen stimulation leads to CD8+ T cell exhaustion, which is mediated by persistent activation of the transcription factor NFAT in the absence of AP-1. Seo, González-Avalos and colleagues show that overexpressed BATF cooperates with IRF4 to counteract NFAT-induced exhaustion and promote better tumor control by CAR T cells in mouse models.

    • Hyungseok Seo
    • Edahí González-Avalos
    • Patrick G. Hogan
    Research
    Nature Immunology
    Volume: 22, P: 983-995

  • TET proteins regulate 5-methylcytosine epigenetic marks, and thereby regulate chromatin accessibility. Rao and colleagues show that the combined loss of TET2 and TET3 in thymocytes skews development to iNKT17 cells as a result of upregulation of RORγt, which leads to lymphoproliferative disease and premature death.

    • Ageliki Tsagaratou
    • Edahí González-Avalos
    • Anjana Rao
    Research
    Nature Immunology
    Volume: 18, P: 45-53

  • It is debated how follicular helper T (Tfh) cells versus central memory CD4+ T cells arise from similar precursors, and little is known about the regulation of germinal-centre (GC)-Tfh cell differentiation. Here, authors establish markers in the early precursor stage that distinguish between the GC-Tfh and memory T cell fates and identify an important mechanism that regulates the competitive fitness of the GC-Tfh cells.

    • Fangming Zhu
    • Ryan J. McMonigle
    • Hui Hu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Shukla, Samaniego-Castruita and colleagues show that loss of TET methylcytosine dioxygenases in B cells is associated with increased DNA–RNA hybrids and G-quadruplex DNA structures in parallel with genomic instability and development of germinal center-derived lymphomas.

    • Vipul Shukla
    • Daniela Samaniego-Castruita
    • Anjana Rao
    Research
    Nature Immunology
    Volume: 23, P: 99-108

  • TET dioxygenases are known to have tumour suppressor activity. Here, An et al. show that Tet2/Tet3 double conditional mutant mice develop aggressive myeloid leukaemia, and suggest that rather than increased DNA methylation, aberrant gene expression and defects in DNA damage response and repair are the major drivers of myeloid leukaemogenesis upon TET loss-of-function.

    • Jungeun An
    • Edahí González-Avalos
    • Anjana Rao
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14