Nature Search

Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX

Mary Mac Partlin
Elizabeth Homer
Robert Brown
Research13 Feb 2003
Oncogene

Volume: 22, P: 819-825
FACS isolation of endothelial cells and pericytes from mouse brain microregions

This protocol describes how to isolate endothelial cells and pericytes from adult mouse brain microregions using fluorescence-activated cell sorting without requirement for transgenic mice. The cells may be used for diverse downstream applications.

Elizabeth E Crouch
Fiona Doetsch
Protocols22 Mar 2018
Nature Protocols

Volume: 13, P: 738-751
The molecular landscape of vascular cells in the human brain

A study using advanced single-cell technologies has broadened our understanding of the diversity and complexity of brain endothelial cells by uncovering new endothelial subtypes and transcriptional patterns. These findings offer insights into potential therapeutic targets and emphasize the need for further research on vascular lineages and neurovascular interactions.

Elizabeth E. Crouch
News & Views20 Sept 2024
Nature Reviews Cardiology

Volume: 21, P: 847-848
Erratum: The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Michael Kruhlak
Elizabeth E. Crouch
Rafael Casellas
Amendments and Corrections04 Jun 2009
Nature

Volume: 459, P: 736
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Chen et al. show that subtypes of immune cells in prenatal human brain promote angiogenesis in the germinal matrix. Conversely, in preterm infants, proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage.

Jiapei Chen
Elizabeth E. Crouch
Eric J. Huang
ResearchOpen Access30 Sept 2024
Nature Neuroscience

Volume: 27, P: 2115-2129
Profiling human brain vascular cells using single-cell transcriptomics and organoids

A protocol extension describing the purification of prenatal human brain endothelial and mural cells with FACS and their utilization in downstream applications, including cell culture, organoid transplantation and single-cell transcriptomics.

Elizabeth E. Crouch
Loukas N. Diafos
Eric J. Huang
Protocols15 Dec 2023
Nature Protocols

Volume: 19, P: 603-628
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer

There is high prevalence of whole genome duplication (WGD) in high grade serous ovarian cancer. Here, the authors compare tumours with and without WGD and find that those that acquired WGD early during tumour evolution are associated with worse survival and have the lowest expression of MHC-II.

Nikki L. Burdett
Madelynne O. Willis
Elizabeth L. Christie
ResearchOpen Access18 Jul 2024
Nature Communications

Volume: 15, P: 1-13
EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

The EWS–FLI1 fusion protein, expressed in Ewing sarcoma, increases global transcription, causes accumulation of R loops and replication stress, and impairs BRCA1-mediated repair.

Aparna Gorthi
July Carolina Romero
Alexander J. R. Bishop
Research07 Mar 2018
Nature

Volume: 555, P: 387-391
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

DNA damage leads to transient repression of ribosomal gene transcription by RNA polymerase I in a pathway mediated by ATM kinase activity and the DNA repair factors Nbs1 and MDC1

Michael Kruhlak
Elizabeth E. Crouch
Rafael Casellas
Research07 Jun 2007
Nature

Volume: 447, P: 730-734
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease.

Sonja I. Berndt
Nicola J. Camp
Susan L. Slager
ResearchOpen Access09 Mar 2016
Nature Communications

Volume: 7, P: 1-9
Individual human cortical progenitors can produce excitatory and inhibitory neurons

Molecular barcoding is used to show that progenitor cells in the human cortex can produce both excitatory neurons and inhibitory interneurons, with implications for our understanding of the evolution of the human brain.

Ryan N. Delgado
Denise E. Allen
Tomasz J. Nowakowski
Research15 Dec 2021
Nature

Volume: 601, P: 397-403
The nucleolus at Salmanca

E. G. Jordan
U. E. Loening
News & Views29 Sept 1977
Nature

Volume: 269, P: 376-377
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Susan Slager and colleagues report a meta-analysis of genome-wide association studies for chronic lymphocytic leukemia (CLL). They identify nine loci newly associated with CLL.

Sonja I Berndt
Christine F Skibola
Susan L Slager
Research16 Jun 2013
Nature Genetics

Volume: 45, P: 868-876
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resistance in HGSOC.

Olga Kondrashova
Monique Topp
Clare L. Scott
ResearchOpen Access28 Sept 2018
Nature Communications

Volume: 9, P: 1-16
Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Genome-wide association studies have identified regions which confer risk of high-grade serous epithelial ovarian cancer. Here the authors use expression quantitative train locus analysis to identify candidate genes and functionally characterise them, identifying a role for HOXD9 in ovarian cancer.

Kate Lawrenson
Qiyuan Li
Matthew L. Freedman
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-14
Developmental dynamics of RNA translation in the human brain

Duffy et al. profiled mRNA translation in 73 human prenatal and adult cortex samples and identified thousands of previously unknown translation events, including small open reading frames that give rise to human-specific and/or brain-specific microproteins.

Erin E. Duffy
Benjamin Finander
Michael E. Greenberg
Research28 Sept 2022
Nature Neuroscience

Volume: 25, P: 1353-1365
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Kathy Sivils and colleagues report results of a large-scale association study of Sjögren's syndrome, a common autoimmune disease. They confirm strong associations with the HLA region and establish genome-wide significant associations at several non-HLA loci implicated in both innate and adaptive immunity.

Christopher J Lessard
He Li
Kathy L Sivils
Research06 Oct 2013
Nature Genetics

Volume: 45, P: 1284-1292
Comparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesicle component

Dylan Sheerin
Daniel O’Connor
Andrew J. Pollard
ResearchOpen Access24 Sept 2019
Scientific Reports

Volume: 9, P: 1-14
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

James Cerhan and colleagues report genome-wide association and meta-analysis studies to identify genetic susceptibility loci for diffuse large B cell lymphoma. They identify four loci that influence genetic susceptibility to this B cell malignancy.

James R Cerhan
Sonja I Berndt
Stephen J Chanock
Research28 Sept 2014
Nature Genetics

Volume: 46, P: 1233-1238
Circulating CD34⁺ cell subsets in patients with coronary endothelial dysfunction

Endothelial dysfunction is an early manifestation of atherosclerotic disease. Circulating cells that express CD34, including endothelial and hematopoietic progenitor cells, might play a part in the development and progression of atherosclerosis. In this paper the authors evaluate the association between coronary endothelial dysfunction and concentrations of circulating CD34⁺cell subsets.

Barry A Boilson
Thomas J Kiernan
Robert D Simari
Research24 Jun 2008
Nature Clinical Practice Cardiovascular Medicine

Volume: 5, P: 489-496
Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

Nikki L. Burdett
Madelynne O. Willis
Elizabeth L. Christie
ResearchOpen Access11 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
Parkinson’s families project: a UK-wide study of early onset and familial Parkinson’s disease

Clodagh Towns
Zih-Hua Fang
Raquel Real
ResearchOpen Access17 Oct 2024
npj Parkinson's Disease

Volume: 10, P: 1-13
Should neonatal-perinatal medicine move to two-year fellowships?

Shetal Shah
Patrick Myers
Satyan Lakshminrusimha
Reviews08 Jun 2024
Journal of Perinatology

Volume: 44, P: 1222-1227
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang
Dane Cheasley
Kylie L. Gorringe
Research28 Jul 2020
Modern Pathology

Volume: 34, P: 194-206
Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao
Amanda Russell
Anna deFazio
ResearchOpen Access09 May 2014
Scientific Reports

Volume: 4, P: 1-9

Search

Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX

FACS isolation of endothelial cells and pericytes from mouse brain microregions

The molecular landscape of vascular cells in the human brain

Erratum: The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Profiling human brain vascular cells using single-cell transcriptomics and organoids

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer

EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Individual human cortical progenitors can produce excitatory and inhibitory neurons

The nucleolus at Salmanca

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Developmental dynamics of RNA translation in the human brain

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Comparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesicle component

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Circulating CD34⁺ cell subsets in patients with coronary endothelial dysfunction

Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

Parkinson’s families project: a UK-wide study of early onset and familial Parkinson’s disease

Should neonatal-perinatal medicine move to two-year fellowships?

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

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