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Showing 1–4 of 4 results
Advanced filters: Author: Emeline Ragonnaud Clear advanced filters

  • Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.

    • Monica Bodogai
    • Bongsoo Park
    • Arya Biragyn
    Research
    Nature Aging
    Volume: 5, P: 2055-2069

  • Alzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behavioural manifestations of the disease.

    • Ki Kim
    • Xin Wang
    • Arya Biragyn
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The tumour microenvironment has been shown to change the phenotypes and functionality of immune cells to enable tumour propagation. Here authors show that cancers can derail B cell development to give rise to macrophage-like cells, contributing to cancer progression and metastasis via disabling local T cell response.

    • Chen Chen
    • Bongsoo Park
    • Arya Biragyn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Caloric restriction (CR) has been shown as an effective intervention to reduce tumorigenesis, but alternative less stringent dietary interventions have also been considered. Here, the authors show that in a murine model of breast cancer CR has a larger effect on preventing tumorigenesis and metastasis compared to periodic caloric cycling.

    • Laura C. D. Pomatto-Watson
    • Monica Bodogai
    • Rafael de Cabo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17