Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 101–150 of 410 results
Advanced filters: Author: Emily Au Clear advanced filters
  • Autoantibodies are found in neuropsychiatric conditions but without clear cellular mechanism and disease relevance. This study shows higher prevalence of autoantibodies against NMDAR receptors in schizophrenia patients, and patient-associated antibody can alter synaptic receptor trafficking and plasticity.

    • Julie Jézéquel
    • Emily M. Johansson
    • Laurent Groc
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15
  • Increasing evidence suggests that antigen presentation by B cells is critical to the initiation of autoimmunity. Here, the authors demonstrate that tolerance breakdown is initiated outside of germinal centres and that B cells can directly instruct T cells to break tolerance and propagate autoimmune responses.

    • Cecilia Fahlquist-Hagert
    • Thomas R. Wittenborn
    • Søren E. Degn
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21
  • A variant of MHC class I is protective against severe malaria disease and enriched in affected African populations. Here, Wroblewski et al., characterise the consequences of malaria infection in wild bonobo populations showing that the presence of malaria drives a similar evolution in immune genes.

    • Emily E. Wroblewski
    • Lisbeth A. Guethlein
    • Peter Parham
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11
  • Complementary types of retinal ganglion cell form mosaics with receptive fields that are farther apart than would be expected by chance, supporting the efficient coding of natural scenes.

    • Suva Roy
    • Na Young Jun
    • Greg D. Field
    Research
    Nature
    Volume: 592, P: 409-413
  • Cryo-electron microscopy and single-molecule fluorescence methods are used to elucidate the mechanism of early translocation events on the bacterial ribosome.

    • Emily J. Rundlet
    • Mikael Holm
    • Scott C. Blanchard
    ResearchOpen Access
    Nature
    Volume: 595, P: 741-745
  • The mechanics of the migration of T cells into tumours is an important aspect of tumour immunity. Here the authors engineer complex 3D environments to explore functions of microtubules and cell contractility as strategies to enhance T cell migration in tumour microenvironments.

    • Erdem D. Tabdanov
    • Nelson J. Rodríguez-Merced
    • Paolo P. Provenzano
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17
  • Understanding the effect of vaccination on emerging SARS-CoV-2 variants of concern is of increasing importance. Here, James et al. report that two doses of vaccination with the Pfizer-BioNTech vaccine induce more robust immune responses to the B.1.1.7 and B.1.351 SARS-CoV-2 lineages than does natural infection.

    • Donal T. Skelly
    • Adam C. Harding
    • William S. James
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12
  • Intravital imaging reveals macrophage-driven de novo induction of cancer stem cells in vivo, and their dramatic enrichment on dissemination through TMEM doorways. These findings provide a mechanism for the validated ability of TMEM doorway density to be prognostic for distant recurrence of metastatic tumors in breast cancer patients.

    • Ved P. Sharma
    • Binwu Tang
    • Maja H. Oktay
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-24
  • People living in Bangladesh’s coastal zone face multiple water-related risks. This modelling study finds that rising salinity and waterlogging negate the benefits of rehabilitating embankments for reducing crop loss, with impacts being greatest for the poor. Drainage was found to reduce negative impacts.

    • Emily J. Barbour
    • Mohammed Sarfaraz Gani Adnan
    • Jim W. Hall
    Research
    Nature Sustainability
    Volume: 5, P: 294-302
  • This study presents the genomes of 2,101 emm28 Streptococcus pyogenes invasive strains, of which 492 were transcriptionally profiled, and 50 were assessed for virulence. GWAS, eQTL analysis, and study of isogenic mutant strains identified an intergenic region that alters global transcript profiles and bacterial virulence.

    • Priyanka Kachroo
    • Jesus M. Eraso
    • James M. Musser
    Research
    Nature Genetics
    Volume: 51, P: 548-559
  • Cellular senescence involves extensive structural changes to chromatin, but the role of histone variants and histone cleavage is unknown. Here, Duarte et al.identify histone variant H3.3 and its proteolytically processed form lacking a portion of the N-terminal tail as key regulators of senescence.

    • Luis F. Duarte
    • Andrew R. J. Young
    • Emily Bernstein
    Research
    Nature Communications
    Volume: 5, P: 1-12
  • In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

    • Aurélie Wiedemann
    • Edouard Lhomme
    • Huanying Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • Here the authors report that enhancers appear more often in late-replicating DNA regions and are enriched for mutations affecting TF binding. This relationship with DNA replication time is seen in species evolution and cancer, suggesting a fundamental principle of genome evolution.

    • Paola Cornejo-Páramo
    • Veronika Petrova
    • Emily S. Wong
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

    • Bin Zhou
    • Kate E. Sheffer
    • Majid Ezzati
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 2885-2901
  • Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic reprogramming.

    • Emily Golden
    • Rabab Rashwan
    • Pilar Blancafort
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22
  • The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations.

    • Aldo Scarpa
    • David K. Chang
    • Sean M. Grimmond
    Research
    Nature
    Volume: 543, P: 65-71
  • Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

    • Andrew V. Biankin
    • Nicola Waddell
    • Sean M. Grimmond
    Research
    Nature
    Volume: 491, P: 399-405
  • Fendt and colleagues find that pre-metastatic niche formation and a high-fat diet increase palmitate availability in future organs of metastases and show that breast cancer cells use palmitate to generate acetyl-CoA, acetylate the NF-κB subunit p65 and induce pro-metastatic signaling.

    • Patricia Altea-Manzano
    • Ginevra Doglioni
    • Sarah-Maria Fendt
    Research
    Nature Cancer
    Volume: 4, P: 344-364
  • Sweet taste plays a key role in promoting ingestion of nutritionally rich sources of carbohydrates. Here, the authors demonstrate that the pharyngeal sense organs in adult Drosophilaare important for directing the sustained consumption of sweet compounds.

    • Emily E. LeDue
    • Yu-Chieh Chen
    • Michael D. Gordon
    Research
    Nature Communications
    Volume: 6, P: 1-8
  • Linterman and colleagues examine germinal center formation in older individuals. They find that aged TFH cells have dysregulated CXCR4 expression, which causes spatial mislocalization of these cells in germinal centers, impairing their ability to provide help to B cells and to promote antibody production.

    • Alyssa Silva-Cayetano
    • Sigrid Fra-Bido
    • Michelle A. Linterman
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 1124-1137
  • Osteoarthritis (OA) is an important cause of disability worldwide, and its impact is growing rapidly. In this Opinion article, the authors draw attention to the current and projected burden of OA for individuals and for health-care systems, and call for a shift in the approach to the disease.

    • David J. Hunter
    • Deborah Schofield
    • Emily Callander
    Comments & Opinion
    Nature Reviews Rheumatology
    Volume: 10, P: 437-441
  • A clinical decision support system for diagnosis of myocardial infarction, based on machine learning models that use a single measurement of high-sensitivity troponin, outperforms clinical guidelines that use fixed cardiac troponin thresholds for diagnosis.

    • Dimitrios Doudesis
    • Kuan Ken Lee
    • Stephen W. Smith
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1201-1210
  • LSD1 inhibition blocks the neuroendocrine phenotype of some small cell lung cancers (SCLCs). Here, a genome-wide CRISPR/Cas9 LSD1 inhibitor resistance screen identifies the mRNA-binding protein ZFP36L1 as a gene repressed by LSD1 that when restored inhibits SCLC neuroendocrine differentiation.

    • Hsiao-Yun Chen
    • Yavuz T. Durmaz
    • Matthew G. Oser
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-22
  • The engagement of immunological memory is a key component to the protective anti-SARS-CoV-2 B and T cell responses. Here the authors assess the B and T cells of a cohort of UK healthcare workers in response to infection and longitudinally track the compartment showing distinct trajectories following early priming.

    • Adriana Tomic
    • Donal T. Skelly
    • Susanna J. Dunachie
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20
  • There is increasing evidence of a functional interaction between acute myeloid leukemia (AML) and immune cells, influencing disease outcome. Here the authors study how distinct oncogenes differentially affect the host immune response to leukemic cells in preclinical models of AML.

    • Rebecca J. Austin
    • Jasmin Straube
    • Megan J. Bywater
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • Patients with the Long QT Syndrome type 2 have abnormal cardiac electrical activity, which is diagnosed by an electrocardiogram (ECG) that shows a prolonged QT interval and a notched T wave. Here the authors uncover the origins of this signature ECG phenotype by using a multi-scale cardiac modelling.

    • Arash Sadrieh
    • Luke Domanski
    • Adam P Hill
    Research
    Nature Communications
    Volume: 5, P: 1-11
  • Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely related protective and less protective HLA alleles, and their differential effect on viral control

    • Funsho Ogunshola
    • Gursev Anmole
    • Zaza M Ndhlovu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14
  • Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the roles of FOS and SCG2 in neural plasticity and consolidation of memories.

    • Ee-Lynn Yap
    • Noah L. Pettit
    • Michael E. Greenberg
    Research
    Nature
    Volume: 590, P: 115-121
  • Mitophagy is an important quality control pathway. Here, the authors identify the mechanisms enabling the TBK1 adaptors NAP1 and SINTBAD to prevent hyperactivation of PINK1/Parkin mitophagy while promoting the pathway once set in motion.

    • Elias Adriaenssens
    • Thanh Ngoc Nguyen
    • Sascha Martens
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1717-1731
  • mRNA vaccines must be rigorously analysed to measure their integrity and detect contaminants, which can be time-consuming and costly. Here, authors describe a method to analyse mRNA vaccine quality using long-read sequencing and a custom bioinformatic pipeline.

    • Helen M. Gunter
    • Senel Idrisoglu
    • Tim R. Mercer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12
  • Giovannoni et al. report that the aryl hydrocarbon receptor (AHR) is a novel host factor exploited by Zika virus and dengue virus to evade the immune response. AHR is a candidate target for the treatment of Zika virus congenital syndrome and dengue fever.

    • Federico Giovannoni
    • Irene Bosch
    • Francisco J. Quintana
    Research
    Nature Neuroscience
    Volume: 23, P: 939-951
  • Transmission spectroscopy observations from the James Webb Space Telescope show the detection of carbon dioxide in the atmosphere of the gas giant exoplanet WASP-39b.

    • Eva-Maria Ahrer
    • Lili Alderson
    • Sebastian Zieba
    ResearchOpen Access
    Nature
    Volume: 614, P: 649-652
  • CTLA-4 is critical for balancing protective immunity with self-tolerance. Here the authors identify homozygous DEF6 mutations in patients with severe autoimmunity, one of which received and responds to CTLA-4-Ig, and show that DEF6 is crucial for CTLA-4 cell surface trafficking and immune regulatory function.

    • Nina K. Serwas
    • Birgit Hoeger
    • Kaan Boztug
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15
  • Here, the authors provide mechanistic insights into how decitabine-induced DNA hypomethylation can potentially overcome endocrine resistance in ER+ breast cancer, by targeting the 3D epigenome to resolve gene deregulation and suppress tumor growth.

    • Joanna Achinger-Kawecka
    • Clare Stirzaker
    • Susan J. Clark
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 498-512
  • Otopetrins are proton channels and candidate sour taste receptors. Cryo-EM structures of zebrafish Otop1 and chicken Otop3 reveal potential proton conduction pathways.

    • Kei Saotome
    • Bochuan Teng
    • Andrew B. Ward
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 518-525
  • Several human coronaviruses (CoV) have been proposed to emerge from bats but evidence of direct bat-to-human transmission is slim. In this work, the authors isolate a MERS-related CoV strain directly from bats and show that it infects target cells in vitro and engineered mice through the human DDP4 receptor.

    • Susanna K. P. Lau
    • Rachel Y. Y. Fan
    • Patrick C. Y. Woo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10
  • Increased effectiveness of anti-cancer chimeric antigen receptor T cell therapy is associated with a stem-like phenotype through increased expression of FOXO1.

    • Jack D. Chan
    • Christina M. Scheffler
    • Phillip K. Darcy
    ResearchOpen Access
    Nature
    Volume: 629, P: 201-210
  • Mangrove forests protect communities from storms and support fisheries. Here, the authors show that the association with economic growth has shifted from negatively impacting mangroves to enabling mangrove expansion, and that community forestry is promoting mangrove expansion.

    • Valerie Hagger
    • Thomas A. Worthington
    • Megan I. Saunders
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16