Nature Search

Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis

The authors provide a comprehensive characterization of how glutamine uptake and utilization regulate macrophage function in atherosclerosis.

Saloua Benhmammouch
Coraline Borowczyk
Laurent Yvan-Charvet
Research22 Sept 2025
Nature Metabolism

Volume: 7, P: 1924-1938
GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls

Murcy et al. show that increasing the plasma glutamine-to-glutamate ratio in atherosclerosis can distally reprogram transcriptional and post-transcriptional remodeling of the aorta by GLS2-dependent hepatic glutaminolysis.

Florent Murcy
Coraline Borowczyk
Laurent Yvan-Charvet
Research19 Nov 2024
Nature Cardiovascular Research

Volume: 3, P: 1454-1467
Variation in FTO contributes to childhood obesity and severe adult obesity

Christian Dina
David Meyre
Philippe Froguel
Research13 May 2007
Nature Genetics

Volume: 39, P: 724-726
A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

Jörg Hager
Christian Dina
Philippe Froguel
Research01 Nov 1998
Nature Genetics

Volume: 20, P: 304-308
Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function

Opioid use impacts metabolic homeostasis, although the mechanisms remain elusive. Here, the authors explore the OPRD1 gene (encoding the delta opioid receptor, DOP) to understand its impact on type 2 diabetes and highlight DOP as a key player between opioids and metabolic homeostasis.

Sarah Meulebrouck
Judith Merrheim
Amélie Bonnefond
ResearchOpen Access05 Aug 2024
Nature Communications

Volume: 15, P: 1-12
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

Merlin et al. find that non-canonical glutamine transamination is required for macrophage efferocytosis in atherosclerotic plaques by sustaining redox buffering and fueling energy production for cytoskeletal rearrangements.

Johanna Merlin
Stoyan Ivanov
Laurent Yvan-Charvet
Research14 Oct 2021
Nature Metabolism

Volume: 3, P: 1313-1326
Pathogenic variants in actionable MODY genes are associated with type 2 diabetes

Using data from 74,629 individuals from 4 independent surveys, Bonnefond et al. report a much stronger burden of pathogenic genetic variants of MODY genes among people diagnosed with type 2 diabetes than has previously been reported.

Amélie Bonnefond
Mathilde Boissel
Philippe Froguel
Research12 Oct 2020
Nature Metabolism

Volume: 2, P: 1126-1134
PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans

Catherine André, Judith Fischer and colleagues report that mutations in PNPLA1 cause congenital ichthyosis in humans and golden retriever dogs. Their findings suggest a role for PNPLA1 in the formation of the epidermal lipid barrier.

Anaïs Grall
Eric Guaguère
Judith Fischer
Research15 Jan 2012
Nature Genetics

Volume: 44, P: 140-147
Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

Large-scale sequencing of coding exons of MRAP2 in 9,418 adults and adolescents identifies loss-of-function mutations that are associated with monogenic obesity, hypertension and hyperglycemia.

Morgane Baron
Julie Maillet
Amélie Bonnefond
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1733-1738
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

Philippe Froguel, Ralf Jockers and colleagues report the functional characterization of 40 rare protein-coding variants of the MTNR1B gene (encoding melatonin receptor 1B, also known as MT₂). They find that functionally impaired MT₂ melatonin receptors confer higher risk to type 2 diabetes in Europeans.

Amélie Bonnefond
Nathalie Clément
Philippe Froguel
Research29 Jan 2012
Nature Genetics

Volume: 44, P: 297-301
Low copy number of the salivary amylase gene predisposes to obesity

Mario Falchi, Philippe Froguel and colleagues report association of a multi-allelic copy number variant encompassing the salivary amylase gene AMY1 with body mass index and risk of obesity.

Mario Falchi
Julia Sarah El-Sayed Moustafa
Philippe Froguel
Research30 Mar 2014
Nature Genetics

Volume: 46, P: 492-497
Loss-of-function mutations in ADCY3 cause monogenic severe obesity

Genetic analysis of children with severe obesity identifies mutations in the ADCY3 gene (encoding adenylate cyclase 3). These variants are rare in public databases and affect the functional activity of the protein, indicating that ADCY3 is a potential pharmacological target for obesity treatment.

Sadia Saeed
Amélie Bonnefond
Philippe Froguel
Research08 Jan 2018
Nature Genetics

Volume: 50, P: 175-179
Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models

Aurélie Rondon
Nancy Ty
Françoise Degoul
ResearchOpen Access02 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Evolution of the prevalence of obesity in the adult population in France, 2013–2016: the Constances study

Sébastien Czernichow
Adeline Renuy
Joane Matta
ResearchOpen Access08 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study

T Aparicio
M Svrcek
P Laurent-Puig
ResearchOpen Access05 Nov 2013
British Journal of Cancer

Volume: 109, P: 3057-3066

Search

Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis

GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls

Variation in FTO contributes to childhood obesity and severe adult obesity

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function

Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

Pathogenic variants in actionable MODY genes are associated with type 2 diabetes

PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

Low copy number of the salivary amylase gene predisposes to obesity

Loss-of-function mutations in ADCY3 cause monogenic severe obesity

Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models

Evolution of the prevalence of obesity in the adult population in France, 2013–2016: the Constances study

Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study

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